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Fulcrum Therapeutics Inc

FULC
6.730USD
-0.210-3.03%
Close 03/27, 16:00ETQuotes delayed by 15 min
363.21MMarket Cap
LossP/E TTM

Fulcrum Therapeutics Inc

6.730
-0.210-3.03%
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison

TradingKey Stock Score of Fulcrum Therapeutics Inc

Currency: USD Updated: 2026-03-27

Key Insights

Fulcrum Therapeutics Inc's fundamentals are relatively weak, with an industry-leading ESG disclosure.and its growth potential is high.Its valuation is considered fairly valued, ranking 59 out of 391 in the Biotechnology & Medical Research industry.Institutional ownership is very high.Over the past month, multiple analysts have rated it as Buy, with the highest price target at 18.89.In the medium term, the stock price is expected to trend down.Despite a weak stock market performance over the past month, the company shows strong fundamentals and technicals.The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Fulcrum Therapeutics Inc's Score

Industry at a Glance

Industry Ranking
59 / 391
Overall Ranking
168 / 4542
Industry
Biotechnology & Medical Research

Support & Resistance

Relevant data have not been disclosed by the company yet.

Score Analysis

Current score
Previous score

Media Coverage

Last 24 hours
Coverage Level

Very Low
Very High
Neutral

Fulcrum Therapeutics Inc Highlights

StrengthsRisks
Fulcrum Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The Company's lead clinical program is pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease (SCD). It uses technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. In addition to its product candidates, the Company has developed a discovery approach that it employs to systematically identify and validate cellular drug targets that can potentially modulate gene expression to treat known root causes of genetically defined rare diseases. The Company continues to advance its program for the potential treatment of inherited aplastic anemias, such as Diamond-Blackfan anemia (DBA), Shwachman-Diamond syndrome, and Fanconi anemia.
Fairly Valued
The company’s latest PE is -5.69, at a medium 3-year percentile range.
Held by Invesco
Star Investor Invesco holds 390.02K shares of this stock.
Lower Market Activity
The company has less investor interest, with a 20-day turnover ratio of -0.35.

Analyst Rating

Based on 10 analysts
Buy
Current Rating
18.889
Target Price
+172.17%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Financial Health

Currency: USD Updated: 2026-03-27

The current financial score of Fulcrum Therapeutics Inc is 7.26, ranking 110 out of 391 in the Biotechnology & Medical Research industry. Its financial status is weak, and its operating efficiency is high.

Score

Industry at a Glance

Previous score
7.26
Change
0

Financials

2.27

Key Metrics

Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
Relevant data have not been disclosed by the company yet.

Quality of Earnings

7.51

Operational Efficiency

10.00

Growth Potential

9.28

Shareholder Returns

7.22

Fulcrum Therapeutics Inc's Company Valuation

Currency: USD Updated: 2026-03-27

The current valuation score of Fulcrum Therapeutics Inc is 6.75, ranking 224 out of 391 in the Biotechnology & Medical Research industry. Its current P/E ratio is -5.69, which is -82.11% below the recent high of -1.02 and -21609.47% above the recent low of -1236.18.

Score

Industry at a Glance

Previous score
6.75
Change
0

Valuation Dimensions

P/E
P/B
P/S
P/CF
Industry Ranking 59/391
Relevant data have not been disclosed by the company yet.

Earnings Forecast

Currency: USD Updated: 2026-03-27

The current earnings forecast score of Fulcrum Therapeutics Inc is 8.00, ranking 163 out of 391 in the Biotechnology & Medical Research industry. The average price target is 20.00, with a high of 25.00 and a low of 5.00.

Score

Industry at a Glance

Previous score
8.00
Change
0

Support & Resistance

Relevant data have not been disclosed by the company yet.

Analyst Rating

Based on 10 analysts
Buy
Current Rating
18.889
Target Price
+172.17%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

548
Total
6
Median
6
Average
Company name
Ratings
Analysts
Fulcrum Therapeutics Inc
FULC
10
CRISPR Therapeutics AG
CRSP
29
IQVIA Holdings Inc
IQV
27
argenx SE
ARGX
26
Intellia Therapeutics Inc
NTLA
24
Beigene Ltd
ONC
24
1
2
3
...
110

Financial Forecasting

EPS
Revenue
Net Profit
EBIT
Relevant data have not been disclosed by the company yet.

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2026-03-27

The current price momentum score of Fulcrum Therapeutics Inc is 6.60, ranking 187 out of 391 in the Biotechnology & Medical Research industry. Currently, the stock price is trading between the resistance level at 8.00 and the support level at 6.01, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
6.81
Change
-0.21

Support & Resistance

Relevant data have not been disclosed by the company yet.

