Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company’s pipeline includes two clinical-stage synthetic lethality programs. Its lead programs are APR-1051, an oral, small-molecule inhibitor of WEE1 kinase, and ATRN-119, a small-molecule ATR inhibitor, both in clinical development for solid tumor indications. Its ATRN-119 is an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR). The ATR kinase is a master regulator of Deoxyribonucleic Acid (DNA) damage response, with roles in cell cycle control and DNA repair following replication stress. It is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute. It also has an early-stage program, in the lead optimization stage, for an undisclosed DNA-damage response (DDR) target.
Growing
The company is in a growing phase, with the latest annual income totaling USD 285.76K.
Fairly Valued
The company’s latest PE is -0.50, at a medium 3-year percentile range.
Institutional Buying
The latest institutional holdings are 2.34M shares, increasing 18.00% quarter-over-quarter.
Held by James Simons
Star Investor James Simons holds 20.92K shares of this stock.
Lower Market Activity
The company has less investor interest, with a 20-day turnover ratio of -0.73.