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Upstream Bio Inc

UPB
26.200USD
+0.200+0.77%
Close 02/06, 16:00ETQuotes delayed by 15 min
1.41BMarket Cap
LossP/E TTM

Upstream Bio Inc

26.200
+0.200+0.77%
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison

TradingKey Stock Score of Upstream Bio Inc

Currency: USD Updated: 2026-02-06

Key Insights

Upstream Bio Inc's fundamentals are relatively very healthy, with an industry-leading ESG disclosure.and its growth potential is high.Its valuation is considered fairly valued, ranking 64 out of 392 in the Biotechnology & Medical Research industry.Institutional ownership is very high.Over the past month, multiple analysts have rated it as Buy, with the highest price target at 48.50.In the medium term, the stock price is expected to trend up.Despite a weak stock market performance over the past month, the company shows strong fundamentals and technicals.The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Upstream Bio Inc's Score

Industry at a Glance

Industry Ranking
64 / 392
Overall Ranking
184 / 4521
Industry
Biotechnology & Medical Research

Support & Resistance

Relevant data have not been disclosed by the company yet.

Score Analysis

Current score
Previous score

Media Coverage

Last 24 hours
Coverage Level

Very Low
Very High
Negative

Upstream Bio Inc Highlights

StrengthsRisks
Upstream Bio, Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. It has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.
High Growth
The company's revenue has grown steadily over the past 3 years, averaging 95.54% year-on-year.
Growing
The company is in a growing phase, with the latest annual income totaling USD 2.37M.
High Profit Growth
The company's net income leads the industry, with the latest annual income totaling USD 2.37M.
Fairly Valued
The company’s latest PE is -11.38, at a medium 3-year percentile range.
Institutional Buying
The latest institutional holdings are 50.17M shares, increasing 1.07% quarter-over-quarter.
Held by CI Select Canadian Equity Fund
Star Investor CI Select Canadian Equity Fund holds 117.00 shares of this stock.

Analyst Rating

Based on 8 analysts
Buy
Current Rating
48.500
Target Price
+86.54%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Financial Health

Currency: USD Updated: 2026-02-06

The current financial score of Upstream Bio Inc is 6.41, ranking 259 out of 392 in the Biotechnology & Medical Research industry. Its financial status is robust, and its operating efficiency is low. Its latest quarterly revenue reached 683.00K, representing a year-over-year increase of 12.52%, while its net profit experienced a year-over-year increase of 60.45%.

Score

Industry at a Glance

Previous score
6.41
Change
0

Financials

8.23

Key Metrics

Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
Relevant data have not been disclosed by the company yet.

Quality of Earnings

7.18

Operational Efficiency

2.83

Growth Potential

6.76

Shareholder Returns

7.07

Upstream Bio Inc's Company Valuation

Currency: USD Updated: 2026-02-06

The current valuation score of Upstream Bio Inc is 6.75, ranking 228 out of 392 in the Biotechnology & Medical Research industry. Its current P/E ratio is -11.38, which is -59.78% below the recent high of -4.58 and -77.58% above the recent low of -20.21.

Score

Industry at a Glance

Previous score
6.75
Change
0

Valuation Dimensions

P/E
P/B
P/S
P/CF
Industry Ranking 64/392
Relevant data have not been disclosed by the company yet.

Earnings Forecast

Currency: USD Updated: 2026-02-06

The current earnings forecast score of Upstream Bio Inc is 8.25, ranking 147 out of 392 in the Biotechnology & Medical Research industry. The average price target is 43.00, with a high of 75.00 and a low of 35.00.

Score

Industry at a Glance

Previous score
8.25
Change
0

Support & Resistance

Relevant data have not been disclosed by the company yet.

Analyst Rating

Based on 8 analysts
Buy
Current Rating
48.500
Target Price
+86.54%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

542
Total
6
Median
6
Average
Company name
Ratings
Analysts
Upstream Bio Inc
UPB
8
CRISPR Therapeutics AG
CRSP
29
argenx SE
ARGX
26
IQVIA Holdings Inc
IQV
26
Intellia Therapeutics Inc
NTLA
24
Beigene Ltd
ONC
24
1
2
3
...
109

Financial Forecasting

EPS
Revenue
Net Profit
EBIT
Relevant data have not been disclosed by the company yet.

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2026-02-06

The current price momentum score of Upstream Bio Inc is 6.62, ranking 210 out of 392 in the Biotechnology & Medical Research industry. Currently, the stock price is trading between the resistance level at 31.30 and the support level at 23.49, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
6.59
Change
0.03

Support & Resistance

Relevant data have not been disclosed by the company yet.

