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Prelude Therapeutics Inc

PRLD

0.985USD

-0.025-2.50%
Close 09/19, 16:00ETQuotes delayed by 15 min
55.73MMarket Cap
LossP/E TTM

Prelude Therapeutics Inc

0.985

-0.025-2.50%

TradingKey Stock Score

Overall Financial Health

Valuation Dimensions

Earnings Forecast

Price Momentum

Institutional Confidence

Risk Assessment

Peer Comparison

TradingKey Stock Score

Overall Financial Health

Valuation Dimensions

Earnings Forecast

Price Momentum

Institutional Confidence

Risk Assessment

Peer Comparison

TradingKey Stock Score

Currency: USD Updated: 2025-09-19

Key Insights

The company's fundamentals are relatively stable. Its valuation is considered fairly valued,and institutional recognition is very high. Over the past 30 days, multiple analysts have rated the company as a Buy. Despite a good stock market performance, the company shows weak fundamentals and technicals, which don't support the current trend. The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Industry Ranking
170 / 506
Overall Ranking
281 / 4720
Industry
Biotechnology & Medical Research

Support & Resistance

No Data

Score Analysis

Current score
Previous score

Analyst Rating

Based on 4 analysts
Buy
Current Rating
3.500
Target Price
+246.53%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Company Highlights

StrengthsRisks
Prelude Therapeutics Incorporated is a clinical-stage fully integrated oncology company built on a foundation of drug discovery to deliver novel precision cancer medicines to underserved patients. It has developed a diverse pipeline consisting of multiple distinct programs: kinases, targeted protein degraders, and precision antibody drug conjugates. Its product candidates include PRT3789, PRT2527 and PRT3645. PRT3789 is a highly selective degrader of SMARCA2 protein, which along with SMARCA4, controls gene regulation through chromatin remodeling. Its CDK9 program is an essential regulator of cancer-promoting transcriptional programs, including those driven by MCL1, MYC and MYB. PRT3645 is a brain and tissue penetrant molecule that potently targets CDK4/6 with a biased selectivity for CDK4. PRT2527 is designed to be a potent and selective CDK9 inhibitor. Its MCL1 candidate, PRT1419, is designed to be a potent and selective inhibitor of the anti-apoptotic protein, MCL1.
Growing
The company is in a growing phase, with the latest annual income totaling USD 7.00M.
Overvalued
The company’s latest PE is -0.60, at a high 3-year percentile range.
Institutional Selling
The latest institutional holdings are 35.20M shares, decreasing 27.95% quarter-over-quarter.
Held by The Vanguard
Star Investor The Vanguard holds 932.57K shares of this stock.

Financial Health

Currency: USD Updated: 2025-09-19

The company's current financial score is 5.86, which is lower than the Biotechnology & Medical Research industry's average of 6.93. Its financial status is weak, and its operating efficiency is low.

Score

Industry at a Glance

Previous score
5.86
Change
0

Financials

5.64

Key Metrics

Cash and cash equivalents

Total assets

Total liabilities

Free cash flow

No Data

Quality of Earnings

7.39

Operational Efficiency

2.80

Growth Potential

6.39

Shareholder Returns

7.07

Company Valuation

Currency: USD Updated: 2025-09-19

The company’s current valuation score is 2.80, which is lower than the Biotechnology & Medical Research industry's average of 3.06. Its current P/E ratio is -0.62, which is 34.64% below the recent high of -0.83 and -262.70% above the recent low of -2.24.

Score

Industry at a Glance

Previous score
2.80
Change
0

Valuation Dimensions

P/E

P/B

P/S

P/CF

Industry Ranking 170/506
No Data

Earnings Forecast

Currency: USD Updated: 2025-09-19

The company’s current earnings forecast score is 7.50, which is lower than the Biotechnology & Medical Research industry's average of 8.03. The average price target for Prelude Therapeutics Inc is 4.00, with a high of 5.00 and a low of 1.00.

