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Septerna Inc

SEPN
20.050USD
-0.550-2.67%
Close 11/03, 16:00ETQuotes delayed by 15 min
893.59MMarket Cap
LossP/E TTM

Septerna Inc

20.050
-0.550-2.67%
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison
TradingKey Stock Score
Overall Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Peer Comparison

TradingKey Stock Score of Septerna Inc

Currency: USD Updated: 2025-11-03

Key Insights

The company's fundamentals are relatively very healthy. Its valuation is considered fairly valued,and institutional recognition is very high. Over the past 30 days, multiple analysts have rated the company as a Buy. Despite an average stock market performance, the company shows strong fundamentals and technicals. The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Septerna Inc's Score

Industry at a Glance

Industry Ranking
85 / 407
Overall Ranking
197 / 4617
Industry
Biotechnology & Medical Research

Support & Resistance

No Data

Score Analysis

Current score
Previous score

Analyst Rating

Based on 5 analysts
Buy
Current Rating
23.000
Target Price
+11.65%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Septerna Inc Highlights

StrengthsRisks
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with significant unmet needs. It is focused in major therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Growing
The company is in a growing phase, with the latest annual income totaling USD 1.07M.
High Profit Growth
The company's net income leads the industry, with the latest annual income totaling USD 1.07M.
Turnaround to Loss
The company's performance has turned to a loss, with the latest annual loss of USD .
Undervalued
The company’s latest PE is -2.64, at a low 3-year percentile range.
Institutional Selling
The latest institutional holdings are 44.83M shares, decreasing 12.71% quarter-over-quarter.
Held by The Vanguard
Star Investor The Vanguard holds 1.41M shares of this stock.

Financial Health

Currency: USD Updated: 2025-11-03

The company's current financial score is 6.23, which is lower than the Biotechnology & Medical Research industry's average of 6.92. Its financial status is robust, and its operating efficiency is low.

Score

Industry at a Glance

Previous score
6.23
Change
0

Financials

9.06

Key Metrics

Cash and cash equivalents
Total assets
Total liabilities
Free cash flow
No Data

Quality of Earnings

7.24

Operational Efficiency

2.57

Growth Potential

5.19

Shareholder Returns

7.11

Septerna Inc's Company Valuation

Currency: USD Updated: 2025-11-03

The company’s current valuation score is 6.52, which is lower than the Biotechnology & Medical Research industry's average of 7.05. Its current P/E ratio is -2.64, which is -74.39% below the recent high of -0.68 and -23.41% above the recent low of -3.26.

Score

Industry at a Glance

Previous score
6.52
Change
0

Valuation Dimensions

P/E
P/B
P/S
P/CF
Industry Ranking 85/407
No Data

Earnings Forecast

Currency: USD Updated: 2025-11-03

The company’s current earnings forecast score is 7.60, which is lower than the Biotechnology & Medical Research industry's average of 8.01. The average price target for Septerna Inc is 25.00, with a high of 26.00 and a low of 18.00.

Score

Industry at a Glance

Previous score
7.60
Change
0

Support & Resistance

No Data

Analyst Rating

Based on 5 analysts
Buy
Current Rating
23.000
Target Price
+11.65%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

521
Total
5
Median
6
Average
Company name
Ratings
Analysts
Septerna Inc
SEPN
5
CRISPR Therapeutics AG
CRSP
30
Ionis Pharmaceuticals Inc
IONS
25
argenx SE
ARGX
25
Intellia Therapeutics Inc
NTLA
25
IQVIA Holdings Inc
IQV
25
1
2
3
...
104

Financial Forecasting

EPS
Revenue
Net Profit
EBIT
No Data

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2025-11-03

The company’s current price momentum score is 6.55, which is lower than the Biotechnology & Medical Research industry's average of 6.58. Sideways: Currently, the stock price is trading between the resistance level at 23.45 and the support level at 18.13, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
6.59
Change
-0.04

