랩코프(LH) 2026년 3분기 실적 발표회: 마진 확대로 가이던스 상향
랩콥 홀딩스(NYSE: LH)는 2026년 3분기 전사 매출이 전년 동기 대비 6.9% 증가한 38억 달러, 자체 성장률은 5.5%를 기록했다고 발표했다. 조정 영업이익률은 15.0%로 60bp 확대되었고, 조정 주당순이익(EPS)은 14.5% 증가한 4.78달러를 기록했다.
진단 부문 매출은 6.5% 증가한 29억 달러, 바이오파마 연구소 서비스(BLS) 매출은 8.5% 증가한 8억 6,700만 달러를 기록했다. 경영진은 2026년 연간 전사 매출 및 조정 EPS 가이던스의 중간값을 각각 6,500만 달러, 0.18달러 상향 조정했다.
한편, 임시 PAMA 수가표로 인해 2027년에 약 1억 2,500만 달러 규모의 영향이 발생할 것으로 추정되며, 이는 주로 전통적인 메디케어 및 메디케이드 환급에 영향을 미칠 것으로 예상된다. 경영진은 4가지 주요 상쇄 요인을 통해 대응할 계획이다.
핵심 요약
- 랩콥 홀딩스(NYSE: LH)는 2026년 3분기 매출이 전년 동기 대비 6.9% 증가한 38억 달러를 기록했다고 발표했다. 이 중 자체 성장률은 5.5%였다.
- 조정 영업이익률은 15.0%로 60베이시스포인트(bp) 확대되며 6분기 연속 전사 이익률 개선세를 이어갔다. 조정 주당순이익(EPS)은 14.5% 증가한 4.78달러를 기록했다.
- 진단 부문 매출은 3.1%의 자체 검사량 성장과 1.3%의 우호적인 가격 및 제품 믹스 효과에 힘입어 6.5% 증가한 29억 달러를 기록했다.
- 바이오파마 연구소 서비스(BLS) 매출은 8.5% 증가한 8억 6,700만 달러를 기록했다. 중앙 연구소 서비스의 11.3% 성장에 힘입어 자체 고정환율 기준 매출 성장률은 9.6%에 달했다.
- 경영진은 2026년 연간 전사 매출 및 조정 EPS 가이던스의 중간값을 각각 6,500만 달러, 0.18달러 상향 조정했다.
- 랩콥은 임시 PAMA 수가표로 인해 2027년에 약 1억 2,500만 달러 규모의 영향이 발생할 것으로 추정하고 있으며, 이는 주로 전통적인 메디케어 및 메디케이드 수가 환급에 영향을 미칠 것으로 예상된다.
핵심 재무 데이터
| 지표 | 2026년 3분기 | 전년 동기 대비 변동 / 주석 |
|---|---|---|
| 전사 매출 | 38억 달러 | 6.9% 증가, 자체 성장률 5.5% |
| 조정 영업이익 | 5억 7,000만 달러 | 전년 동기(5억 1,300만 달러) 대비 증가 |
| 조정 영업이익률 | 15.0% | 14.4%에서 60bp 확대 |
| 조정 EPS | $4.78 | 14.5% 증가 |
| 잉여현금흐름(FCF) | 4억 1,200만 달러 | 주로 운전자본 개선에 힘입어 전년 동기(2억 8,100만 달러) 대비 증가 |
| 진단 부문 매출 | 29억 달러 | 6.5% 증가 |
| 진단 부문 조정 영업이익률 | 16.7% | 40bp 확대 |
| 바이오파마 연구소 서비스(BLS) 매출 | 8억 6,700만 달러 | 8.5% 증가 |
| BLS 조정 영업이익률 | 18.3% | 180bp 확대 |
| BLS 수주잔고 | 89억 달러 | 향후 12개월 동안 약 28억 달러가 매출로 전환될 것으로 예상됨 |
| BLS 수주출하비율(Book-to-Bill) | 1.13 | 직전 12개월(TTM) 수주출하비율 1.10 |
랩콥은 해당 분기 동안 인수합병(M&A)에 2억 5,600만 달러를 투입하고 배당금으로 5,800만 달러를 지급했다. 3분기 말 기준 현금 및 현금성 자산은 2억 6,200만 달러, 총부채는 59억 달러이다. 자사주 매입 승인 잔액은 약 14억 달러가 남아 있다.
사업 및 영업 실적
진단 부문
진단 부문은 3.1%의 검사량 증가와 1.3%의 우호적인 가격 및 제품 믹스에 힘입어 4.4%의 자체 매출 성장을 기록했다. 인수합병은 부문 성장에 2.2%포인트를 기여했다. 경영진은 가격 및 믹스 기여도의 대부분을 접수건당 검사 수 증가 덕분으로 돌렸다.
경영진에 따르면 전문 검사 분야는 전체 진단 시장보다 약 3배 빠른 속도로 지속 성장을 보였다. 특수 진단 검사(Esoteric testing) 비중은 2024년 1분기 진단 매출의 38%에서 2026년 3분기 42%로 확대되었다.
랩콥은 진행성 흑색종에 대한 FDA 승인 동반진단 검사와 알츠하이머병에 대한 FDA 승인 pTau217 혈액 검사를 통해 전문 포트폴리오를 확장했다. 또한 나이트 암 연구소(Knight Cancer Institute)와 함께 근침윤성 방광암의 재발을 감지하기 위한 플라즈마 디텍트 지놈(Plasma Detect Genome) MRD 검사를 평가하는 임상 연구를 발표했다.
바이오파마 연구소 서비스(BLS)
BLS의 자체 고정환율 기준 매출은 9.6% 증가했다. 중앙 연구소 서비스는 기저 수요 증대와 연구 개시 시점의 호조에 힘입어 11.3% 성장했다. 초기 개발(Early Development) 부문은 5% 성장했다.
경영진은 대형 제약사들을 중심으로 중앙 연구소 수요가 견조하게 유지되었다고 밝혔다. 종양학 분야가 지속적으로 기여한 가운데, GLP-1 관련 활동을 포함한 심혈관·대사 질환 임상시험이 추가적인 기회를 창출했다. 또한 랩콥은 추가 성장을 지원할 충분한 역량을 갖추고 있으며 인디애나폴리스에 연구소 시설을 건립 중이라고 덧붙였다.
인수합병 및 파트너십
랩콥은 MLM 메디컬 랩스(MLM Medical Labs)를 인수하여 중앙 연구소 사업 부문이 북미, 유럽, 아시아 및 아프리카 전역에 100% 지분을 소유한 네트워크를 확보하게 되었다.
