U.S. STOCKS ON THE MOVE -Adobe, Salesforce, Stryker

March 26 (Reuters) - Wall Street's main indexes dropped on Thursday following gains in the previous session, as conflicting signals from the U.S. and Iran on the prospects of a de-escalation in the Middle East kept investors on edge. .N

At 13:31 EDT, the Dow Jones Industrial Average .DJI was down 0.87% at 46,027.06. The S&P 500 .SPX was down 1.23% at 6,510.95, and the Nasdaq Composite .IXIC was down 1.67% at 21,564.34.

The top three S&P 500 .PG.INX percentage gainers:

Brown-Forman Corp BFb.N, up 16.4%

Valero Energy Corp VLO.N, up 5.5%

Best Buy Co Inc BBY.N, up 5.0%

The top three S&P 500 .PL.INX percentage losers:

Sandisk Corp SNDK.OQ, down 9.5%

Lumentum Holdings Inc LITE.OQ, down 9.4%

Applovin Corp APP.OQ, down 9.2%

The top two NYSE .PG.N percentage gainers:

Brown-Forman Corp BFb.N, up 16.4%

GrafTech International Ltd EAF.N, up 11.4%

The top three NYSE .PL.N percentage losers:

X Financial XYF.N, down 23.6%

Worthington Steel Inc WS.N, down 15.7%

Snap Inc SNAP.N, down 12.8%

The top three Nasdaq .PG.O percentage gainers:

EpicQuest Education Group International Ltd EEIQ.OQ, up 203.5%

VisionSys AI Inc VSA.OQ, up 100.0%

Kodiak Sciences Inc KOD.OQ, up 73.3%

The top three Nasdaq .PL.O percentage losers:

Megan Holdings Ltd MGN.OQ, down 92.7%

Cambium Networks Corp CMBM.OQ, down 77.8%

WAVE Life Sciences Ltd WVE.OQ, down 48.7%

Olaplex Holdings Inc OLPX.O:
BUZZ - Jumps on Henkel's $1.4 billion buyout nL6N40E0WG

Newmont Corp NEM.N:

Harmony Gold Mining Co Ltd HMY.N:

Gold Fields Ltd GFI.N:

Sibanye Stillwater Ltd SBSW.N:

BUZZ - Gold miners track bullion lower on Middle East uncertainty nL4N40E0JN

Jefferies Financial Group Inc JEF.N:
BUZZ - Falls after quarterly profit misses estimates nL6N40E08G

Robinhood Markets Inc HOOD.O:
BUZZ - Jefferies initiates Robinhood with 'buy' rating, sees leverage in revenue diversification nL4N40E0QF

Navan Inc NAVN.O:
BUZZ - Surges after upbeat 2027 revenue forecast nL4N40E0QS

Corebridge Financial Inc CRBG.N:
BUZZ - Gains after announcing $22 billion all‑stock merger with Equitable nL4N40E0RI

Designer Brands Inc DBI.N:
BUZZ - Falls after posting Q4 loss nL4N40E0SS

Qualcomm Inc QCOM.O:
BUZZ - Falls; Bernstein cuts to 'market perform' nL6N40E0OI

Commercial Metals Co CMC.N:
BUZZ - Slips after Q2 profit miss nL6N40E0Q9

ASML Holding NV ASML.O:
BUZZ - Google's new compression algorithm puts extra pressure on European chipmakers nL8N40E0YA

Lovesac Co LOVE.O:
BUZZ - Rises after Q4 sales beat nL6N40E0QW

Cibus Inc CBUS.O:
BUZZ - Sinks on heavily discounted share sale nL6N40E0QP

Hub Group Inc HUBG.O:
BUZZ - Wells Fargo cuts Hub Group to 'equal weight'; Nasdaq flags late filing nL4N40E0VB

Hecla Mining Co HL.N:

Coeur Mining Inc CDE.N:

Endeavour Silver Corp EXK.N:

Silvercorp Metals Inc SVM.N:

BUZZ - Silver miners fall as metal prices drop nL4N40E0VV

Kodiak Sciences Inc KOD.O:
BUZZ - Jumps after eye drug meets main goal in late-stage study nL4N40E168

Rio Tinto PLC RIO.N:

BHP Group Ltd BHP.N:

Southern Copper Corp SCCO.N:

Freeport-McMoRan Inc FCX.N:

BUZZ - Copper miners fall on high inventories, macroeconomic headwinds nL4N40E0WB

Wave Life Sciences Ltd WVE.O:
BUZZ - Plunges after co reports early-stage obesity drug data nL4N40E120

United Natural Foods Inc UNFI.N:
BUZZ - Climbs after Wells Fargo upgrades to 'overweight'; hikes PT nL6N40E0SM

Firefly Neuroscience Inc AIFF.O:
BUZZ - Jumps on U.S. military health partnership nL4N4010V3

Generac Holdings Inc GNRC.N:
BUZZ - BofA lowers Generac Holdings PT; shares fall nL4N40E0XG

MillerKnoll Inc MLKN.O:
BUZZ - Plunges as Middle East conflict to dent shipments, boost logistics costs nL6N40E0T1

Alphabet Inc GOOGL.O:

Meta Platforms Inc <>:
BUZZ - Shares fall after US jury verdicts on social media harm nL6N40E0ZK

Liberty Energy Inc LBRT.N:
BUZZ - Edges up as convertible bond deal increased to $475 mln nL6N40E0XK

ImmunityBio Inc IBRX.O:
BUZZ - Says bladder cancer therapy on track for filing, shares rise nL4N40E15Z

Scotts Miracle-Gro Co SMG.N:
BUZZ - J.P. Morgan cuts Scotts Miracle-Gro rating over rising material costs nL6N40E0CJ

Fundrise Innovation Fund VCX.N:
BUZZ - Plunges after Citron Research discloses short position nL4N40E166

Adobe Inc ADBE.O:
BUZZ - Rises; William Blair assumes coverage with 'market perform' nL6N40E0QE

CNX Resources Corp CNX.N:

Energy Transfer LP ET.N:

Venture Global Inc VG.N:

NextDecade Corp NEXT.O:

BUZZ - US natgas stocks rise on bigger-than-expected storage draw nL4N40E1A1

Cirrus Logic Inc CRUS.O:
BUZZ - Soars to record on Apple partnership nL6N40E12C

Brown-Forman Corp BFb.N:
BUZZ - Jumps after report of merger talks with Pernod Ricard nL6N40E13Q

Salesforce Inc CRM.N:
BUZZ - Rises as US Department of Labor rolls out AI tool nL6N40E146

Stryker Corp SYK.N:
BUZZ - Rises after company says operations are recovering from cyberattack nL4N40E1FF