The current institutional shareholding score of Ionis Pharmaceuticals Inc is 10.00, ranking 1 out of 389 in the Biotechnology & Medical Research industry. The latest institutional shareholding proportion is 119.51%, representing a quarter-over-quarter increase of 9.44%. The largest institutional shareholder is Tweedy Browne, holding a total of 2.23M shares, representing 1.37% of shares outstanding, with 0.51% decrease in holdings.