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Drugmaker Ionis's Q2 revenue doubles, beats expectations; hikes guidance

ReutersJul 30, 2025 11:11 AM


Overview

  • Ionis Q2 2025 revenue doubles yr/yr, beating analyst expectations

  • Adjusted operating income beats expectations, driven by TRYNGOLZA launch

  • Co raises 2025 financial guidance, citing improved outlook and performance


Outlook

  • Ionis raises 2025 revenue guidance to $825-850 mln

  • Company expects TRYNGOLZA sales of $75-80 mln in 2025

  • Ionis anticipates sustained growth and positive cash flow


Result Drivers

  • TRYNGOLZA LAUNCH - Strong revenue growth driven by TRYNGOLZA's successful launch, generating $19 mln in Q2 sales

  • ROYALTY REVENUE - Increased royalty revenue from products like SPINRAZA and WAINUA contributed to revenue growth

  • COMMERCIAL INVESTMENTS - Operating expenses rose due to investments in commercializing TRYNGOLZA, donidalorsen, and WAINUA


Key Details

Metric

Beat/Miss

Actual

Consensus Estimate

Q2 Revenue

Beat

$452 mln

$295.20 mln (19 Analysts)

Q2 Net Income

$124 mln

Q2 Adjusted Operating Income

Beat

$170 mln

-$44.90 mln (12 Analysts)

Q2 Adjusted Operating Expenses

$282 mln

Q2 Operating Expenses

$312 mln

Q2 Operating Income

$140 mln


Analyst Coverage

  • The current average analyst rating on the shares is "buy" and the breakdown of recommendations is 18 "strong buy" or "buy", 8 "hold" and 1 "sell" or "strong sell"

  • The average consensus recommendation for the biotechnology & medical research peer group is "buy"

  • Wall Street's median 12-month price target for Ionis Pharmaceuticals Inc is $58.00, about 28.5% above its July 29 closing price of $41.48

Press Release: ID:nBwfCpmBa

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