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Upstream Bio Inc

UPB
23.780USD
+0.280+1.19%
Close 11/11, 16:00ETQuotes delayed by 15 min
1.28BMarket Cap
LossP/E TTM

Upstream Bio Inc

23.780
+0.280+1.19%
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison

TradingKey Stock Score of Upstream Bio Inc

Currency: USD Updated: 2025-11-11

Key Insights

The company's fundamentals are relatively healthy. Its valuation is considered fairly valued,and institutional recognition is very high. Over the past 30 days, multiple analysts have rated the company as a Buy. The company is performing well in the stock market, with strong fundamentals and technicals supporting the current trend. The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Upstream Bio Inc's Score

Industry at a Glance

Industry Ranking
60 / 407
Overall Ranking
155 / 4608
Industry
Biotechnology & Medical Research

Support & Resistance

No Data

Score Analysis

Current score
Previous score

Analyst Rating

Based on 5 analysts
Buy
Current Rating
47.000
Target Price
+100.00%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Upstream Bio Inc Highlights

StrengthsRisks
Upstream Bio, Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist in development that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin. The Company has advanced this highly potent monoclonal antibody into separate Phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and plans to initiate development of chronic obstructive pulmonary disease (COPD).
High Growth
The company's revenue has grown steadily over the past 3 years, averaging 95.54% year-on-year.
Growing
The company is in a growing phase, with the latest annual income totaling USD 2.37M.
High Profit Growth
The company's net income leads the industry, with the latest annual income totaling USD 2.37M.
Fairly Valued
The company’s latest PE is -10.33, at a medium 3-year percentile range.
Institutional Buying
The latest institutional holdings are 50.98M shares, increasing 1.65% quarter-over-quarter.
Held by CI Select Canadian Equity Fund
Star Investor CI Select Canadian Equity Fund holds 51.00 shares of this stock.

Financial Health

Currency: USD Updated: 2025-11-11

The company's current financial score is 6.77, which is lower than the Biotechnology & Medical Research industry's average of 6.92. Its financial status is stable, and its operating efficiency is low. Its latest quarterly revenue reached 683.00K, representing a year-over-year increase of 12.52%, while its net profit experienced a year-over-year increase of 60.45%.

Score

Industry at a Glance

Previous score
6.77
Change
0

Financials

7.61

Key Metrics

Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
No Data

Quality of Earnings

7.89

Operational Efficiency

2.68

Growth Potential

8.39

Shareholder Returns

7.29

Upstream Bio Inc's Company Valuation

Currency: USD Updated: 2025-11-11

The company’s current valuation score is 6.75, which is lower than the Biotechnology & Medical Research industry's average of 7.05. Its current P/E ratio is -10.33, which is -55.69% below the recent high of -4.58 and -95.65% above the recent low of -20.21.

Score

Industry at a Glance

Previous score
6.75
Change
0

Valuation Dimensions

P/E
P/B
P/S
P/CF
Industry Ranking 60/407
No Data

Earnings Forecast

Currency: USD Updated: 2025-11-11

The company’s current earnings forecast score is 8.40, which is higher than the Biotechnology & Medical Research industry's average of 8.00. The average price target for Upstream Bio Inc is 47.00, with a high of 47.00 and a low of 47.00.

Score

Industry at a Glance

Previous score
8.40
Change
0

Support & Resistance

No Data

Analyst Rating

Based on 5 analysts
Buy
Current Rating
47.000
Target Price
+100.00%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

521
Total
5
Median
6
Average
Company name
Ratings
Analysts
Upstream Bio Inc
UPB
5
CRISPR Therapeutics AG
CRSP
30
IQVIA Holdings Inc
IQV
25
Ionis Pharmaceuticals Inc
IONS
25
argenx SE
ARGX
25
Intellia Therapeutics Inc
NTLA
25
1
2
3
...
104

Financial Forecasting

EPS
Revenue
Net Profit
EBIT
No Data

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2025-11-11

The company’s current price momentum score is 7.49, which is higher than the Biotechnology & Medical Research industry's average of 6.78. Sideways: Currently, the stock price is trading between the resistance level at 27.08 and the support level at 20.30, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
7.49
Change
0

