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Denali Therapeutics Inc

DNLI
18.160USD
-1.575-7.98%
Close 03/27, 16:00ETQuotes delayed by 15 min
2.62BMarket Cap
LossP/E TTM

Denali Therapeutics Inc

18.160
-1.575-7.98%
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison

TradingKey Stock Score of Denali Therapeutics Inc

Currency: USD Updated: 2026-03-27

Key Insights

Denali Therapeutics Inc's fundamentals are relatively weak, with an industry-leading ESG disclosure.and its growth potential is high.Its valuation is considered fairly valued, ranking 70 out of 391 in the Biotechnology & Medical Research industry.Institutional ownership is very high.Over the past month, multiple analysts have rated it as Buy, with the highest price target at 33.29.In the medium term, the stock price is expected to trend up.Despite a weak stock market performance over the past month, the company shows strong technicals.The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Denali Therapeutics Inc's Score

Industry at a Glance

Industry Ranking
70 / 391
Overall Ranking
180 / 4542
Industry
Biotechnology & Medical Research

Support & Resistance

Relevant data have not been disclosed by the company yet.

Score Analysis

Current score
Previous score

Media Coverage

Last 24 hours
Coverage Level

Very Low
Very High
Neutral

Denali Therapeutics Inc Highlights

StrengthsRisks
Denali Therapeutics Inc. is a biopharmaceutical company. The Company is focused on developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for the treatment of neurodegenerative diseases and lysosomal storage diseases. It has developed a technology, called the TransportVehicle (TV), to address the BBB challenge. Its advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (MPS II or Hunter syndrome). Its TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for MPS IIIA (Sanfilippo syndrome) and DNL593 (PTV:PGRN) for frontotemporal dementia-granulin (FTD-GRN). Its small-molecule clinical development portfolio includes BIIB122/DNL151 (small molecule LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (small molecule eIF2B activator) for amyotrophic lateral sclerosis (ALS). It is also exploring programs in oncology, inflammation, and other diseases.
High Profit Growth
The company's net income leads the industry, with the latest annual income totaling USD 0.00.
Overvalued
The company’s latest PE is -6.12, at a high 3-year percentile range.
Institutional Buying
The latest institutional holdings are 148.33M shares, increasing 0.02% quarter-over-quarter.
Held by Invesco
Star Investor Invesco holds 210.25K shares of this stock.

Analyst Rating

Based on 19 analysts
Buy
Current Rating
33.286
Target Price
+58.73%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Financial Health

Currency: USD Updated: 2026-03-27

The current financial score of Denali Therapeutics Inc is 5.27, ranking 372 out of 391 in the Biotechnology & Medical Research industry. Its financial status is weak, and its operating efficiency is low.

Score

Industry at a Glance

Previous score
5.27
Change
0

Financials

2.04

Key Metrics

Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
Relevant data have not been disclosed by the company yet.

Quality of Earnings

7.57

Operational Efficiency

2.97

Growth Potential

6.75

Shareholder Returns

7.03

Denali Therapeutics Inc's Company Valuation

Currency: USD Updated: 2026-03-27

The current valuation score of Denali Therapeutics Inc is 6.48, ranking 266 out of 391 in the Biotechnology & Medical Research industry. Its current P/E ratio is -6.12, which is -29.66% below the recent high of -4.30 and -370.04% above the recent low of -28.75.

Score

Industry at a Glance

Previous score
6.48
Change
0

Valuation Dimensions

P/E
P/B
P/S
P/CF
Industry Ranking 70/391
Relevant data have not been disclosed by the company yet.

Earnings Forecast

Currency: USD Updated: 2026-03-27

The current earnings forecast score of Denali Therapeutics Inc is 8.84, ranking 50 out of 391 in the Biotechnology & Medical Research industry. The average price target is 32.00, with a high of 40.00 and a low of 24.00.

Score

Industry at a Glance

Previous score
8.84
Change
0

Support & Resistance

Relevant data have not been disclosed by the company yet.

Analyst Rating

Based on 19 analysts
Buy
Current Rating
33.286
Target Price
+58.73%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

548
Total
6
Median
6
Average
Company name
Ratings
Analysts
Denali Therapeutics Inc
DNLI
19
CRISPR Therapeutics AG
CRSP
29
IQVIA Holdings Inc
IQV
27
argenx SE
ARGX
26
Beigene Ltd
ONC
24
Intellia Therapeutics Inc
NTLA
24
1
2
3
...
110

Financial Forecasting

EPS
Revenue
Net Profit
EBIT
Relevant data have not been disclosed by the company yet.

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2026-03-27

The current price momentum score of Denali Therapeutics Inc is 6.45, ranking 220 out of 391 in the Biotechnology & Medical Research industry. Currently, the stock price is trading between the resistance level at 21.71 and the support level at 16.35, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
6.73
Change
-0.28

Support & Resistance

Relevant data have not been disclosed by the company yet.

