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Spero Therapeutics Inc

SPRO

2.000USD

0.000
Close 09/19, 16:00ETQuotes delayed by 15 min
112.37MMarket Cap
LossP/E TTM

Spero Therapeutics Inc

2.000

0.000

TradingKey Stock Score

Overall Financial Health

Valuation Dimensions

Earnings Forecast

Price Momentum

Institutional Confidence

Risk Assessment

Peer Comparison

TradingKey Stock Score

Overall Financial Health

Valuation Dimensions

Earnings Forecast

Price Momentum

Institutional Confidence

Risk Assessment

Peer Comparison

TradingKey Stock Score

Currency: USD Updated: 2025-09-19

Key Insights

The company's fundamentals are relatively very healthy. Its valuation is considered fairly valued,and institutional recognition is very high. Over the past 30 days, multiple analysts have rated the company as a Hold. Despite a weak stock market performance, the company shows strong fundamentals and technicals. The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Industry Ranking
116 / 506
Overall Ranking
219 / 4720
Industry
Biotechnology & Medical Research

Support & Resistance

No Data

Score Analysis

Current score
Previous score

Analyst Rating

Based on 2 analysts
Hold
Current Rating
5.000
Target Price
+150.00%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Company Highlights

StrengthsRisks
Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on focused on identifying and developing novel treatments for rare diseases and multi-drug resistant (MDR) bacterial infections with unmet need. Its lead product candidate, SPR720, is an oral antimicrobial agent in development for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease, a rare orphan disease. Its partnership-directed programs consist of tebipenem HBr and SPR206. The tebipenem HBr is designed to be the oral carbapenem-class antibiotic for use to treat certain bacterial infections that cause complicated urinary tract infections (cUTIs), including pyelonephritis, caused by certain microorganisms, in adult patients who have limited oral treatment options. SPR206 is a direct acting intravenous (IV)-administered product candidate being developed as an option to treat MDR Gram-negative bacterial infections in the hospital setting.
Growing
The company is in a growing phase, with the latest annual income totaling USD 47.98M.
High Profit Growth
The company's net income leads the industry, with the latest annual income totaling USD 47.72.
Turnaround to Loss
The company's performance has turned to a loss, with the latest annual loss of USD 68.57M.%!(EXTRA int=2)
Undervalued
The company’s latest PE is -2.04, at a low 3-year percentile range.
Institutional Selling
The latest institutional holdings are 26.06M shares, decreasing 9.83% quarter-over-quarter.
Held by The Vanguard
Star Investor The Vanguard holds 1.95M shares of this stock.
Lower Market Activity
The company has less investor interest, with a 20-day turnover ratio of -0.05.

Financial Health

Currency: USD Updated: 2025-09-19

The company's current financial score is 9.13, which is higher than the Biotechnology & Medical Research industry's average of 6.93. Its financial status is robust, and its operating efficiency is high. Its latest quarterly revenue reached 14.19M, representing a year-over-year increase of 39.15%, while its net profit experienced a year-over-year increase of 90.48%.

Score

Industry at a Glance

Previous score
9.13
Change
0

Financials

8.86

Key Metrics

Cash and cash equivalents

Total assets

Total liabilities

Free cash flow

No Data

Quality of Earnings

10.00

Operational Efficiency

10.00

Growth Potential

9.24

Shareholder Returns

7.55

Company Valuation

Currency: USD Updated: 2025-09-19

The company’s current valuation score is 2.80, which is lower than the Biotechnology & Medical Research industry's average of 3.06. Its current P/E ratio is -2.04, which is -280.67% below the recent high of 3.69 and 66.61% above the recent low of -0.68.

Score

Industry at a Glance

Previous score
2.80
Change
0

Valuation Dimensions

P/E

P/B

P/S

P/CF

Industry Ranking 116/506
No Data

Earnings Forecast

Currency: USD Updated: 2025-09-19

The company’s current earnings forecast score is 6.00, which is lower than the Biotechnology & Medical Research industry's average of 8.03. The average price target for Spero Therapeutics Inc is 5.00, with a high of 5.00 and a low of 5.00.