분기 종료 후, 랩콥은 바이오리퍼런스 헬스(BioReference Health)의 일부 연구소 자산, 미리어드 제네틱스(Myriad Genetics)의 산전 건강 검사 사업, 그리고 밀레니엄 헬스(Millennium Health)를 인수하기 위한 계약을 체결했다. 경영진은 각 거래가 인수 첫해에 조정 EPS를 증가시키고 3년 차까지 자본비용을 회수할 것으로 기대하고 있다.
바이오리퍼런스 자산 인수로 인수 후 첫 12개월 동안 약 2억 5,000만 달러의 매출, 진단 부문 평균을 소폭 상회하는 조정 영업이익률, 금융 비용을 포함해 약 0.15달러의 조정 EPS 기여가 예상된다. 거래 종결은 승인 및 관례적인 조건에 따라 2027년 중반경으로 예상된다.
미리어드 제네틱스 자산 인수는 약 1억 6,000만 달러의 매출을 추가할 것으로 예상된다. 경영진은 첫해에 소폭의 조정 EPS 증가가 나타나고, 2년 차 말까지 진단 부문 평균 수준의 이익률을 달성할 것으로 전망한다. 거래 종결은 승인 및 관례적인 조건에 따라 2027년 초로 예상된다.
경영진 가이던스
| 2026년 연간 가이던스 | 수정된 범위 / 목표 |
|---|---|
| 전사 매출 성장률 | 5.9% ~ 6.7% |
| 진단 부문 매출 성장률 | 5.5% ~ 6.2% |
| BLS 매출 성장률 | 7.4% ~ 8.4% |
| 조정 EPS | $18.30 ~ $18.70 |
| 잉여현금흐름(FCF) | 12억 4,000만 달러 ~ 13억 6,000만 달러 |
| 자본적 지출(CAPEX) | 매출의 약 4% |
| 조정 세율 | 약 23% |
| 런치패드(LaunchPad) 절감액 | 1억 2,500만 달러 |
전사 매출 가이던스의 중간값은 50bp, 즉 6,500만 달러 상향 조정되었다. 업데이트된 전망에는 이전 40bp에서 하향 조정된 30bp의 환율 수혜가 포함되어 있다.
경영진은 중앙 연구소의 지속적인 호조에 힘입어 BLS 매출 가이던스 중간값을 190bp 상향 조정했다. 자체 고정환율 기준으로 랩콥은 이제 중앙 연구소가 한 자릿수 후반대 성장을 기록할 것으로 예상하며, 초기 개발 부문은 한 자릿수 초반대 성장을 지속할 것으로 전망하고 있다.
회사는 진단과 BLS 부문 모두에서 연간 이익률 확대를 계속 예상하고 있다. 조정 EPS 가이던스 범위의 중간값은 12.5%의 성장을 의미한다. 또한 랩콥은 2026~2029년 장기 전망을 재확인했다.
리스크 및 주시 사항
PAMA에 따른 임시 미국 메디케어·메디케이드 서비스 센터(CMS) 수가표는 2027년부터 수백 가지 연구소 검사에 대한 메디케어 수가 환급을 감소시킬 것으로 예상된다. 랩콥은 2027년 전통적인 메디케어 및 메디케이드로부터 약 1억 2,500만 달러의 영향이 발생하고 다른 민간 보험 계약에도 일부 파급 효과가 있을 것으로 추정하고 있다.
경영진은 Results Act 법안 통과 또는 시행 연기 가능성을 계속 지지하는 한편, PAMA 시행을 기본 시나리오 가정으로 활용하고 있다. 2027년에 가장 큰 영향이 미칠 것으로 예상하며, 2028년과 2029년에는 영향이 의미 있게 감소할 것으로 보고 있다.
진행 중인 인수합병의 시기와 경제성은 규제 당국의 승인, 관례적인 종결 조건 및 통합 진행 상황에 따라 변동될 수 있다. 새로 인수한 사업 부문이 랩콥의 평균 부문 이익률에 도달하는 데에도 시간이 걸릴 수 있다.
오바마케어(ACA) 관련 영향으로 3분기 진단 검사량이 약 30bp 감소했다. 경영진은 4분기에도 비슷한 영향이 있을 것으로 예상하며, 이는 업데이트된 가이던스에 반영되었다고 밝혔다.
애널리스트 Q&A 주요 내용
- 2027년 이익률 및 PAMA: 경영진은 진단 부문의 기저 성장, BLS의 지속적인 모멘텀, 런치패드 생산성 조치의 가속화, 사업 개발 등 4가지 주요 상쇄 요인을 꼽았다. 다만 PAMA가 시행되는 첫해는 이후 연도보다 더 어려울 수 있다고 주의를 당부했다.
- 인수 시너지: 랩콥은 자체 연구소 네트워크, 환자 서비스 센터, 조달 규모의 경제, 보험사 계약 및 기존 영업 인프라를 활용해 인수한 사업 부문을 지속적으로 개선해 나갈 것으로 기대하고 있다. 경영진은 이미 이전 두 건의 바이오리퍼런스 거래를 완료하고 성공적으로 통합했다고 강조했다.
- M&A 파이프라인: 경영진은 병원 파트너십과 지역 연구소 전반에 걸쳐 파이프라인이 견조하다고 설명했다. 또한 PAMA 시행으로 인해 중소형 연구소들이 전략적 선택지를 재검토하게 될 수 있다고 덧붙였다.
- BLS 수요: 중앙 연구소 수주는 대형 제약 고객, 전문 적응증, 그리고 활발해지는 심혈관·대사 분야 활동에 힘입어 견조한 흐름을 보였다. 경영진은 분기별 수주액이 변동될 수는 있으나 기저 수주출하비율 실적은 강세를 유지할 것으로 예상했다.
- 미리어드 제네틱스 거래: 랩콥은 퍼스트진(FirstGene) 단일 유전자 NIPT 제품을 여성 건강 포트폴리오, 고객 관계 및 영업 인프라와 결합할 수 있는 핵심 전략적 자산으로 강조했다.
- PAMA 영향 완화: 2027년에 대비하기 위한 조치가 이미 시작된 가운데 런치패드 이니셔티브가 가속화되고 있다. 또한 랩콥은 비메디케어 계약을 정부 수가표 연동에서 분리하기 위한 노력을 지속하고 있다.
실적발표 콘퍼런스 콜 전문
전체 실적 발표 컨퍼런스 콜 녹취록
경영진 발표
Operator
Good day and thank you for standing by. Welcome to the Q3 2026 Labcorp Holdings Earnings Conference Call. [Operator Instructions] Please be advised that today's conference is being recorded. I would now like to hand the conference over to your first speaker today, Nickolo Russo, VP, Investor Relations. Please go ahead.
Nickolo Russo
Good morning, and welcome to Labcorp's Third Quarter 2026 Financial Results Webcast. With me today are Adam Schechter, our Chairman and Chief Executive Officer; and Julia Wang, our Executive Vice President and Chief Financial Officer. This morning, in the Events section of the Labcorp Investor Relations website at ir.labcorp.com. We posted both our press release and the supplemental financial presentation with additional information on our business and operations. We will also host a replay of this webcast on the IR website for 1 year.
