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Karyopharm Therapeutics Inc

KPTI

5.410USD

-0.320-5.58%
Close 09/19, 16:00ETQuotes delayed by 15 min
46.78MMarket Cap
LossP/E TTM

Karyopharm Therapeutics Inc

5.410

-0.320-5.58%

TradingKey Stock Score

Overall Financial Health

Valuation Dimensions

Earnings Forecast

Price Momentum

Institutional Confidence

Risk Assessment

Peer Comparison

TradingKey Stock Score

Overall Financial Health

Valuation Dimensions

Earnings Forecast

Price Momentum

Institutional Confidence

Risk Assessment

Peer Comparison

TradingKey Stock Score

Currency: USD Updated: 2025-09-19

Key Insights

The company's fundamentals are relatively stable. Its valuation is considered undervalued,and institutional recognition is very high. Over the past 30 days, multiple analysts have rated the company as a Buy. Despite a good stock market performance and outperforming fundamentals, the technicals don't support the current trend. The stock price is trading sideways between the support and resistance levels, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Industry Ranking
92 / 175
Overall Ranking
278 / 4720
Industry
Pharmaceuticals

Support & Resistance

No Data

Score Analysis

Current score
Previous score

Analyst Rating

Based on 6 analysts
Buy
Current Rating
17.600
Target Price
+207.16%
Upside Space
Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Company Highlights

StrengthsRisks
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. It is developing and commercializing small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including multiple myeloma, endometrial cancer, mycosis fungoides (MF) and diffuse large B-cell lymphoma (DLBCL). The Company’s product candidate, eltanexor, oral SINE compound that, like selinexor, selectively blocks the nuclear export protein XPO1.
Overvalued
The company’s latest PE is -0.37, at a high 3-year percentile range.
Institutional Selling
The latest institutional holdings are 4.20M shares, decreasing 29.40% quarter-over-quarter.
Held by The Vanguard
Star Investor The Vanguard holds 518.27K shares of this stock.

Financial Health

Currency: USD Updated: 2025-09-19

The company's current financial score is 7.90, which is higher than the Pharmaceuticals industry's average of 7.84. Its financial status is weak, and its operating efficiency is high. Its latest quarterly revenue reached 37.93M, representing a year-over-year decrease of 11.35%, while its net profit experienced a year-over-year decrease of 256.57%.

Score

Industry at a Glance

Previous score
7.90
Change
0

Financials

5.43

Key Metrics

Cash and cash equivalents

Total assets

Total liabilities

Free cash flow

No Data

Quality of Earnings

7.36

Operational Efficiency

10.00

Growth Potential

9.25

Shareholder Returns

7.49

Company Valuation

Currency: USD Updated: 2025-09-19

The company’s current valuation score is 1.20, which is lower than the Pharmaceuticals industry's average of 2.06. Its current P/E ratio is -0.39, which is -4.93% below the recent high of -0.37 and -67.94% above the recent low of -0.65.

Score

Industry at a Glance

Previous score
1.20
Change
0

Valuation Dimensions

P/E

P/B

P/S

P/CF

Industry Ranking 92/175
No Data

Earnings Forecast

Currency: USD Updated: 2025-09-19

The company’s current earnings forecast score is 8.00, which is higher than the Pharmaceuticals industry's average of 7.78. The average price target for Karyopharm Therapeutics Inc is 15.00, with a high of 30.00 and a low of 8.00.

Score

Industry at a Glance

Previous score
8.00
Change
0

Support & Resistance

No Data

Analyst Rating

Based on 6 analysts
Buy
Current Rating
17.600
Target Price
+207.16%
Upside Space
Strong Buy
Buy
Hold
Sell
Strong Sell

Peer Comparison

179
Total
5
Median
8
Average
Company name
Ratings
Analysts
Karyopharm Therapeutics Inc
KPTI
6
Biogen Inc
BIIB
35
Amgen Inc
AMGN
34
Vertex Pharmaceuticals Inc
VRTX
32
Alnylam Pharmaceuticals Inc
ALNY
32
Eli Lilly and Co
LLY
31
1
2
3
...
36

Financial Forecasting

EPS

Revenue

Net Profit

EBIT

No Data

Data disclaimer: Analyst ratings and target prices are provided by LSEG for informational purposes only and do not constitute investment advice.

Price Momentum

Currency: USD Updated: 2025-09-19

The company’s current price momentum score is 4.89, which is lower than the Pharmaceuticals industry's average of 6.84. Sideways: Currently, the stock price is trading between the resistance level at 7.36 and the support level at 4.89, making it suitable for range-bound swing trading.

Score

Industry at a Glance

Previous score
4.89
Change
0.17

Support & Resistance

No Data

Indicators

The Indicators feature provides value and direction analysis for various instruments under a selection of technical indicators, together with a technical summary.

