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Spruce Biosciences Inc

SPRB
72.400USD
+1.550+2.19%
Close 02/06, 16:00ETQuotes delayed by 15 min
40.80MMarket Cap
LossP/E TTM

Spruce Biosciences Inc

72.400
+1.550+2.19%
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison

TradingKey Stock Score of Spruce Biosciences Inc

Currency: USD Updated: 2026-02-06

Key Insights

Spruce Biosciences Inc's fundamentals are relatively very healthy, with an industry-leading ESG disclosure.and its growth potential is significant.Its valuation is considered fairly valued, ranking 203 out of 392 in the Biotechnology & Medical Research industry.Institutional ownership is very high.Over the past month, multiple analysts have rated it as Strong Buy, with the highest price target at 230.50.In the medium term, the stock price is expected to trend down.Despite a weak stock market performance over the past month, the company shows strong fundamentals.The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Spruce Biosciences Inc's Score

Industry at a Glance

Industry Ranking
203 / 392
Overall Ranking
396 / 4521
Industry
Biotechnology & Medical Research

Support & Resistance

Relevant data have not been disclosed by the company yet.

Score Analysis

Current score
Previous score

Media Coverage

Last 24 hours
Coverage Level

Very Low
Very High
Negative

Spruce Biosciences Inc Highlights

StrengthsRisks
Spruce Biosciences, Inc. is a late-stage biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. The Company has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The Company's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.
Growing
The company is in a growing phase, with the latest annual income totaling USD 4.91M.
Fairly Valued
The company’s latest PE is -0.86, at a medium 3-year percentile range.
Institutional Selling
The latest institutional holdings are 471.88K shares, decreasing 0.47% quarter-over-quarter.
Held by James Simons
Star Investor James Simons holds 0.00 shares of this stock.

Analyst Rating

Based on 4 analysts
Strong Buy
Current Rating
230.500
Target Price
+225.34%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Financial Health

Currency: USD Updated: 2026-02-06

The current financial score of Spruce Biosciences Inc is 8.26, ranking 50 out of 392 in the Biotechnology & Medical Research industry. Its financial status is robust, and its operating efficiency is high. Its latest quarterly revenue reached 0.00, representing a year-over-year decrease of 100.00%, while its net profit experienced a year-over-year decrease of 5.29%.

Score

Industry at a Glance

Previous score
6.82
Change
1.44

Financials

9.57

Key Metrics

Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
Relevant data have not been disclosed by the company yet.

Quality of Earnings

9.61

Operational Efficiency

10.00

Growth Potential

5.13

Shareholder Returns

6.99

Spruce Biosciences Inc's Company Valuation

Currency: USD Updated: 2026-02-06

No valuation score is currently available for Spruce Biosciences Inc. The Biotechnology & Medical Research industry's average is 7.04. Its current P/E ratio is -0.86, which is -99.57% below the recent high of -0.00 and -58.84% above the recent low of -1.37.

Score

Industry at a Glance

Previous score
0.00
Change
0

Valuation Dimensions

P/E
P/B
P/S
P/CF
Industry Ranking 203/392
Relevant data have not been disclosed by the company yet.

Earnings Forecast

Currency: USD Updated: 2026-02-06

The current earnings forecast score of Spruce Biosciences Inc is 8.00, ranking 164 out of 392 in the Biotechnology & Medical Research industry. The average price target is 209.50, with a high of 259.00 and a low of 160.00.

Score

Industry at a Glance

Previous score
8.00
Change
0

Support & Resistance

Relevant data have not been disclosed by the company yet.

Analyst Rating

Based on 4 analysts
Strong Buy
Current Rating
230.500
Target Price
+225.34%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

542
Total
6
Median
6
Average
Company name
Ratings
Analysts
Spruce Biosciences Inc
SPRB
4
CRISPR Therapeutics AG
CRSP
29
argenx SE
ARGX
26
IQVIA Holdings Inc
IQV
26
Intellia Therapeutics Inc
NTLA
24
Beigene Ltd
ONC
24
1
2
3
...
109

Financial Forecasting

EPS
Revenue
Net Profit
EBIT
Relevant data have not been disclosed by the company yet.