On today's webcast, we will focus on our adjusted non-GAAP results for the third quarter of 2026, our capital allocation strategy and our updated financial guidance for the full year 2026. Our GAAP results and a reconciliation of the non-GAAP financial measures to the most comparable GAAP financial measures are available in today's earnings release and the supplemental financial presentation. Please see the use of adjusted measures section in the supplemental presentation for more information regarding our use of non-GAAP financial measures.
In today's remarks, the term organic growth excludes the impact from acquisitions, divestitures and currency as well as other strategic actions taken in the early development business. Our remarks will also include forward-looking statements, including, but not limited to, statements about our updated 2026 financial guidance and long-term financial outlook and the related assumptions of each. The expected impact of various factors on our business, operating and financial results, cash flows and financial condition, global economic and market conditions, our future business strategies the expected savings, benefits and synergies from acquisitions and other transactions and partnerships and our potential opportunities for future growth. Each of these forward-looking statements are subject to change based upon various factors, many of which are beyond our control. More information is included in our most recent annual report on Form 10-K and subsequent quarterly reports on Forms 10-Q and in the company's other filings with the SEC. We have no obligation to provide any updates to these forward-looking statements even if our expectations change.
Now I'll turn the call over to Labcorp's Chairman and CEO, Adam Schechter. Adam?
Adam Schechter
Thank you, Nickolo. Good morning, everyone. We appreciate you joining us today to review our third quarter 2026 results. Labcorp delivered another strong quarter, with 7% revenue growth driven by volume, margin expansion across the enterprise and 14.5% EPS growth. Our results reflect disciplined execution as we drive continued momentum in diagnostics, and biopharma laboratory services. With these strong results, we are increasing our 2026 guidance.
Before turning to the specifics of the quarter, I want to briefly address PAMA. We are disappointed by the recent announcement on the proposed fee schedule changes related to PAMA, which is expected to reduce Medicare reimbursement rates for hundreds of laboratory tests beginning in 2027. The preliminary fee schedule is not fully representative of the broader commercial laboratory market. The proposed rates rely on data from only 2% of all laboratories paid under Medicare Part B in 2024. And very limited data from physician office laboratories and hospital outreach laboratories. In our view, these payment cuts will threaten patient access to laboratory services. They will negatively impact patient care and innovation, and they will impact the viability of laboratories across the United States.
We previously considered PAMA-related reimbursement pressure in developing our '26 to '29 long-term outlook, and we are reaffirming that outlook today. With a strong underlying business momentum, our strong biopharma laboratory business and the business development opportunities before us, along with our LaunchPad initiatives, we remain very positive about the future. LabCorp continues to support the Results Act a solution with strong bipartisan support that we courage a sustainable and innovative laboratory diagnostic system in the United States.
Now let's turn to our strong financial performance for the third quarter. Revenue grew 7% to $3.8 billion. AOI margin expanded 60 basis points to 15%, adjusted earnings per share grew 14.5% to $4.78, and free cash flow was $412 million. Moving to our segments. Diagnostics revenue increased 6.5% to $2.9 billion. Biopharma Laboratory Services revenue increased 8.5% to $867 million, driven by continued strength in central laboratories. Our BLS book-to-bill was 1.13 in the quarter, and 1.10 in the trailing 12 months. Julia will talk more about our strong results and increased 2026 guidance in just a moment.
At our Investor Day, we laid out the next phase of Labcorp's strategy and the priorities we believe will drive attractive growth over the long term, beginning with leading in specialty testing. As new therapies emerge, particularly in high-growth specialty areas like oncology, neurology, autoimmune disease and women's health. Labcorp's testing solutions are integral for drug development, diagnosis, therapy selection and ongoing disease monitoring. Our specialty testing business continues to grow about 3x faster than the broader diagnostics market. Importantly, this growth creates a halo effect for our core laboratory business. As physicians often order specialty tests alongside other Labcorp tests for their patients, driving volume growth across both specialty and core diagnostic testing.
During the quarter, we expanded our leadership position across important high-growth specialty areas. In oncology, we meaningfully advanced precision medicine. We announced FDA approval of a companion diagnostic, supporting patients with advanced melanoma. This approval supports treatment decisions for both patients and providers and demonstrates the capabilities of our PGDx platform, strengthening our position in companion diagnostics. This platform can support future companion diagnostic opportunities, and we are seeing increased interest from our biopharma clients. We also announced a collaborative clinical study with the Knight Cancer Institute at Oregon Health and Science University, evaluating Labcorp's plasma detect genome, MRD test, to detect muscle invasive bladder cancer reoccurrence, a significant clinical challenge despite advances in treatment.
Moving to neurology. New therapies, blood-based biomarkers and an increasing understanding of neurodegenerative disease, are enabling earlier diagnosis, more for treatment decisions and improve patient care. Labcorp is a leader in this space. And our neurology portfolio spans Alzheimer's disease, Parkinson's disease, ALS, multiple sclerosis, epilepsy stroke and other neurological conditions. Subsequent to the quarter, we launched an FDA-cleared pTau217 test for Alzheimer's disease available in both primary and specialty care settings. This launch will help bring Alzheimer's testing to clinical practices, enabling earlier and more accessible detection. This test will also strengthen our position in one of the fastest-growing areas of specialty testing.
Beyond our specialty focus areas, we continue to leverage science and innovation to address many important health care needs. For example, we launched a hepatitis D reflex test to support earlier detection of the most severe form of viral hepatitis. We announced the collaboration with Waters Corporation, that positions Labcorp as the first commercial laboratory to offer the FDA-approved BD Onclarity HPV assay across clinician and self-collected screening options, including in-clinic patient service center and at-home settings. Focusing now on the priority of being a partner of choice for health systems and leading pharma. Partnerships and acquisitions expand access to testing capabilities and allow us to bring the benefits of scale, science and operational excellence to customers.
During the quarter, we acquired MLM Medical Labs, expanding our global central laboratory capabilities. This acquisition establishes Labcorp as the only central laboratory provider with a wholly owned laboratory network across 4 continents, North America, Europe, Asia and Africa. We also partnered with the National Association of Community Health Centers to strengthen leadership development, support practice improvement and advanced community health initiatives across the nation's community health center network. Subsequent to quarter end, we signed 3 acquisition agreements, each of which is expected to meet our financial criteria of being accretive to adjusted EPS in the first year and returning the cost of capital by year 3. The timing of each of these is subject to regulatory approvals and customary closing conditions. These include an agreement to acquire select assets of bio references health laboratory testing business.