Support & Resistance

No Data

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(1)
Neutral(5)
Buy(1)
Indicators
Value
Direction
MACD(12,26,9)
-0.504
Neutral
RSI(14)
57.384
Neutral
STOCH(KDJ)(9,3,3)
34.396
Neutral
ATR(14)
1.619
High Vlolatility
CCI(14)
-7.792
Neutral
Williams %R
53.061
Neutral
TRIX(12,20)
0.982
Sell
StochRSI(14)
65.904
Buy
Moving Average
Sell(1)
Neutral(0)
Buy(5)
Indicators
Value
Direction
MA5
23.574
Buy
MA10
24.374
Sell
MA20
23.381
Buy
MA50
20.252
Buy
MA100
17.197
Buy
MA200
12.963
Buy

Institutional Confidence

Currency: USD Updated: 2025-11-11

The company’s current institutional recognition score is 10.00, which is higher than the Biotechnology & Medical Research industry's average of 5.13. The latest institutional shareholding proportion is 94.34%, representing a quarter-over-quarter decrease of 9.72%. The largest institutional shareholder is The Vanguard, holding a total of 2.44M shares, representing 4.52% of shares outstanding, with 164.76% increase in holdings.

Score

Industry at a Glance

Previous score
10.00
Change
0

Institutional Shareholding

No Data

Shareholder Activity

Name
Shares Held
Chg %
Fidelity Management & Research Company LLC
7.69M
+7.45%
OrbiMed Advisors, LLC
5.69M
--
Access Industries, Inc.
5.49M
--
Altshuler Shaham Ltd.
3.39M
+0.02%
Decheng Capital LLC
3.29M
--
Norges Bank Investment Management (NBIM)
969.92K
-3.01%
TCG Crossover Management, LLC
2.80M
--
HBM Partners AG
2.72M
--
Enavate Sciences GP, LLC
2.46M
--
The Vanguard Group, Inc.
Star Investors
2.17M
+139.34%
1
2

Risk Assessment

Currency: USD Updated: 2025-11-11

The company’s current risk assessment score is 4.27, which is higher than the Biotechnology & Medical Research industry's average of 3.47. The company's beta value is 0.00. This indicates that the stock tends to underperform the index during upward trending markets but experiences smaller declines during downward trending markets.

Score

Industry at a Glance

Previous score
4.27
Change
0
Beta vs S&P 500 index
--
VaR
--
240-Day Maximum Drawdown
+74.54%
240-Day Volatility
+97.42%

Return

Best Daily Return
60 days
+18.27%
120 days
+18.27%
5 years
--
Worst Daily Return
60 days
-7.67%
120 days
-7.70%
5 years
--
Sharpe Ratio
60 days
+1.61
120 days
+3.12
5 years
--

Risk Assessment

Maximum Drawdown
240 days
+74.54%
3 years
--
5 years
--
Return-to-Drawdown Ratio
240 days
+0.37
3 years
--
5 years
--
Skewness
240 days
+0.09
3 years
--
5 years
--

Volatility

Realised Volatility
240 days
+97.42%
5 years
--
Standardised True Range
240 days
+4.91%
5 years
--
Downside Risk-Adjusted Return
120 days
+735.57%
240 days
+735.57%
Maximum Daily Upside Volatility
60 days
+57.52%
Maximum Daily Downside Volatility
60 days
+41.08%

Liquidity

Average Turnover Rate
60 days
+0.90%
120 days
+0.75%
5 years
--
Turnover Deviation
20 days
--
60 days
--
120 days
--

Peer Comparison

Biotechnology & Medical Research
Upstream Bio Inc
Upstream Bio Inc
UPB
7.31 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
Alkermes Plc
ALKS
8.65 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Zymeworks Inc
Zymeworks Inc
ZYME
8.63 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
NewAmsterdam Pharma Company NV
NewAmsterdam Pharma Company NV
NAMS
8.58 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Insmed Inc
Insmed Inc
INSM
8.56 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
IQVIA Holdings Inc
IQVIA Holdings Inc
IQV
8.54 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
View more
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