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2026-02-06

The current price momentum score of Spruce Biosciences Inc is 3.61, ranking 360 out of 392 in the Biotechnology & Medical Research industry. Currently, the stock price is trading between the resistance level at 83.53 and the support level at 65.15, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
3.54
Change
0.07

Support & Resistance

Relevant data have not been disclosed by the company yet.

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(4)
Neutral(1)
Buy(0)
Indicators
Value
Direction
MACD(12,26,9)
-0.745
Sell
RSI(14)
41.814
Neutral
STOCH(KDJ)(9,3,3)
23.979
Sell
ATR(14)
5.881
High Vlolatility
CCI(14)
-125.836
Sell
Williams %R
81.610
Oversold
TRIX(12,20)
-0.198
Sell
StochRSI(14)
15.083
Oversold
Moving Average
Sell(6)
Neutral(0)
Buy(0)
Indicators
Value
Direction
MA5
76.792
Sell
MA10
79.020
Sell
MA20
78.671
Sell
MA50
82.776
Sell
MA100
89.320
Sell
MA200
75.809
Sell

Institutional Confidence

Currency: USD Updated: 2026-02-06

Score

Industry at a Glance

Previous score
3.00
Change
0

Institutional Shareholding

Relevant data have not been disclosed by the company yet.

Shareholder Activity

Name
Shares Held
Chg %
Ikarian Capital LLC
121.36K
+810.26%
Citadel Advisors LLC
109.65K
--
Squadron Capital Management LLC
70.00K
--
Boone (Peter David)
68.18K
--
Abingworth Management Limited
38.62K
--
Armistice Capital LLC
28.92K
--
HealthCap AB
27.20K
-31.49%
Cable Car Capital LLC
26.67K
--
Szwarcberg (Javier B M.D.)
19.00K
+100.59%
1
2

Risk Assessment

Currency: USD Updated: 2026-02-06

The U.S. Dollar Index is currently in a neutral state, which has a neutral effect on the Biotechnology & Medical Research domestic-focused industry. The Dollar Index (DXY) measures the value of the U.S. dollar against a basket of major currencies, including the euro, yen, pound sterling, Canadian dollar, Swedish krona, and Swiss franc. The current risk assessment score of Spruce Biosciences Inc is 2.57, ranking 219 out of 392 in the Biotechnology & Medical Research industry. The company's beta value is 3.64. This indicates that the stock tends to outperform the index during upward trending markets but experiences larger declines during downward trending markets. with an industry-leading ESG disclosure.

Score

Industry at a Glance

Previous score
2.57
Change
0
Beta vs S&P 500 index
--
VaR
--
240-Day Maximum Drawdown
--
240-Day Volatility
--

Return

Best Daily Return
60 days
--
120 days
--
5 years
--
Worst Daily Return
60 days
--
120 days
--
5 years
--
Sharpe Ratio
60 days
--
120 days
--
5 years
--

Risk Assessment

Maximum Drawdown
240 days
--
3 years
--
5 years
--
Return-to-Drawdown Ratio
240 days
--
3 years
--
5 years
--
Skewness
240 days
--
3 years
--
5 years
--

Volatility

Realised Volatility
240 days
--
5 years
--
Standardised True Range
240 days
--
5 years
--
Downside Risk-Adjusted Return
120 days
--
240 days
--
Maximum Daily Upside Volatility
60 days
--
Maximum Daily Downside Volatility
60 days
--

Liquidity

Average Turnover Rate
60 days
--
120 days
--
5 years
--
Turnover Deviation
20 days
--
60 days
--
120 days
--

Peer Comparison

Biotechnology & Medical Research
Spruce Biosciences Inc
Spruce Biosciences Inc
SPRB
4.94 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
Alkermes Plc
ALKS
8.60 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Ascendis Pharma A/S
Ascendis Pharma A/S
ASND
8.53 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Ionis Pharmaceuticals Inc
Ionis Pharmaceuticals Inc
IONS
8.38 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
IQVIA Holdings Inc
IQVIA Holdings Inc
IQV
8.37 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
BioCryst Pharmaceuticals Inc
BioCryst Pharmaceuticals Inc
BCRX
8.17 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
View more
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