Score

Industry at a Glance

Previous score
7.50
Change
0

Support & Resistance

No Data

Analyst Rating

Based on 4 analysts
Buy
Current Rating
3.500
Target Price
+246.53%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

554
Total
5
Median
6
Average
Company name
Ratings
Analysts
Prelude Therapeutics Inc
PRLD
4
CRISPR Therapeutics AG
CRSP
30
Intellia Therapeutics Inc
NTLA
26
Exact Sciences Corp
EXAS
26
Ionis Pharmaceuticals Inc
IONS
26
IQVIA Holdings Inc
IQV
25
1
2
3
...
111

Financial Forecasting

EPS

Revenue

Net Profit

EBIT

No Data

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2025-09-19

The company’s current price momentum score is 4.58, which is lower than the Biotechnology & Medical Research industry's average of 6.58. Sideways: Currently, the stock price is trading between the resistance level at 1.22 and the support level at 0.90, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
4.58
Change
0.13

Support & Resistance

No Data

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(2)
Neutral(2)
Buy(0)
Indicators
Value
Direction
MACD(12,26,9)
-0.072
Neutral
RSI(14)
42.284
Neutral
STOCH(KDJ)(9,3,3)
6.084
Oversold
ATR(14)
0.105
Low Volatility
CCI(14)
-184.593
Sell
Williams %R
98.532
Oversold
TRIX(12,20)
0.471
Sell
StochRSI(14)
0.000
Oversold
Moving Average
Sell(4)
Neutral(0)
Buy(2)
Indicators
Value
Direction
MA5
1.061
Sell
MA10
1.127
Sell
MA20
1.176
Sell
MA50
0.992
Sell
MA100
0.946
Buy
MA200
0.935
Buy

Institutional Confidence

Currency: USD Updated: 2025-09-19

The company’s current institutional recognition score is 7.00, which is higher than the Biotechnology & Medical Research industry's average of 5.96. The latest institutional shareholding proportion is 80.72%, representing a quarter-over-quarter decrease of 0.59%. The largest institutional shareholder is The Vanguard, holding a total of 932.57K shares, representing 2.13% of shares outstanding, with 10.76% decrease in holdings.

Score

Industry at a Glance

Previous score
7.00
Change
0

Institutional Shareholding

No Data

Shareholder Activity

Name
Shares Held
Chg %
OrbiMed Advisors, LLC
10.91M
--
Baker Bros. Advisors LP
10.12M
-0.05%
Vaddi (Krishna)
3.67M
+29.33%
The Vanguard Group, Inc.
Star Investors
1.01M
-0.12%
T. Rowe Price Associates, Inc.
Star Investors
959.30K
-5.24%
Renaissance Technologies LLC
Star Investors
656.70K
+3.50%
Acadian Asset Management LLC
529.33K
+9.05%
Friedman (Paul A)
500.10K
--
Combs (Andrew P)
480.12K
+27.99%
Two Sigma Investments, LP
444.07K
-16.50%
1
2

Risk Assessment

Currency: USD Updated: 2025-09-19

The company’s current risk assessment score is 3.09, which is lower than the Biotechnology & Medical Research industry's average of 3.33. The company's beta value is 1.23. This indicates that the stock tends to outperform the index during upward trending markets but experiences larger declines during downward trending markets.

Score

Industry at a Glance

Previous score
3.09
Change
0
Beta vs S&P 500 index
1.22
VaR
+8.66%
240-Day Maximum Drawdown
+70.07%
240-Day Volatility
+116.80%
Return
Best Daily Return
60 days
+17.55%
120 days
+17.55%
5 years
+46.40%
Worst Daily Return
60 days
-10.34%
120 days
-10.34%
5 years
-42.65%
Sharpe Ratio
60 days
+1.31
120 days
+1.45
5 years
-0.37
Risk Assessment
Maximum Drawdown
240 days
+70.07%
3 years
+92.82%
5 years
+99.33%
Return-to-Drawdown Ratio
240 days
-0.72
3 years
-0.30
5 years
-0.20
Skewness
240 days
+1.86
3 years
+0.78
5 years
+0.47
Volatility
Realised Volatility
240 days
+116.80%
5 years
+103.92%
Standardised True Range
240 days
+10.23%
5 years
+105.64%
Downside Risk-Adjusted Return
120 days
+310.66%
240 days
+310.66%
Maximum Daily Upside Volatility
60 days
+68.20%
Maximum Daily Downside Volatility
60 days
+61.11%
Liquidity
Average Turnover Rate
60 days
+0.33%
120 days
+0.33%
5 years
--
Turnover Deviation
20 days
-5.52%
60 days
-13.39%
120 days
-12.59%

Peer Comparison

Biotechnology & Medical Research
Prelude Therapeutics Inc
Prelude Therapeutics Inc
PRLD
5.34 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Krystal Biotech Inc
Krystal Biotech Inc
KRYS
8.14 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
Alkermes Plc
ALKS
7.85 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
ACADIA Pharmaceuticals Inc
ACADIA Pharmaceuticals Inc
ACAD
7.67 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Zymeworks Inc
Zymeworks Inc
ZYME
7.64 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Veracyte Inc
Veracyte Inc
VCYT
7.59 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
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