This feature includes nine of the commonly used technical indicators: MACD, RSI, KDJ, StochRSI, ATR, CCI, WR, TRIX and MA. You may also adjust the timeframe depending on your needs.

Please note that technical analysis is only part of investment reference, and there is no absolute standard for using numerical values to assess direction. The results are for reference only, and we are not responsible for the accuracy of the indicator calculations and summaries.

Indicators
Sell(2)
Neutral(2)
Buy(0)
Indicators
Value
Direction
MACD(12,26,9)
-0.426
Neutral
RSI(14)
41.429
Neutral
STOCH(KDJ)(9,3,3)
12.146
Oversold
ATR(14)
0.507
Low Volatility
CCI(14)
-192.638
Sell
Williams %R
95.767
Oversold
TRIX(12,20)
0.532
Sell
StochRSI(14)
0.000
Oversold
Moving Average
Sell(4)
Neutral(0)
Buy(2)
Indicators
Value
Direction
MA5
5.948
Sell
MA10
6.162
Sell
MA20
6.574
Sell
MA50
5.319
Buy
MA100
5.131
Buy
MA200
6.684
Sell

Institutional Confidence

Currency: USD Updated: 2025-09-19

The company’s current institutional recognition score is 3.00, which is lower than the Pharmaceuticals industry's average of 6.26. The latest institutional shareholding proportion is 48.66%, representing a quarter-over-quarter decrease of 1.57%. The largest institutional shareholder is The Vanguard, holding a total of 518.27K shares, representing 5.98% of shares outstanding, with 1.46% decrease in holdings.

Score

Industry at a Glance

Previous score
3.00
Change
0

Institutional Shareholding

No Data

Shareholder Activity

Name
Shares Held
Chg %
T. Rowe Price Investment Management, Inc.
139.65K
--
The Vanguard Group, Inc.
Star Investors
510.29K
-0.00%
J. Wood Capital Advisors LLC
458.13K
--
Adage Capital Management, L.P.
421.32K
-0.00%
Eversept Partners, LP
257.15K
+84.67%
J.P. Morgan Securities LLC
147.42K
+700.61%
Citadel Advisors LLC
206.91K
-0.00%
Palo Alto Investors LP
324.03K
-0.95%
BlackRock Institutional Trust Company, N.A.
188.02K
-0.53%
BofA Global Research (US)
132.91K
+1132.80%
1
2

Risk Assessment

Currency: USD Updated: 2025-09-19

The company’s current risk assessment score is 3.05, which is lower than the Pharmaceuticals industry's average of 4.07. The company's beta value is 0.34. This indicates that the stock tends to underperform the index during upward trending markets but experiences smaller declines during downward trending markets.

Score

Industry at a Glance

Previous score
3.05
Change
0
Beta vs S&P 500 index
0.34
VaR
+8.46%
240-Day Maximum Drawdown
+76.16%
240-Day Volatility
+105.65%
Return
Best Daily Return
60 days
+27.31%
120 days
+27.31%
5 years
+37.37%
Worst Daily Return
60 days
-11.11%
120 days
-20.00%
5 years
-39.75%
Sharpe Ratio
60 days
+1.53
120 days
+0.84
5 years
-0.39
Risk Assessment
Maximum Drawdown
240 days
+76.16%
3 years
+95.89%
5 years
+98.67%
Return-to-Drawdown Ratio
240 days
-0.75
3 years
-0.32
5 years
-0.20
Skewness
240 days
+0.96
3 years
+0.79
5 years
+0.37
Volatility
Realised Volatility
240 days
+105.65%
5 years
+97.44%
Standardised True Range
240 days
+11.97%
5 years
+78.34%
Downside Risk-Adjusted Return
120 days
+168.02%
240 days
+168.02%
Maximum Daily Upside Volatility
60 days
+122.09%
Maximum Daily Downside Volatility
60 days
+67.40%
Liquidity
Average Turnover Rate
60 days
+1.90%
120 days
+1.64%
5 years
--
Turnover Deviation
20 days
-78.36%
60 days
-83.31%
120 days
-85.58%

Peer Comparison

Pharmaceuticals
Karyopharm Therapeutics Inc
Karyopharm Therapeutics Inc
KPTI
5.37 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Royalty Pharma PLC
Royalty Pharma PLC
RPRX
8.01 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
United Therapeutics Corp
United Therapeutics Corp
UTHR
7.91 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Neurocrine Biosciences Inc
Neurocrine Biosciences Inc
NBIX
7.79 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Regeneron Pharmaceuticals Inc
Regeneron Pharmaceuticals Inc
REGN
7.77 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
Supernus Pharmaceuticals Inc
Supernus Pharmaceuticals Inc
SUPN
7.71 /10
Score
Financial Health
Valuation Dimensions
Earnings Forecast
Price Momentum
Institutional Confidence
Risk Assessment
View more
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