An agreement with Myriad Genetics to acquire their prenatal health testing business, which includes the prequel, Foresight, sneak-peak and first gene tests and an agreement to acquire Millennium Health, an accredited specialty laboratory with 1 of 15 years of experience in drug testing and surveillance. We continue to have a strong pipeline of partnership and acquisition opportunities that support our long-term growth strategy. We look forward to discussing it with you in the future. Moving to personalized health solutions, which encompasses both precision medicine and consumer health. In addition to several new companion diagnostics, we also launched solutions that help consumers better understand, manage and improve their health.
In the quarter, Labcorp On-Demand launched our Advanced Health panel and the Marker by Labcorp Genetic Health Panel. With our 140 panels and tests across many conditions, we provide insights to consumers to understand their health over time. We also announced a collaboration with Thrive Global to launch the Thrive 5 Health Test on Labcorp's On-Demand. A test that combines lab results with other health biomarkers to help improve cardio metabolic health. In addition to the results, consumers receive personalized educational content and a practical action plan. These examples demonstrate the value of Labcorp's lab testing capabilities to deliver more meaningful insights for consumers.
Shaping our future through technology and innovation continues to be a focus of our organization. Our advanced technology solutions include the My Labcorp app, test finder and increased automation in our laboratories using robotics, digital pathology solutions to improve customer experiences to enhance productivity and to help transform our business. In the quarter, our central laboratory service business launched the next generation of Labcorp's Global Trial Connect, helping pharmaceutical sponsors and investigator sites more effectively navigate growing clinical trial complexity, reinforcing our commitment to delivering differentiated technology-enabled solutions for our customers. The strength of our technology strategy and continued focus on innovation was recognized by Forbes, which named Labcorp to its list of America's best employers for tech workers.
With that, I'll hand it over to Julia to discuss our financials in more detail.
Julia Wang
Thank you, Adam. Our third quarter results represented strong execution and continued progress against our strategic priorities. Enterprise revenue grew 6.9% versus prior year. Adjusted operating margin expanded 60 basis points, primarily driven by organic revenue growth and operating efficiencies. Adjusted earnings per share grew 14.5%, and we generated $412 million in free cash flow. These results demonstrated the earnings leverage in our business as solid organic growth disciplined execution and productivity improvement translated into margin expansion and double-digit earnings growth. We remain active in cargo deployment with $256 million in acquisition and $58 million in dividends. We ended the quarter with $262 million in cash and $5.9 billion in total debt. As approved by our Board of Directors, we currently have approximately $1.4 billion remaining in our share repurchase program, providing continued flexibility to return capital to shareholders.
Moving to more details on the quarter. Enterprise revenue was $3.8 million, up 6.9% from the third quarter of 2025. Organic revenue growth was 5.5%. Net acquisitions contributed 1.5% of growth, partially offset by foreign currency translation of 0.1%. Adjusted operating income was $570 million or 15% of revenue compared to $513 million or 14.4% of revenue last year. The adjusted tax rate was 22.9%, in line with last year. We continue to expect our full year adjusted tax rate to be nearly 23%. Adjusted EPS was $4.78, up 14.5% from last year. Free cash flow was $412 million compared to $281 million last year. The increase was primarily driven by the improvement in working capital, partially offset by planned increases in capital expenditures. Our strong cash generation provides continued flexibility to invest in the businesses while maintaining a disciplined approach to capital deployment.
Turning to our segments. Diagnostic laboratories continued to perform well. Revenue was $2.9 billion, up 6.5% compared to the prior year. We delivered organic revenue growth of 4.4%, consisting of 3.1% volume growth and 1.3% favorable price/mix, largely driven by higher tax per accession. Acquisitions contributed 2.2% to revenue growth. Diagnostics adjusted operating income was $492 million or 16.7% of segment revenue compared to $450 million or 16.3% of revenue last year. The combination of healthy organic growth and continued operating efficiencies drove 40 basis points of margin expansion in an diagnostics.
As Adam mentioned, subsequent to the quarter end, we entered into agreements to acquire select assets of BioReference Health, Myriad Genetics Prenatal health testing business and the Millennium Health, in addition to being a strong strategic fit, each of these transactions is expected to meet our acquisition financial criteria of being accretive to adjusted EPS in year 1 and returning cost of capital by year 3. As typical with all of our acquisitions, we expect this transaction to become more accretive over time as we fully integrate. Related to the BioReference cost transaction, we would expect to generate $250 million of revenue in the first 12 months. At adjusted operating margin slightly higher than the Diagnostics segment average, resulting in approximately $0.15 of adjusted EPS, including financing costs.
We currently expect a midyear 2027 growth. subject to regulatory approvals and customary closing conditions. As it relates to the Myriad Genetics transaction, we expect to add approximately $160 million in revenue and to be slightly accretive to adjusted EPS in year 1 and to reach average diagnostics segment margins by end of year 2 was fully integrated. We currently expect an early 2027 close, subject to regulatory approvals and customary closing conditions. BLS revenue was $867 million, up 8.5% compared to last year. Organic constant currency revenue growth was 9.6%. The strong organic growth was partially offset by the strategic actions in early development of 1.2%, and acquisitions offset the impact of foreign currency translation. Within the BLS segment, on an organic constant currency basis.
Central Labs Services delivered strong revenue growth of 11.3% and early development grew 5%. The strong growth in Central Line was essentially driven by a healthy underlying demand. while favorable timing related to study stores in the quarter also contributed. BLS segment adjusted operating income was $159 million, or 18.3% of revenue compared to $132 million or 16.5% of revenue last year. Adjusted operating margin expanded 180 basis points, driven by organic growth and operating efficiencies from the strategic actions we have taken in early development. Our BLS segment end date to the quarter with a backlog of $8.9 billion. We expect approximately $2.8 billion to convert into revenue over the next 12 months. Quarterly book-to-bill was strong at 1.13, translating into a strong trailing 12-month book to bill of 1.1. The combination of robust organic growth, significant margin expansion and healthy book-to-bill reinforces our confidence in the trajectory of BLS.
Turning to our full year 2026 guidance. Strong year-to-date execution and continued business momentum give us increased confidence in our outlook. As a result, we are raising the midpoint of our 2026 enterprise revenue range and adjusted EPS range by $65 million and $0.18, respectively. The increase in our outlook reflects a strong branding business performance, partially constrained by approximately $10 million in incremental foreign currency headwinds versus our prior guidance. Enterprise revenue is expected to grow 5.9% to 6.7%, which represents a 50 basis point increase at the midpoint. The guidance includes a 30 basis point benefit from foreign currency translation versus a 40 basis point benefit in our prior guidance. Diagnostics segment revenue is expected to grow 5.5% to 6.2%. This is a 20 basis point increase at the midpoint. We continue to expect the majority of the growth to be driven by organic performance.
