13.16BMarket Cap
LossP/E TTM
Ionis Pharmaceuticals Inc
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score of Ionis Pharmaceuticals Inc
Currency: USD Updated: 2025-12-05 Key Insights
The company's fundamentals are relatively stable. Its valuation is considered fairly valued,and institutional recognition is very high. Over the past 30 days, multiple analysts have rated the company as a Buy. The company is performing well in the stock market, with strong fundamentals and technicals supporting the current trend. The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.
Ionis Pharmaceuticals Inc's Score
Score Analysis
Current score
Previous score
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.
Ionis Pharmaceuticals Inc Highlights
StrengthsRisks
Financial Health
Currency: USD Updated: 2025-12-05The company's current financial score is 8.24, which is higher than the Biotechnology & Medical Research industry's average of 6.92. Its financial status is weak, and its operating efficiency is high. Its latest quarterly revenue reached 156.72M, representing a year-over-year increase of 17.12%, while its net profit experienced a year-over-year increase of 8.45%.
Key Metrics
Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
Relevant data have not been disclosed by the company yet.
Key Metrics
Total revenue
Operating profit
Total assets
SG&A
Relevant data have not been disclosed by the company yet.
Key Metrics
Cash flow from operating activities
Income after tax
Relevant data have not been disclosed by the company yet.
Key Metrics
Cash flow from operating activities
Total revenue
Relevant data have not been disclosed by the company yet.
Key Metrics
Relevant data have not been disclosed by the company yet.
Ionis Pharmaceuticals Inc's Company Valuation
Currency: USD Updated: 2025-12-05The company’s current valuation score is 7.20, which is higher than the Biotechnology & Medical Research industry's average of 7.05. Its current P/E ratio is -50.80, which is -83.15% below the recent high of -8.56 and -1.29% above the recent low of -51.46.
Valuation Dimensions
Industry Ranking 9/403
Relevant data have not been disclosed by the company yet.
Earnings Forecast
Currency: USD Updated: 2025-12-05The company’s current earnings forecast score is 8.25, which is higher than the Biotechnology & Medical Research industry's average of 8.02. The average price target for Ionis Pharmaceuticals Inc is 85.50, with a high of 110.00 and a low of 46.00.
Support & Resistance
Relevant data have not been disclosed by the company yet.
Strong Buy
Buy
Hold
Sell
Strong Sell
Ionis Pharmaceuticals Inc
IONS
24
CRISPR Therapeutics AG
CRSP
30
Intellia Therapeutics Inc
NTLA
25
Financial Forecasting
Relevant data have not been disclosed by the company yet.
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.
Price Momentum
Currency: USD Updated: 2025-12-05The company’s current price momentum score is 9.60, which is higher than the Biotechnology & Medical Research industry's average of 7.13. Sideways: Currently, the stock price is trading between the resistance level at 87.97 and the support level at 71.02, making it suitable for range-bound swing trading.
Support & Resistance
Relevant data have not been disclosed by the company yet.
Indicators
The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.
This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.
Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.
Institutional Confidence
Currency: USD Updated: 2025-12-05The company’s current institutional recognition score is 10.00, which is higher than the Biotechnology & Medical Research industry's average of 5.15. The latest institutional shareholding proportion is 106.78%, representing a quarter-over-quarter decrease of 8.22%. The largest institutional shareholder is The Vanguard, holding a total of 16.44M shares, representing 10.15% of shares outstanding, with 1.18% decrease in holdings.
Institutional Shareholding
Relevant data have not been disclosed by the company yet.
Shareholder Activity
Fidelity Management & Research Company LLC
T. Rowe Price Investment Management, Inc.
BlackRock Institutional Trust Company, N.A.
Wellington Management Company, LLP
Bellevue Asset Management AG
State Street Investment Management (US)
Two Sigma Investments, LP
Risk Assessment
Currency: USD Updated: 2025-12-05The company’s current risk assessment score is 6.84, which is higher than the Biotechnology & Medical Research industry's average of 3.48. The company's beta value is 0.31. This indicates that the stock tends to underperform the index during upward trending markets but experiences smaller declines during downward trending markets.
Beta vs S&P 500 index
0.28
240-Day Maximum Drawdown
+30.17%
240-Day Volatility
+47.14%
Volatility
Downside Risk-Adjusted Return
Maximum Daily Upside Volatility
Maximum Daily Downside Volatility
Biotechnology & Medical Research
Ionis Pharmaceuticals Inc
IONS
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
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FAQs
How does TradingKey generate the Stock Score of Ionis Pharmaceuticals Inc?