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(3)
Neutral(2)
Buy(0)
Indicators
Value
Direction
MACD(12,26,9)
-0.377
Neutral
RSI(14)
38.836
Neutral
STOCH(KDJ)(9,3,3)
23.134
Sell
ATR(14)
1.284
High Vlolatility
CCI(14)
-229.729
Oversold
Williams %R
98.881
Oversold
TRIX(12,20)
0.014
Sell
StochRSI(14)
0.000
Sell
Moving Average
Sell(5)
Neutral(0)
Buy(1)
Indicators
Value
Direction
MA5
20.485
Sell
MA10
20.368
Sell
MA20
20.504
Sell
MA50
20.430
Sell
MA100
18.900
Sell
MA200
16.813
Buy

Institutional Confidence

Currency: USD Updated: 2026-03-27

The current institutional shareholding score of Denali Therapeutics Inc is 10.00, ranking 1 out of 391 in the Biotechnology & Medical Research industry. The latest institutional shareholding proportion is 104.72%, representing a quarter-over-quarter decrease of 1.28%. The largest institutional shareholder is The Vanguard, holding a total of 13.02M shares, representing 8.21% of shares outstanding, with 1.33% increase in holdings.

Score

Industry at a Glance

Previous score
10.00
Change
0

Institutional Shareholding

Relevant data have not been disclosed by the company yet.

Shareholder Activity

Name
Shares Held
Chg %
The Vanguard Group, Inc.
Star Investors
11.96M
+1.47%
Baillie Gifford & Co.
Star Investors
11.59M
-3.04%
BlackRock Institutional Trust Company, N.A.
10.13M
+2.61%
T. Rowe Price Investment Management, Inc.
5.64M
+73.66%
Biogen Inc
7.16M
-43.89%
Temasek Holdings Pte. Ltd.
5.36M
--
State Street Investment Management (US)
5.46M
+20.94%
Norges Bank Investment Management (NBIM)
3.95M
+270.44%
Fidelity Management & Research Company LLC
5.01M
-32.37%
T. Rowe Price Associates, Inc.
Star Investors
4.43M
-31.37%
1
2

Risk Assessment

Currency: USD Updated: 2026-03-27

The U.S. Dollar Index is currently in a neutral state, which has a neutral effect on the Biotechnology & Medical Research domestic-focused industry. The Dollar Index (DXY) measures the value of the U.S. dollar against a basket of major currencies, including the euro, yen, pound sterling, Canadian dollar, Swedish krona, and Swiss franc. The current risk assessment score of Denali Therapeutics Inc is 5.43, ranking 46 out of 391 in the Biotechnology & Medical Research industry. The company's beta value is 1.09. This indicates that the stock tends to outperform the index during upward trending markets but experiences larger declines during downward trending markets. Denali Therapeutics Inc’s latest ESG disclosure leads the Biotechnology & Medical Research industry, indicating outstanding, compliant performance across environmental management, social responsibility, and governance, which may help mitigate overall risk.

Score

Industry at a Glance

Previous score
5.43
Change
0
Beta vs S&P 500 index
1.09
VaR
+5.65%
240-Day Maximum Drawdown
+23.42%
240-Day Volatility
+62.02%

Return

Best Daily Return
60 days
+12.53%
120 days
+12.69%
5 years
+38.25%
Worst Daily Return
60 days
-12.17%
120 days
-12.17%
5 years
-15.27%
Sharpe Ratio
60 days
+0.90
120 days
+0.90
5 years
-0.16

Risk Assessment

Maximum Drawdown
240 days
+23.42%
3 years
+65.20%
5 years
+85.38%
Return-to-Drawdown Ratio
240 days
+1.84
3 years
-0.18
5 years
-0.18
Skewness
240 days
+0.19
3 years
+1.38
5 years
+0.93

Volatility

Realised Volatility
240 days
+62.02%
5 years
+62.42%
Standardised True Range
240 days
+5.11%
5 years
+7.92%
Downside Risk-Adjusted Return
120 days
+145.72%
240 days
+145.72%
Maximum Daily Upside Volatility
60 days
+47.33%
Maximum Daily Downside Volatility
60 days
+43.64%

Liquidity

Average Turnover Rate
60 days
+1.13%
120 days
+1.07%
5 years
--
Turnover Deviation
20 days
+49.32%
60 days
+36.92%
120 days
+29.88%

Peer Comparison

Biotechnology & Medical Research
Denali Therapeutics Inc
Denali Therapeutics Inc
DNLI
6.89 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
Alkermes Plc
ALKS
8.42 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Madrigal Pharmaceuticals Inc
Madrigal Pharmaceuticals Inc
MDGL
8.27 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
BioCryst Pharmaceuticals Inc
BioCryst Pharmaceuticals Inc
BCRX
8.27 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Day One Biopharmaceuticals Inc
Day One Biopharmaceuticals Inc
DAWN
8.26 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
IQVIA Holdings Inc
IQVIA Holdings Inc
IQV
8.21 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
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