BLS segment revenue is expected to grow 7.4% to 8.4%. We have raised the midpoint of our BLS revenue guidance by 190 basis points, primarily driven by continued strength in Central Labs. The current guidance includes a 130 basis point foreign currency tailwind compared with a 150 basis point tailwind in our prior guidance. For the full year, on an organic cost and currency basis, we now expect Central Labs revenue to grow in the high single digits and continue to expect early development to grow in the low single digits. We continue to anticipate enterprise margin expansion for full year 2026, driven by both diagnostics and BLS relative to 2025. At the enterprise level, LaunchPad continues to deliver productivity improvement and remains on track for the $125 million full year savings target. Our adjusted EPS guidance range is $18.30 to $18.70, with an implied growth rate at the midpoint of 12.5%.
Our free cash flow guidance range remains $1.24 billion to $1.36 billion. We continue to expect capital expenditures to be nearly 4% of revenue. Our full year guidance assumes foreign exchange rates as of September 30, 2026. The guidance also reflects our current capital allocation assumptions, including the use of free cash flow for acquisitions, share repurchases and dividends. As we look towards 2027 based on the preliminary fee schedule proposed by CMS, we estimate the impact of PAMA to be approximately $125 million, and we expect to offset a portion of that impact. With our underlying business momentum in diagnostics, strong biopharma business, versus development opportunities and large plan initiatives. We remain very positive about the prospects of 2027, and we look forward to providing 2027 guidance in February.
Now I will turn the call back to Adam for closing remarks.
Adam Schechter
Thank you, Julia. Let me close with a few takeaways. First, we delivered another excellent quarter with strong revenue growth, margin expansion and double-digit adjusted EPS growth. Second, we are translating the strategy we laid out at Investor Day into execution, strengthening our leadership in specialty testing, expanding strategic partnerships and acquisitions, accelerating personalized health solutions and leveraging technology to improve performance. And third, as a result of our performance, we are increasing the midpoint of our full year guidance for revenue and EPS and expect to move into 2027 with solid momentum. We are confident in our strategy. We're encouraged by the opportunities ahead of us, and we are well positioned for continued strong performance moving forward.
Operator, we will now take questions.
Operator
[Operator Instructions] Our first question comes from Erin Wright of Morgan Stanley.
질의응답
Erin Wilson Wright
So I have a question about margins and margin progression into next year and kind of where things land. Just given in the context of PAMA in the 75 to 150 basis points of margin expansion over 3 years that you laid out at the Investor Day, and also looping in sort of the acquisitions that you recently announced, how do you think about that margin cadence, particularly in 2027? Can you expand margins next year? And what are some of those moving pieces on that front if PAMA is implemented and obviously, those deals close?
Adam Schechter
Yes. Thank you, Erin, for the question. And the good news is we have a lot to talk about here. We have continued strong momentum in our business. If you look at our Diagnostics business and you look at margins, we've increased our margins for many quarters in a row now. And we expect, if you put PAMA aside that we will continue to improve those margins as we move into the future. Obviously, we'll wait to see what happens to the PAMA and the results tax. Obviously, the year that PAMA is introduced, will do as much as we can to offset PAMA. I think we have 4 strong levers to do that. the underlying diagnostic business, the strength in our biopharma laboratory business, the Launchpad initiatives that we'll continue to push really hard, particularly in a PAMA year and also the business development opportunities that we've announced, and we have others before us. So all those things will help offset the impact of PAMA. But obviously, the year that PAMA is implemented will be a tougher year than the other years. It will get easier after the PAMA years.
It also depends on the timing of the business development. And when we close those deals. We expect each one of them to be accretive in the first year, so they should be helpful in terms of accretion, but it takes a bit of time before the margins get to our average margins. For example, the Myriad deal, which is a great deal would not have margins reach our average margins until the end of year 2. So it would take a little bit of time for the margins to get there, and it really depends on the exact timing of those deals. For example, for the Myriad deal, we expect it to happen in early 2027. So we'll provide exact guidance in February of next year. But what I'll say is we are confident that we're moving into 2027 with momentum. We reaffirmed our guidance today even after giving what we expect PAMA to be in year 1. So it tells you that we're confident in the margin expansion over time.
Julia Wang
Erin, maybe to add a bit more color. As it relates to margin, we're very pleased with the progression we have made as an enterprise. Actually, Q3 represented the sixth consecutive quarter of margin progression across the enterprise, inclusive of the 2 operating segments. The other fact I would share is that when you step back, look at the fundamental drivers of our margin expansion, it really bodes down to strong organic growth for both operating segments particularly in the leading diagnostic and CLS business is our relentless focus on operating efficiencies through our launch plan initiatives. And of course, this year, we also benefited from the strategic actions that we have taken in early development. And as Adam also shared just now, when you look at 2027, we really have multiple levers that we can really pull weather through the continued strength in diagnostics or continue the momentum in BLS. But the business development will be another lever in addition to our focus on launch plan, which we will be leveraging advanced technologies to help us fundamentally driving the cost out of the system in a sustainable way of working. So all in all, we are looking forward to wrapping up 2026 with really strength going into 2027 with momentum, so stand with more guidance coming in February of 2027.
Operator
Our next question comes from Lisa Gill of JPMorgan.
Lisa Gill
I want to follow up on those comments on the business development side. Adam, you've done 4 deals here in the last couple of weeks. Can you maybe just talk about what you're seeing currently in the pipeline, number one; two, we've had some questions from investors about the margin progression for some of these acquisitions because inside of some of the current companies, they're not accretive. So can you maybe help people to understand is it that you just convert that to the contracts you have with managed care, and that's why you have the visibility around how the margin profile will look for the business development? And then just lastly, anything else you would want to share as we think about an M&A pipeline as we go into '27. Is it increasing? Do you see incremental opportunities? Just how do we think about business building?
Adam Schechter
Sure. Thank you, Lisa. So first of all, the pipeline remains strong. And it's interesting. I've been talking about the strong pipeline for some time now and several people sit out and we keep talking about it, one of these deals going to happen. I think this just shows you can't control the exact timing of deals. But when the pipeline is strong, the deals will come. We have other deals in the pipeline. I'm excited about that pipeline. We expect to have more announcements and the future as we move forward, the pipeline remains strong. The interesting thing about PAMA, where, on the one hand, it has a significant impact to us in 1 year. I think it also increases the pipeline for business development. I think smaller hospital laboratories, regional, local laboratories, they're going to struggle a lot with PAMA, and it really does cause them to rethink about their business.