Score

Industry at a Glance

Previous score
6.00
Change
0

Support & Resistance

No Data

Analyst Rating

Based on 2 analysts
Hold
Current Rating
5.000
Target Price
+150.00%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

554
Total
5
Median
6
Average
Company name
Ratings
Analysts
Spero Therapeutics Inc
SPRO
2
CRISPR Therapeutics AG
CRSP
30
Intellia Therapeutics Inc
NTLA
26
Exact Sciences Corp
EXAS
26
Ionis Pharmaceuticals Inc
IONS
26
IQVIA Holdings Inc
IQV
25
1
2
3
...
111

Financial Forecasting

EPS

Revenue

Net Profit

EBIT

No Data

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2025-09-19

The company’s current price momentum score is 7.27, which is higher than the Biotechnology & Medical Research industry's average of 6.58. Sideways: Currently, the stock price is trading between the resistance level at 2.19 and the support level at 1.81, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
7.27
Change
-0.06

Support & Resistance

No Data

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(2)
Neutral(3)
Buy(1)
Indicators
Value
Direction
MACD(12,26,9)
0.024
Neutral
RSI(14)
48.744
Neutral
STOCH(KDJ)(9,3,3)
50.235
Buy
ATR(14)
0.098
High Vlolatility
CCI(14)
7.499
Neutral
Williams %R
58.209
Sell
TRIX(12,20)
-0.311
Sell
StochRSI(14)
100.000
Overbought
Moving Average
Sell(2)
Neutral(0)
Buy(4)
Indicators
Value
Direction
MA5
1.936
Buy
MA10
1.945
Buy
MA20
1.974
Buy
MA50
2.133
Sell
MA100
2.034
Sell
MA200
1.446
Buy

Institutional Confidence

Currency: USD Updated: 2025-09-19

The company’s current institutional recognition score is 3.00, which is lower than the Biotechnology & Medical Research industry's average of 5.96. The latest institutional shareholding proportion is 46.61%, representing a quarter-over-quarter decrease of 5.03%. The largest institutional shareholder is The Vanguard, holding a total of 1.95M shares, representing 3.47% of shares outstanding, with 7.14% increase in holdings.

Score

Industry at a Glance

Previous score
3.00
Change
0

Institutional Shareholding

No Data

Shareholder Activity

Name
Shares Held
Chg %
GSK plc
9.19M
--
Pfizer Inc
2.36M
--
The Vanguard Group, Inc.
Star Investors
1.76M
--
Anson Funds Management LP.
3.80M
-1.07%
Alphabet, Inc.
889.98K
--
Renaissance Technologies LLC
Star Investors
970.91K
-12.18%
Hamed (Kamal)
788.12K
+36.72%
Geode Capital Management, L.L.C.
524.87K
+9.09%
BlackRock Institutional Trust Company, N.A.
472.81K
-0.42%
1
2

Risk Assessment

Currency: USD Updated: 2025-09-19

The company’s current risk assessment score is 3.18, which is lower than the Biotechnology & Medical Research industry's average of 3.33. The company's beta value is 1.48. This indicates that the stock tends to outperform the index during upward trending markets but experiences larger declines during downward trending markets.

Score

Industry at a Glance

Previous score
3.18
Change
0
Beta vs S&P 500 index
1.48
VaR
+6.48%
240-Day Maximum Drawdown
+57.89%
240-Day Volatility
+141.87%
Return
Best Daily Return
60 days
+7.27%
120 days
+244.57%
5 years
+244.57%
Worst Daily Return
60 days
-18.01%
120 days
-18.01%
5 years
-63.65%
Sharpe Ratio
60 days
-2.23
120 days
+1.24
5 years
+0.16
Risk Assessment
Maximum Drawdown
240 days
+57.89%
3 years
+72.41%
5 years
+97.46%
Return-to-Drawdown Ratio
240 days
+0.91
3 years
+0.02
5 years
-0.18
Skewness
240 days
+14.02
3 years
+21.97
5 years
+17.19
Volatility
Realised Volatility
240 days
+141.87%
5 years
+122.97%
Standardised True Range
240 days
+4.73%
5 years
+17.25%
Downside Risk-Adjusted Return
120 days
+887.22%
240 days
+887.22%
Maximum Daily Upside Volatility
60 days
+47.17%
Maximum Daily Downside Volatility
60 days
+53.47%
Liquidity
Average Turnover Rate
60 days
+1.94%
120 days
+4.22%
5 years
--
Turnover Deviation
20 days
-5.18%
60 days
+42.89%
120 days
+211.67%

Peer Comparison

Biotechnology & Medical Research
Spero Therapeutics Inc
Spero Therapeutics Inc
SPRO
5.96 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Krystal Biotech Inc
Krystal Biotech Inc
KRYS
8.14 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
Alkermes Plc
ALKS
7.85 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
ACADIA Pharmaceuticals Inc
ACADIA Pharmaceuticals Inc
ACAD
7.67 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Zymeworks Inc
Zymeworks Inc
ZYME
7.64 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Veracyte Inc
Veracyte Inc
VCYT
7.59 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
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