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(1)
Neutral(2)
Buy(0)
Indicators
Value
Direction
MACD(12,26,9)
-1.302
Neutral
RSI(14)
38.400
Neutral
STOCH(KDJ)(9,3,3)
9.906
Oversold
ATR(14)
2.120
Low Volatility
CCI(14)
-232.266
Oversold
Williams %R
95.259
Oversold
TRIX(12,20)
0.104
Sell
StochRSI(14)
5.316
Oversold
Moving Average
Sell(4)
Neutral(0)
Buy(2)
Indicators
Value
Direction
MA5
28.462
Sell
MA10
29.742
Sell
MA20
30.501
Sell
MA50
29.079
Sell
MA100
25.242
Buy
MA200
18.970
Buy

Institutional Confidence

Currency: USD Updated: 2026-02-06

The current institutional shareholding score of Upstream Bio Inc is 10.00, ranking 1 out of 392 in the Biotechnology & Medical Research industry. The latest institutional shareholding proportion is 92.85%, representing a quarter-over-quarter decrease of 1.58%. The largest institutional shareholder is The Vanguard, holding a total of 2.38M shares, representing 4.41% of shares outstanding, with 160.94% increase in holdings.

Score

Industry at a Glance

Previous score
10.00
Change
0

Institutional Shareholding

Relevant data have not been disclosed by the company yet.

Shareholder Activity

Name
Shares Held
Chg %
Fidelity Management & Research Company LLC
7.69M
+7.45%
OrbiMed Advisors, LLC
5.69M
--
Access Industries, Inc.
5.49M
--
Decheng Capital LLC
3.29M
--
Norges Bank Investment Management (NBIM)
969.92K
-3.01%
Enavate Sciences GP, LLC
2.46M
--
Bain Capital Life Sciences Investors, LLC
2.44M
+6.28%
The Vanguard Group, Inc.
Star Investors
2.17M
+139.34%
HBM Partners AG
2.72M
--
TCG Crossover Management, LLC
2.80M
--
1
2

Risk Assessment

Currency: USD Updated: 2026-02-06

The U.S. Dollar Index is currently in a neutral state, which has a neutral effect on the Biotechnology & Medical Research domestic-focused industry. The Dollar Index (DXY) measures the value of the U.S. dollar against a basket of major currencies, including the euro, yen, pound sterling, Canadian dollar, Swedish krona, and Swiss franc. The current risk assessment score of Upstream Bio Inc is 4.93, ranking 61 out of 392 in the Biotechnology & Medical Research industry. The company's beta value is 0.00. This indicates that the stock tends to underperform the index during upward trending markets but experiences smaller declines during downward trending markets. with an industry-leading ESG disclosure.

Score

Industry at a Glance

Previous score
4.93
Change
0
Beta vs S&P 500 index
--
VaR
--
240-Day Maximum Drawdown
+38.50%
240-Day Volatility
+88.81%

Return

Best Daily Return
60 days
+10.67%
120 days
+18.27%
5 years
--
Worst Daily Return
60 days
-13.70%
120 days
-13.70%
5 years
--
Sharpe Ratio
60 days
+1.12
120 days
+1.33
5 years
--

Risk Assessment

Maximum Drawdown
240 days
+38.50%
3 years
--
5 years
--
Return-to-Drawdown Ratio
240 days
+5.68
3 years
--
5 years
--
Skewness
240 days
+0.36
3 years
--
5 years
--

Volatility

Realised Volatility
240 days
+88.81%
5 years
--
Standardised True Range
240 days
+4.83%
5 years
--
Downside Risk-Adjusted Return
120 days
+240.32%
240 days
+240.32%
Maximum Daily Upside Volatility
60 days
+51.35%
Maximum Daily Downside Volatility
60 days
+47.14%

Liquidity

Average Turnover Rate
60 days
+0.90%
120 days
+0.75%
5 years
--
Turnover Deviation
20 days
--
60 days
--
120 days
--

Peer Comparison

Biotechnology & Medical Research
Upstream Bio Inc
Upstream Bio Inc
UPB
7.08 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Alkermes Plc
Alkermes Plc
ALKS
8.60 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Ascendis Pharma A/S
Ascendis Pharma A/S
ASND
8.53 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Ionis Pharmaceuticals Inc
Ionis Pharmaceuticals Inc
IONS
8.38 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
IQVIA Holdings Inc
IQVIA Holdings Inc
IQV
8.37 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
BioCryst Pharmaceuticals Inc
BioCryst Pharmaceuticals Inc
BCRX
8.17 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
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