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Spero Therapeutics Inc

SPRO
2.420USD
+0.120+5.22%
Close 02/06, 16:00ETQuotes delayed by 15 min
136.27MMarket Cap
LossP/E TTM

Spero Therapeutics Inc

2.420
+0.120+5.22%
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison

TradingKey Stock Score of Spero Therapeutics Inc

Currency: USD Updated: 2026-02-06

Key Insights

Spero Therapeutics Inc's fundamentals are relatively very healthy, with an industry-leading ESG disclosure.and its growth potential is high.Its valuation is considered fairly valued, ranking 103 out of 392 in the Biotechnology & Medical Research industry.Institutional ownership is very high.Over the past month, multiple analysts have rated it as Hold, with the highest price target at 4.00.In the medium term, the stock price is expected to remain stable.Despite a weak stock market performance over the past month, the company shows strong fundamentals and technicals.The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Spero Therapeutics Inc's Score

Industry at a Glance

Industry Ranking
103 / 392
Overall Ranking
232 / 4521
Industry
Biotechnology & Medical Research

Support & Resistance

Relevant data have not been disclosed by the company yet.

Score Analysis

Current score
Previous score

Media Coverage

Last 24 hours
Coverage Level

Very Low
Very High
Neutral

Spero Therapeutics Inc Highlights

StrengthsRisks
Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on identifying and developing novel treatments for rare diseases and diseases caused by multi-drug resistant (MDR) bacterial infections with unmet need. Its product candidate SPR720 is an investigational, chemically stable phosphate ester prodrug that is converted in vivo to SPR719 for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease. Its clinical stage product candidate, tebipenem HBr is an investigational oral carbapenem antibiotic being developed for the treatment of complicated urinary tract infections (cUTIs) including acute pyelonephritis (AP) to help patients potentially reduce duration of in-patient therapy.
Growing
The company is in a growing phase, with the latest annual income totaling USD 47.98M.
High Profit Growth
The company's net income leads the industry, with the latest annual income totaling USD 47.98M.
Turnaround to Loss
The company's performance has turned to a loss, with the latest annual loss of USD .
Undervalued
The company’s latest PE is -3.05, at a low 3-year percentile range.
Institutional Selling
The latest institutional holdings are 9.24M shares, decreasing 24.79% quarter-over-quarter.
Held by Invesco
Star Investor Invesco holds 22.10K shares of this stock.
Lower Market Activity
The company has less investor interest, with a 20-day turnover ratio of -0.05.

Analyst Rating

Based on 1 analysts
Hold
Current Rating
4.000
Target Price
+73.91%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Financial Health

Currency: USD Updated: 2026-02-06

The current financial score of Spero Therapeutics Inc is 7.64, ranking 90 out of 392 in the Biotechnology & Medical Research industry. Its financial status is robust, and its operating efficiency is high. Its latest quarterly revenue reached 5.44M, representing a year-over-year decrease of 59.60%, while its net profit experienced a year-over-year decrease of 56.95%.

Score

Industry at a Glance

Previous score
7.64
Change
0

Financials

9.00

Key Metrics

Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
Relevant data have not been disclosed by the company yet.

Quality of Earnings

4.66

Operational Efficiency

10.00

Growth Potential

7.33

Shareholder Returns

7.22

Spero Therapeutics Inc's Company Valuation

Currency: USD Updated: 2026-02-06

The current valuation score of Spero Therapeutics Inc is 7.09, ranking 176 out of 392 in the Biotechnology & Medical Research industry. Its current P/E ratio is -3.05, which is -604.20% below the recent high of 15.36 and -33.20% above the recent low of -4.06.

Score

Industry at a Glance

Previous score
7.09
Change
0

Valuation Dimensions

P/E
P/B
P/S
P/CF
Industry Ranking 103/392
Relevant data have not been disclosed by the company yet.

Earnings Forecast

Currency: USD Updated: 2026-02-06

The current earnings forecast score of Spero Therapeutics Inc is 6.00, ranking 340 out of 392 in the Biotechnology & Medical Research industry. The average price target is 4.00, with a high of 4.00 and a low of 4.00.

Score

Industry at a Glance

Previous score
6.00
Change
0

Support & Resistance

Relevant data have not been disclosed by the company yet.

Analyst Rating

Based on 1 analysts
Hold
Current Rating
4.000
Target Price
+73.91%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

542
Total
6
Median
6
Average
Company name
Ratings
Analysts
Spero Therapeutics Inc
SPRO
1
CRISPR Therapeutics AG
CRSP
29
argenx SE
ARGX
26
IQVIA Holdings Inc
IQV
26
Intellia Therapeutics Inc
NTLA
24
Beigene Ltd
ONC
24
1
2
3
...
109

Financial Forecasting

EPS
Revenue
Net Profit
EBIT
Relevant data have not been disclosed by the company yet.