Support & Resistance

No Data

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(2)
Neutral(2)
Buy(0)
Indicators
Value
Direction
MACD(12,26,9)
-1.046
Neutral
RSI(14)
45.624
Neutral
STOCH(KDJ)(9,3,3)
18.646
Sell
ATR(14)
1.268
High Vlolatility
CCI(14)
-210.039
Oversold
Williams %R
89.773
Oversold
TRIX(12,20)
0.662
Sell
StochRSI(14)
0.000
Oversold
Moving Average
Sell(3)
Neutral(0)
Buy(3)
Indicators
Value
Direction
MA5
21.280
Sell
MA10
21.579
Sell
MA20
22.164
Sell
MA50
18.179
Buy
MA100
14.900
Buy
MA200
11.825
Buy

Institutional Confidence

Currency: USD Updated: 2025-11-03

The company’s current institutional recognition score is 10.00, which is higher than the Biotechnology & Medical Research industry's average of 5.15. The latest institutional shareholding proportion is 100.55%, representing a quarter-over-quarter decrease of 7.46%. The largest institutional shareholder is The Vanguard, holding a total of 1.41M shares, representing 3.17% of shares outstanding, with 43.00% increase in holdings.

Score

Industry at a Glance

Previous score
10.00
Change
0

Institutional Shareholding

No Data

Shareholder Activity

Name
Shares Held
Chg %
Third Rock Ventures, LLC
10.43M
--
RA Capital Management, LP
7.00M
--
Driehaus Capital Management, LLC
4.68M
+0.44%
BVF Partners L.P.
4.40M
--
Samsara BioCapital, LLC
3.15M
--
Invus Public Equities Advisors, LLC
2.20M
--
Goldman Sachs & Company, Inc.
1.42M
-2.28%
The Vanguard Group, Inc.
Star Investors
1.41M
+42.14%
BlackRock Institutional Trust Company, N.A.
1.25M
+7.82%
Avoro Capital Advisors LLC
1.24M
-7.48%
1
2

Risk Assessment

Currency: USD Updated: 2025-11-03

The company’s current risk assessment score is 4.75, which is higher than the Biotechnology & Medical Research industry's average of 3.47. The company's beta value is 0.00. This indicates that the stock tends to underperform the index during upward trending markets but experiences smaller declines during downward trending markets.

Score

Industry at a Glance

Previous score
4.75
Change
0
Beta vs S&P 500 index
--
VaR
--
240-Day Maximum Drawdown
+81.47%
240-Day Volatility
+155.54%

Return

Best Daily Return
60 days
+14.10%
120 days
+50.97%
5 years
--
Worst Daily Return
60 days
-5.69%
120 days
-7.81%
5 years
--
Sharpe Ratio
60 days
+4.19
120 days
+2.80
5 years
--

Risk Assessment

Maximum Drawdown
240 days
+81.47%
3 years
--
5 years
--
Return-to-Drawdown Ratio
240 days
-0.14
3 years
--
5 years
--
Skewness
240 days
+0.33
3 years
--
5 years
--

Volatility

Realised Volatility
240 days
+155.54%
5 years
--
Standardised True Range
240 days
+5.54%
5 years
--
Downside Risk-Adjusted Return
120 days
+924.98%
240 days
+924.98%
Maximum Daily Upside Volatility
60 days
+52.25%
Maximum Daily Downside Volatility
60 days
+37.11%

Liquidity

Average Turnover Rate
60 days
+0.75%
120 days
+1.56%
5 years
--
Turnover Deviation
20 days
--
60 days
--
120 days
--

Peer Comparison

Biotechnology & Medical Research
Septerna Inc
Septerna Inc
SEPN
6.84 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Zymeworks Inc
Zymeworks Inc
ZYME
8.55 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
CytomX Therapeutics Inc
CytomX Therapeutics Inc
CTMX
8.51 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Insmed Inc
Insmed Inc
INSM
8.49 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
NewAmsterdam Pharma Company NV
NewAmsterdam Pharma Company NV
NAMS
8.49 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Amicus Therapeutics Inc
Amicus Therapeutics Inc
FOLD
8.47 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
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