Spyre drops on equity offering launch following inflammatory bowel drug trial

ReutersApr 13, 2026 9:16 PM

Spyre Therapeutics' SYRE.O shares drop nearly 2% after hours as it seeks equity following inflammatory bowel drug data

SYRE shares jumped 23.4% to finish at $63.27 on Mon after co said its drug, SPY001, showed a significant reduction in disease activity when testing patients with ulcerative colitis in a mid-stage trial

After the close, the Waltham, Massachusetts-based firm commences $300 mln stock offering

Jefferies, Goldman Sachs, Evercore and Guggenheim joint bookrunners

SYRE has ~78.8 mln shares outstanding for $5 bln current market cap

Including move on Mon, stock up 93% YTD and has surged more than fivefold over the past 12 months

9 analysts rate the stock "strong buy", the other 6 rate "buy"; median PT of $79 up from $59.50 a month ago, per LSEG data

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