The second question regarding the individual deals and margin expansion. I would say each of these deals are a little bit different. MLM is a deal that was for our central laboratory business, it expands our capabilities. It gives us a presence in a part of the world where clinical development is very strong. And it's a very separate part of our business that's integrating that deal. If you look at the other 3 deals, we'll start with the Myriad deal, which I think is a very good deal for us because it's in women's health. It's an area we know well. It brings new tests to us. The FirstGene, the Prequel, the Foresight, the SneakPeak, they're all good women's health products that we can add to our existing portfolio of products. And we already have sales forces. I think that together we can reach more patients, we can improve access. We can bring new tests that we don't currently have to the patients that need those tests in the physicians that want those tests. So it will actually be a very competitive environment of which we can now compete much more effectively with these tests than before. It will be accretive in the first year. It follows nicely to a business we know how to run. We've done deals with Myriad before, so we know how to work with them and how to integrate. So it's an exciting opportunity for us.
If you look at the Millennium deal, that's a part of our business that's a separate business unit. We do very well in that business. But this increases our presence in parts of the country that we don't have a presence in or we don't have a strong presence right now. So it's a business we know how to run. It's a business we've been involved in for many years, and it just expands our geographic footprint and enables us to be more competitive, improve access to a part of the country that we don't have as much access as of today. And if you look at the BioReference deal, we've done 2 deals with them already. We know how to work with them very well. We've worked with them on integration, so we know how to integrate with them very well. They have a presence at the country that we're not as strong. And so, it increases our relevance in parts of the country where we want to increase our presence, increases access, and we know how to work with them to integrate the business well into our existing business. So the timing, we tried to give you a sense of what those timings were Myriad, early 2027, while referenced mid-2027, Millennium later this year. And then based upon the timing, we would expect that margins would be accretive to earnings in the first year, margins improve over time.
Operator
Our next question comes from Ann Hynes with Mizuho.
Ann Hynes
Staying on that women's health topic. I know we've seen some meaningful changes in cardiovascular screening recommendations from the AHA and the American College of Cardiology I think in March, they expanded testing for certain patients. But yesterday, they really expanded recommendations from Women's cardiovascular health. When major organizations like this do change the recommendations? How should we think about the potential impact for you? Do physicians typically change their ordering patterns quickly? Is there like a lag time and adoption time and just from an insurance perspective, if some of these tests are uncovered, do they usually start covering them because of these organizations, recommendations?
Adam Schechter
Yes. No, thank you, Ann. I think women's cardiovascular health has been something that I personally focused on for a long time, and I'm glad to see that it's now being focused on by these are this societies and so forth. It's an underdiagnosed disease, particularly in women. It goes undiagnosed in a way in which it presents itself cardiovascular disease. And I think there's a lot more that we can do to enhance the health of cardiovascular health of women. So it's nice to see that the societies will move in that direction. I would say many physicians have already moved in that direction. I've already begun to screen women for cardiovascular. They teach women how cardiovascular disease prevents very differently at times in women versus men. And I think that we've seen a movement to actually improve cardiovascular health and women already.
Separate and distinct from that, when societies provide recommendations, I do think it's a way for us to reinforce with payers the importance of paying for those tests. I do believe that physicians will tend to prescribe more of those tests faster when they become a core recommendation of a very strong society. or group of highly thought of physicians and thought leaders. So I do think it's helpful, although when you do 750 million tests per year, it's hard to kind of pull out any type of change like this I do think that it's for benefit of women. I do think it will help us over time.
Operator
And our next question comes from Eric Coldwell of Baird.
Eric Coldwell
Congrats on really nice results and outlook. I'm probably going to deliver my worst question of the quarter here because there's a lot -- so we actually like your deals. You've been very clear about the capital deployment, but I have been particularly concerned about the BioReference, the BRL deal because we do have their financials, we know the revenue that you expect. I think we have a reasonable estimate on cost of capital, et cetera, et cetera. And it was very hard for me to initially come up with year 1 accretion on that deal, particularly when the first quarters are typically well below what your exit rate is post synergy. So help me figure out what I'm missing here. is there like a tax benefit driving that $0.15 of accretion because at face value, rough scratch pad on the math, it looks like you're actually guiding to a year 1 operating margin of something like 22% or 23% to get to $0.15 of accretion. And I'm just -- tell me what I'm missing on this because that's, quite frankly, a lot better than I expected.
Adam Schechter
Yes. So once again, BRL is a company that we've worked with. We've done 2 deals with. So we understand their systems, we understand their cost structure. We understand the way in which they do business very well. And when we looked at the business there in geographies where we think we can increase access, we can bring our kind of testing capabilities more broadly. And there are in areas, frankly, we're not as strong and where they were strong. Overall, when we gave the revenue estimate, we've included the impact from PAMA. That could be in there. We've included some other things in terms of where the revenue we expect to be in the year versus what they might have reported before. We also have a very good handle on what their cost structure is and what that would look like in our hands versus in their hands. I don't know, Julia, if there's anything you would add to that.
Julia Wang
Yes. I think, Adam...
Eric Coldwell
Just Julia, I appreciate any comments you make. I guess I just want to -- I think, if I remember, they have something like 80 service centers. Are you planning to just do like big consolidations here drive all of their volume to your lab in the area. I'm just -- anything you could help us with on the synergy path and the cost path would be helpful to stage the concerns that at least I had.
Adam Schechter
So over time, when it comes to the service centers, where there's overlap, we'll decide which service center is best to keep. So it could be that we closed down some Labcorp service centers could believe that we closed down somewhere else. But where there is overlap, we would look, obviously, to have synergies. We also will be able to look at the capacity in their laboratory, the capacity we have in our Raritan laboratory, both of which are close to each other. And where we were going to expand because of our business development growth opportunities, we might not have to expand in areas that we had before or we'll look to say other synergies there as well. So it could be a reduction of the expansion that we were planning based upon the number of deals that we've done this part of the country. So I think that you'll find synergies across the business, Eric. But in addition to that, I just believe when you look at contracting and stuff like that, there's always things that are helpful.
Julia Wang
Yes. I believe Adam has covered the ground. I think the only thing I would say is that, as Adam already said, because we have had this long-term partnership with BioReference with 2 prior acquisitions already having been successfully integrated and demonstrated our ability to really deliver against our expectation as it relates to return on investment. So we are feeling very comfortable with the outlook that we put out there as it relates to the first year contribution. And actually, if you look at the few transactions was just announced subsequent to the quarter end, they are all tucking in nature, whereby we have a very proven track record of successfully integrating them into our extensive operating scale and infrastructure and then being able to really drive synergistic value through both growing the top line and also optimizing the cost structure. So we look forward to updating you as we continue to make progress, but we're confident ability to really continue to drive acquisitions to contribute 1.5% to 2.5% revenue growth for our overall growth trajectory, but also continue to drive more operation over time as we fully integrate those transactions.
Adam Schechter
And the last thing I would say, Eric, is when you look at our procurement capabilities, you look at our cost based upon the scale of what we do, all of that comes into play and is helpful as well.
Operator
Our next question comes from Michael Cherny of Leerink Partners.