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(2)
Neutral(3)
Buy(0)
Indicators
Value
Direction
MACD(12,26,9)
0.047
Neutral
RSI(14)
31.470
Neutral
STOCH(KDJ)(9,3,3)
19.322
Oversold
ATR(14)
0.417
High Vlolatility
CCI(14)
-76.353
Neutral
Williams %R
90.230
Oversold
TRIX(12,20)
-1.388
Sell
StochRSI(14)
54.928
Sell
Moving Average
Sell(6)
Neutral(0)
Buy(0)
Indicators
Value
Direction
MA5
6.848
Sell
MA10
6.984
Sell
MA20
7.461
Sell
MA50
9.196
Sell
MA100
9.900
Sell
MA200
8.779
Sell

Institutional Confidence

Currency: USD Updated: 2026-03-27

The current institutional shareholding score of Fulcrum Therapeutics Inc is 10.00, ranking 1 out of 391 in the Biotechnology & Medical Research industry. The latest institutional shareholding proportion is 143.06%, representing a quarter-over-quarter decrease of 1.03%. The largest institutional shareholder is The Vanguard, holding a total of 3.56M shares, representing 5.34% of shares outstanding, with 10.41% decrease in holdings.

Score

Industry at a Glance

Previous score
10.00
Change
0

Institutional Shareholding

Relevant data have not been disclosed by the company yet.

Shareholder Activity

Name
Shares Held
Chg %
Suvretta Capital Management, LLC
5.38M
+5.86%
RA Capital Management, LP
6.05M
-40.82%
TCG Crossover Management, LLC
5.25M
--
Nantahala Capital Management, LLC
4.67M
+8.92%
BlackRock Institutional Trust Company, N.A.
3.16M
-15.07%
The Vanguard Group, Inc.
Star Investors
3.00M
-4.67%
D. E. Shaw & Co., L.P.
1.45M
+23.18%
1
2

Risk Assessment

Currency: USD Updated: 2026-03-27

The U.S. Dollar Index is currently in a neutral state, which has a neutral effect on the Biotechnology & Medical Research domestic-focused industry. The Dollar Index (DXY) measures the value of the U.S. dollar against a basket of major currencies, including the euro, yen, pound sterling, Canadian dollar, Swedish krona, and Swiss franc. The current risk assessment score of Fulcrum Therapeutics Inc is 2.65, ranking 209 out of 391 in the Biotechnology & Medical Research industry. The company's beta value is 3.32. This indicates that the stock tends to outperform the index during upward trending markets but experiences larger declines during downward trending markets. with an industry-leading ESG disclosure.

Score

Industry at a Glance

Previous score
2.65
Change
0
Beta vs S&P 500 index
3.29
VaR
+7.32%
240-Day Maximum Drawdown
+54.11%
240-Day Volatility
+96.65%

Return

Best Daily Return
60 days
+7.78%
120 days
+45.96%
5 years
+125.33%
Worst Daily Return
60 days
-21.21%
120 days
-21.21%
5 years
-61.13%
Sharpe Ratio
60 days
-3.00
120 days
-0.23
5 years
+0.49

Risk Assessment

Maximum Drawdown
240 days
+54.11%
3 years
+79.08%
5 years
+92.70%
Return-to-Drawdown Ratio
240 days
+2.78
3 years
+0.45
5 years
-0.04
Skewness
240 days
+2.51
3 years
-0.29
5 years
+4.18

Volatility

Realised Volatility
240 days
+96.65%
5 years
+119.28%
Standardised True Range
240 days
+9.63%
5 years
+10.53%
Downside Risk-Adjusted Return
120 days
-45.84%
240 days
-45.84%
Maximum Daily Upside Volatility
60 days
+48.30%
Maximum Daily Downside Volatility
60 days
+54.04%

Liquidity

Average Turnover Rate
60 days
+1.24%
120 days
+1.15%
5 years
--
Turnover Deviation
20 days
-35.41%
60 days
-8.91%
120 days
-15.30%

Peer Comparison

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Fulcrum Therapeutics Inc
Fulcrum Therapeutics Inc
FULC
7.01 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
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ALKS
8.42 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Madrigal Pharmaceuticals Inc
Madrigal Pharmaceuticals Inc
MDGL
8.27 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
BioCryst Pharmaceuticals Inc
BioCryst Pharmaceuticals Inc
BCRX
8.27 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Day One Biopharmaceuticals Inc
Day One Biopharmaceuticals Inc
DAWN
8.26 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
IQVIA Holdings Inc
IQVIA Holdings Inc
IQV
8.21 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
View more
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