The TradingKey Stock Score provides a comprehensive assessment of Ionis Pharmaceuticals Inc based on 34 indicators derived from over 100 underlying data points. These indicators are categorised into six key dimensions: financial health, company profile, earnings forecasts, price momentum, institutional confidence, and risk assessment, collectively providing investors with a thorough analysis of Ionis Pharmaceuticals Inc’s performance and outlook.
How do we generate the financial health score of Ionis Pharmaceuticals Inc?
To generate the financial health score of Ionis Pharmaceuticals Inc, we analyse various key financial indicators across several core dimensions, including financial fundamentals, earnings quality, operational efficiency, growth potential, and shareholder returns. By integrating these comprehensive data, the financial health score not only reflects Ionis Pharmaceuticals Inc's overall stability, operational efficiency, and growth potential but also captures the investment returns delivered to shareholders. This score aims to support rational decision-making for investors and other stakeholders. A higher score indicates a better financial health of Ionis Pharmaceuticals Inc.
How do we generate the company valuation score of Ionis Pharmaceuticals Inc?
To generate the company valuation score of Ionis Pharmaceuticals Inc, we use several key financial ratios, including P/E, P/B, P/S, and P/CF. These metrics compare Ionis Pharmaceuticals Inc’s market value to its earnings, assets, sales, and cash flow, serving as core indicators for assessing company value. By analysing these ratios in an all-round manner, the valuation score reflects not only the market’s current perception of Ionis Pharmaceuticals Inc’s value but also its future profitability and growth potential, thereby supporting more informed investment decisions. A higher score indicates a fairer valuation of Ionis Pharmaceuticals Inc.
How do we generate the earnings forecast score of Ionis Pharmaceuticals Inc?
To calculate the earnings forecast score of Ionis Pharmaceuticals Inc, we consider various key indicators such as analyst ratings, financial forecasts, support and resistance levels, and peer comparisons:Current ratings and price targets directly reflect analysts’ expectations, while the upside space indicates their views on the stock’s growth potential.Financial metrics like earnings per share (EPS), revenue, net income, and earnings before interest and taxes (EBIT) are core measures for assessing profitability.By analysing the high, median, and low ranges of the target price, we can identify price trends and determine key support and resistance levels.Comparing these indicators against peers provides context for the stock’s performance and helps
anchor more realistic expectations.These factors together form a comprehensive earnings forecast score that accurately reflects the stock’s expected financial performance and growth potential. A higher score suggests that analysts have a more optimistic outlook on Ionis Pharmaceuticals Inc’s future.
How do we generate the price momentum score of Ionis Pharmaceuticals Inc?
When generating the price momentum score for Ionis Pharmaceuticals Inc, we examine momentum indicators including support and resistance levels as well as volume metrics.Support levels represent price points where buying interest is strong enough to prevent further declines, while resistance levels indicate prices where selling pressure may hinder upward movement. By analysing typical price volume alongside total volume, we assess overall market activity and liquidity. These indicators help identify price trends and potential shifts, enabling more accurate predictions of future earnings.This comprehensive approach can reflect market sentiment and enable rational forecasts of Ionis Pharmaceuticals Inc’s prices. A higher score indicates a more stable short-term price trend for Ionis Pharmaceuticals Inc.
How do we generate the institutional confidence score of Ionis Pharmaceuticals Inc?
To generate the institutional confidence score of Ionis Pharmaceuticals Inc, we analyse both the proportion of shares held by institutions and the number of shares they own. A higher institutional ownership percentage indicates strong confidence of professional investors, which is generally a positive signal about Ionis Pharmaceuticals Inc’s potential. By examining the number of shares held, we gain deeper insight into institutions’ commitment and attitude toward the stock, as institutional investors typically conduct thorough analysis before making investment decisions. Understanding institutional confidence helps us refine earnings forecasts and provides a more reliable perspective on the company’s future performance and market stability. A higher score indicates greater institutional endorsement of Ionis Pharmaceuticals Inc.
How do we generate the risk management score of Ionis Pharmaceuticals Inc?
To assess the risk management score of Ionis Pharmaceuticals Inc, we examine multiple key indicators related to returns, risk, volatility, and liquidity.The highest and lowest daily returns reflect the potential size of gains and losses, while the Sharpe ratio measures risk-adjusted return performance. On the risk side, we analyse maximum drawdown and the return-to-drawdown ratio to identify extreme loss scenarios. Skewness helps assess the distribution of returns and whether performance may be biased. Volatility indicators—such as realised volatility and standardised true range—reveal price fluctuations. Downside risk-adjusted returns provide insight into potential losses and gains. Lastly, liquidity metrics like average turnover rate and turnover deviation indicate how actively the stock is traded.These indicators together provide a multi-dimensional understanding of Ionis Pharmaceuticals Inc’s risk-return profile, serving as core factors of the risk management score. A higher score indicates lower risk on the side of Ionis Pharmaceuticals Inc.