Michael Cherny
One just quick housekeeping and then one additional question. First, just on the change in revenue guidance. Can you just remind us how much is from M&A in terms of what's built into the update for the year? And then relative to PAMA, Adam, I think we all hear you completely on your view on the Results Act and the logic behind it. That being said, it is a tough environment in D.C. Can you just give us a flavor as you think about the offsets for '27, what the organization is starting to do now to prepare for that?
Julia Wang
Michael, let me start addressing the question as it relates to the guidance you raised I would say that the risk is driven by strength in the organic performance of our businesses. So if I break it down segment by segment, starting with an ad, we raised the midpoint of our guidance by 190 basis points, $59 million on an absolute basis. And in addition to strength in organic performance, particularly in SMS. We also shared in the release that we have about 10 basis points of FX headwind when you look at this guidance versus prior guidance and that the FX impact was actually offset by expected contribution from the MLM acquisition that we closed in September. And then if you were to move to the Diagnostics segment, we raised the midpoint of our guidance by 20 basis points and $22 million on an absolute basis I would say there's a little bit expectation about potential revenue contribution from the Millennium Health acquisition, which we expect to close later in this year, but it's very minimal in the scheme of things, I would really consider that as immaterial. In short, we are reaching the midpoint of our guidance for the full year from a revenue perspective by 50 basis points, $65 million. And if you neutralize FX, it would be a rise of 60 basis points and $75 million, all driven by strength in the organic performance of our businesses.
Adam Schechter
And then regarding PAMA, obviously, we remain disappointed by the recent announcement. But in our base case, we're going to assume that PAMA happens next year. That is a $125 million impact from the traditional Medicaid, Medicare segment. We're still cautiously optimistic about results. We'll still continue to fight for that. We'll fight for delay if results doesn't get past this year. But in our base case, we want to assume that it does happen next year. So if you look at the 4 things that we're doing to offset it, one is the underlying diagnostic business is strong, and we will continue to focus on it. The volume looks good. Our strength is there. So the underlying business, we expect to remain strong. The second thing is our BLS business continues to remain strong, and we're going to continue to focus on that to grow that business. The book-to-bill looks great. So that's another way to offset part of it. .
Our LaunchPad initiatives, we're accelerating. And we're already focused on that. We have things underway that we're putting in place in fourth quarter to prepare for first quarter, we'll give you the exact amount. But you saw at Investor Day, we raised our expectation of what we expect for LaunchPad from prior guidance. So it's meaningfully higher now than it has been in the past, and we're accelerating our efforts as we speak today. And then the fourth thing is the business development, which you've seen us announce for business development, things in the past month or so, and there's more to come. We're continuing to have a very strong pipeline. There's a lot we can do there. You can't accelerate those per se, but we continue to focus on those other opportunities, and I would expect that there's more to come in the not-too-distant future
Operator
Our next question comes from Luke Sergott at Barclays.
Luke Sergott
I just want to talk on the biopharma services and the demand that you guys are seeing. You had really strong pickup there in bookings. I understand it was a little bit easier comp, really nice acceleration there. And so your conversion is also kind of picking up as well. Can you just walk through the dynamics where you're seeing the demand? Is it like any particular indication or therapy and just give us an overlay of how that visibility into that continuing through the beginning of next year?
Adam Schechter
Yes. So if you look at the central laboratory business, in particular, had very strong growth. And in the quarter, the growth was driven by healthy underlying demand. We also had some favorable timing related to study starts in the quarter, but it's mostly the underlying demand. As you look to the book-to-bill, as you said, it is strong. And I would say that it's strong in both our central laboratory business, but also in our early development business. In our central laboratory business, it's driven by large pharma. And it's driven by not only oncology and specialty areas where we've seen growth in the past, but we are seeing an increase in cardiometabolic areas. And when you look at the GLP-1s and a number of different trials and types of trials, we are seeing some accelerated opportunities in that area as well. .
When it comes to early development, we're seeing that the funding environment looks pretty good. It's driven by smaller biotechnology companies, but we are trying to change that a bit by getting more large pharma business in that area. And we are beginning to see some early signs of success in doing that. So in summary, both businesses are doing well. The business is driven by central laboratories. Central Laboratories book-to-bill looks really strong. Specialty areas, particularly oncology, continues to grow, but we're seeing more growth in areas like cardiometabolic.
Luke Sergott
Great. And then a follow-up on that. I mean, as you look, demand continues to pick up. Can you talk about what you're seeing from a capacity expansion in the industry? And if that's -- how tight is that getting? And then obviously, it would bode well from a pricing perspective as we think about the out years?
Adam Schechter
Yes. So as I look at our capacity, we continue to have plenty of capacity. So we have a very large footprint. We have Central Laboratories now in 4 continents of wholly-owned subsidiaries, but we also have access to other parts of the world, and we're increasing our access in other parts of the world like, for example, in Latin America. So our geographic presence, our ability to have these large laboratories gives us capacity for even more growth as we go into the future. So I'm not concerned about our ability to take on new business. In fact, we're looking for as much new business as we can get moving forward.
Julia Wang
And look, earlier, we shared that we are in the process of building a state-of-the-art lab facility in Indianapolis. Actually, that is in response of anticipated continued momentum growth, particularly for the CLF business. So we're in the middle of that engagement right now, and that is reflected in our capital expenditure for this year and the next couple of years.
Operator
And our next question comes from Tycho Peterson of Jefferies.
Tycho Peterson
I want to follow up on the Myriad deal. You are buying the assets after the management team talked about a 60% revenue decline, share loss and payer friction, and that was all before the CLF rate proposal, which is an additional drag on revenue. So why is now the right time to do that deal? And why are you the right partner to turn around that business?
Adam Schechter
Yes. No, great question, Tycho. We feel very comfortable and confident in taking over that business. In fact, it's a very strong business for us today, but they have, in particular, the FirstGene test, which we think has tremendous opportunity. So it's newly launched. It's an innovative single gene NIPT solution. It screens for chromosomal conditions, select single-gene disorders, maternal carrier status and R&C compatibility. So it's going to compete really well in the fastest-growing part of the segment where we don't necessarily compete today. So taking our strong existing tests and infrastructure and relationship with customers and our scale. Now combining it, in particular, with this new test, which will compete in a very competitive part of the market, I think, bodes well for us to be the right group to launch that and also the right time to launch it because that market is still being defined, and we think we could be a winner ultimately.
Tycho Peterson
Okay. That's helpful. And then one quick follow-up on BLS. I appreciate all the momentum and strength you're seeing, especially on the pharma side. I guess as we think about biotech funding getting a little softer here, how do you think about the impact there on early development?
Adam Schechter
Yes. So again, the early development business, much smaller, much less important part of our business, but it is performing well right now. We've made some good strategic moves. We're seeing our RFP is strong there. The study starts are strong there. We're trying to kind of switch more of our load to larger pharma, and we're seeing some early signs of success. So I feel good about where we are today.