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2026-02-06

The current price momentum score of Spero Therapeutics Inc is 8.92, ranking 48 out of 392 in the Biotechnology & Medical Research industry. Currently, the stock price is trading between the resistance level at 2.63 and the support level at 2.16, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
7.18
Change
1.74

Support & Resistance

Relevant data have not been disclosed by the company yet.

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(2)
Neutral(2)
Buy(1)
Indicators
Value
Direction
MACD(12,26,9)
-0.008
Sell
RSI(14)
54.802
Neutral
STOCH(KDJ)(9,3,3)
62.247
Buy
ATR(14)
0.124
High Vlolatility
CCI(14)
53.858
Neutral
Williams %R
17.949
Overbought
TRIX(12,20)
-0.260
Sell
StochRSI(14)
100.000
Overbought
Moving Average
Sell(0)
Neutral(0)
Buy(6)
Indicators
Value
Direction
MA5
2.276
Buy
MA10
2.287
Buy
MA20
2.366
Buy
MA50
2.351
Buy
MA100
2.298
Buy
MA200
2.142
Buy

Institutional Confidence

Currency: USD Updated: 2026-02-06

The current institutional shareholding score of Spero Therapeutics Inc is 3.00, ranking 197 out of 392 in the Biotechnology & Medical Research industry. The latest institutional shareholding proportion is 16.40%, representing a quarter-over-quarter increase of 1.97%. The largest institutional shareholder is The Vanguard, holding a total of 2.08M shares, representing 3.70% of shares outstanding, with 17.22% increase in holdings.

Score

Industry at a Glance

Previous score
3.00
Change
0

Institutional Shareholding

Relevant data have not been disclosed by the company yet.

Shareholder Activity

Name
Shares Held
Chg %
GSK plc
9.19M
--
Pfizer Inc
2.36M
--
The Vanguard Group, Inc.
Star Investors
1.99M
+2.02%
Anson Funds Management LP.
1.60M
-0.74%
Renaissance Technologies LLC
Star Investors
1.45M
+74.58%
Alphabet, Inc.
889.98K
--
Geode Capital Management, L.L.C.
527.48K
+3.29%
BlackRock Institutional Trust Company, N.A.
433.55K
--
Rajavelu (Esther)
188.41K
-17.61%
Mahadevia (Ankit)
364.22K
-1.77%
1
2

Risk Assessment

Currency: USD Updated: 2026-02-06

The U.S. Dollar Index is currently in a neutral state, which has a neutral effect on the Biotechnology & Medical Research domestic-focused industry. The Dollar Index (DXY) measures the value of the U.S. dollar against a basket of major currencies, including the euro, yen, pound sterling, Canadian dollar, Swedish krona, and Swiss franc. The current risk assessment score of Spero Therapeutics Inc is 3.45, ranking 141 out of 392 in the Biotechnology & Medical Research industry. The company's beta value is 1.44. This indicates that the stock tends to outperform the index during upward trending markets but experiences larger declines during downward trending markets. with an industry-leading ESG disclosure.

Score

Industry at a Glance

Previous score
3.45
Change
0
Beta vs S&P 500 index
1.44
VaR
+6.06%
240-Day Maximum Drawdown
+39.80%
240-Day Volatility
+137.44%

Return

Best Daily Return
60 days
+7.01%
120 days
+7.03%
5 years
+244.57%
Worst Daily Return
60 days
-8.27%
120 days
-8.27%
5 years
-63.65%
Sharpe Ratio
60 days
+0.08
120 days
+1.12
5 years
+0.22

Risk Assessment

Maximum Drawdown
240 days
+39.80%
3 years
+71.28%
5 years
+97.13%
Return-to-Drawdown Ratio
240 days
+5.04
3 years
+0.32
5 years
-0.17
Skewness
240 days
+14.12
3 years
+21.96
5 years
+17.37

Volatility

Realised Volatility
240 days
+137.44%
5 years
+121.01%
Standardised True Range
240 days
+4.77%
5 years
+10.39%
Downside Risk-Adjusted Return
120 days
+175.62%
240 days
+175.62%
Maximum Daily Upside Volatility
60 days
+35.63%
Maximum Daily Downside Volatility
60 days
+32.57%

Liquidity

Average Turnover Rate
60 days
+1.94%
120 days
+4.22%
5 years
--
Turnover Deviation
20 days
-5.18%
60 days
+42.89%
120 days
+211.67%

Peer Comparison

Biotechnology & Medical Research
Spero Therapeutics Inc
Spero Therapeutics Inc
SPRO
6.60 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
Alkermes Plc
ALKS
8.60 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Ascendis Pharma A/S
Ascendis Pharma A/S
ASND
8.53 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Ionis Pharmaceuticals Inc
Ionis Pharmaceuticals Inc
IONS
8.38 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
IQVIA Holdings Inc
IQVIA Holdings Inc
IQV
8.37 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
BioCryst Pharmaceuticals Inc
BioCryst Pharmaceuticals Inc
BCRX
8.17 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
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