The current institutional shareholding score of Bicycle Therapeutics PLC is 5.00, ranking 133 out of 389 in the Biotechnology & Medical Research industry. The latest institutional shareholding proportion is 67.23%, representing a quarter-over-quarter decrease of 41.32%. The largest institutional shareholder is James Simons, holding a total of 0.00 shares, representing 1.40% of shares outstanding, with 27.99% decrease in holdings.