Operator
Our next question comes from David Westenberg of Piper Sandler.
David Westenberg
So I'm going to ask a question about PAMA, I prepared for a bunch of questions on Myriad and first and all that, but it seems to be a lot of acquisition. So I'm going to pivot to PAMA, sorry if the question is bad because I was preparing for something else. But I want to talk about PAMA from kind of a multiyear perspective. We know the worst part is obviously in year 1, which is the 2027, though it does look like a number of tests above that 15%, which kind of suggests there could be some headwinds into '28 and '29. Can you talk about the strategies both from a Labcorp perspective? And kind of how you anticipate industry might change and the way they're thinking about contracting or discipline or any other approach that the industry and at Labcorp again is going to take to maybe think about if indeed PAMA the law of the land, how just the industry might evolve and you evolve in terms of discipline and all that other kind of thing?
Adam Schechter
Yes. No, thank you for the question. And the majority of the impact is in 2027, the first year. And again, assumes that PAMA actually happens, which is our base case, but we're still cautiously optimistic about results and/or delay. There are incremental impacts in '28 and '29, but they are meaningfully less than what '27 would be. And I believe they're manageable and they're within what we should be able to manage in our kind of ongoing running of the business. As I think about over time, we continue to decouple other parts of our contract from referring to the fees drill, and we'll continue to do that. But I feel like 2027 will be the biggest impact, and we can manage through the outer years.
Operator
And our next question comes from Lu Li of Bank of America.
Lu Li
I guess maybe a question back to kind of like the organic growth and then the price mix in the quarter. The volume growth is very, very healthy. The price seems to be slightly lower versus 2Q. I wonder if you can talk about kind of like the growth driver within the volume? And then maybe just anything to call out on the price mix.
Adam Schechter
Yes. So if you look at the diagnostics business, it was very strong. We had 6.5% growth over last year. The organic growth was 4.4%. It was 2.2% that came from acquisitions. If you look at the organic growth, 3.1% was organic volume growth, which was very strong, and that's what we would like to see. Organic price/mix growth was 1.3% and it's driven by what we wanted to be driven by, which is an increase in test per accession and we expect test per accession to continue to increase as we go over time. If you look at any 1 quarter, I wouldn't look at any trend. You are going to see fluctuations between organic volume and organic price mix quarter-over-quarter. But over time, we expect them both to be strong.
Julia Wang
Yes. And maybe a little bit more considerations. If you look at esoteric revenue as a percentage of our total diagnostic revenue, it was about 38% in the first quarter of 2024, and in the third quarter of this year, it went up to 42%. So clearly, you can see the strength of our strategy and execution. And then when you look at the full year guidance for diagnostics, at the midpoint, the revenue growth was 5.9%, and we continue to expect the majority to be coming from organic performance. And within that, we expect the volume growth to slightly outpace price mix variability.
Operator
And our next question comes from Kevin Caliendo of UBS.
Kevin Caliendo
Really happy about all the color on the deals that you had. It was just interesting to me that there really hasn't been a traditional hospital deal announced. I'm just wondering if this is more your own preference around what's happening in the marketplace and where the opportunity lies? Or is it just the availability of assets that are out there? Or is it just simply people are waiting on PAMA and want to know what the rules are going to be and what the economics look like?
Adam Schechter
Stay tuned. Again, you can't control the timing of deals. The pipeline looks strong. The pipeline looks strong for hospital deals, partnerships, local regional laboratories they're just timing things. So I would say that the deal pipeline continues to be strong. I do think PAMA comes it could get even stronger, but stay tuned and there's a lot that we're working on. It's a strong pipeline.
Operator
Our next question comes from Elizabeth Anderson of Evercore ISI.
Elizabeth Anderson
What -- I took maybe a 2-parter. Just any updates on your assumptions around the ACA impact on the business? And then two, any reasons why we wouldn't like continue to see the traditional 4Q seasonal step-up in BLS given some of the things you highlighted in one of the earlier questions?
Julia Wang
Elizabeth. In terms of the ACA impact, it was a slight headwind of about 30 basis points of diagnostic volume in the third quarter which was essentially in line with the second quarter, and we continue to expect a similar level of impact in the fourth quarter. Of course, we've already incorporated this into the updated guidance that we just provided this morning. It's also important to note that this particular insured population account for a very small percentage of our overall diagnostic volume is less than 4% to 5% overall speaking.
And then in terms of the cadence for the BLS business, I would say that if you look at the release, we just shared this morning, we have raised the midpoint of our guidance to the degree that at this moment, we expect on an organic currency basis, the SLS business to grow high single digits. And then the ED business to continue to grow in low single digits. So based on the strength of the momentum, we feel good about that guidance, and we look forward to continuing to march forward to deliver against that expectations.
Elizabeth Anderson
Yes, that make sense. And that would continue in bookings, too, I'm sorry if my question was unclear.
Adam Schechter
Again, we expect continued strength in bookings, but quarter-over-quarter, it does vary quite a bit. Sometimes things get moved into quarter on things get moved out of the quarter. And especially with pharma at the end of fourth quarter, you never know what pharma will be thinking. So the underlying book bill, we expect to remain very strong.
Operator
Our next question comes from Jack Meehan of Operon Research.
Jack Meehan
Adam, I was wondering just on the topic of PAMA. Can you remind me the actions that you've taken to disconnect the non-Medicare business from the fee schedule. And I just wanted to confirm the $125 million estimate. Does that assume any bleed through to other payers? How are you handling that?
Adam Schechter
Yes. No, thank you, Jack. So the $125 million is the traditional Medicare Medicaid. We've done a lot to try to decouple that over time. And we're going to continue to work on that. But the additional impact to me are things that you just manage within your day-to-day business, and that's what we would expect to do. and you always have some pushes and pulls that you work on. So the $125 million is the traditional Medicare Medicaid. There is some spillover into other parts of the business. We're going to manage that as we would manage other parts of our business.
Jack Meehan
Excellent. If I can squeeze in one more. Any updates on your progress towards launching the MRD test. And have you chosen which sequence you're planning to launch that on?
Adam Schechter
So we are continuing to make progress on the MRD test. In fact, we just announced the collaboration with Knight Cancer Institute of Oregon Health System. And that was a clinical study that's evaluating plasma detect genome, MRD Ultra, and it's really looking at reoccurrence for patients with muscle invasive bladder cancer. So we're continuing to look across the portfolio of MRD opportunities. This is just another example of us building data in order to support reimbursement over time. I remain very excited about our portfolio of products. And to my knowledge, I don't believe we've finalized working with any one machine yet at this point in time.
Operator
This concludes our question-and-answer session and also today's conference call. Thank you for participating, and you may now disconnect.
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