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Outlook Therapeutics slides after US FDA declines its eye disease drug
Outlook Therapeutics OTLK.O shares dive ~68% to $0.49 in extended trading after the U.S. Food and Drug Administration declined to approve its eye disease drugOTLK was testing drug Lytenava, for the treatment of wet age-related macular degeneration, a chronic eye disorder that causes blurred vision o...
Reuters
Wed, Dec 31
US FDA declines to approve Outlook's eye disease drug for second time in 2025
Dec 31 (Reuters) - Outlook Therapeutics OTLK.O said on Wednesday the U.S. health regulator has declined to approve its drug for a type of eye disease, dealing another blow in the company's prolonged push to bring the treatment to market and sending its shares tumbling nearly 70% after the bell.T...
Reuters
Wed, Dec 31
US stocks: Closing the books on a volatile 2025
Wall Street has closed the books on 2025, a year marked by large market swings, a tariff tantrum, both AI excitement and anxiety, more rate cuts, and spectacular gains in precious metalsS&P 500 index .SPX finished the month of Dec with a fractional loss, the fourth quarter with a 2.4% rise, and ...
Reuters
Wed, Dec 31
Berkshire falls on Buffett's last day as CEO, gained 6,100,000% over 60 years
By Jonathan Stempel Dec 31 (Reuters) - Berkshire Hathaway BRKa.N shares closed slightly lower on Warren Buffett's final day as chief executive, with the legendary investor set to hand the reins to Greg Abel on Thursday.The price of Berkshire Class A shares edged down $600, or 0.1%, to $754,80...
Reuters
Wed, Dec 31
Mexican main stock index jumps nearly 30% in 2025, best performance since 2009
MEXICO CITY, Dec 31 (Reuters) - Mexico's benchmark stock index .MXX rose 29.9% through 2025, data showed on Wednesday, the last day of the year, marking the index's best performance since 2009.
Reuters
Wed, Dec 31
US STOCKS-Wall Street ends year's final session lower but posts big annual gains for 2025
Indexes down: Dow 0.63%, S&P 500 0.74%, Nasdaq 0.76%All three indexes post yearly gainsNike up after CEO Hill buys stock worth $1 mlnVanda Pharma jumps after US FDA approves motion sickness drugBy Saeed Azhar, Purvi Agarwal and Nikhil Sharma NEW YORK, Dec 31 (Reuters) - Wall Street's majo...
Reuters
Wed, Dec 31
GLOBAL MARKETS-US stocks clinch double-digit annual gains, capping a stellar year
World stocks hover near all-time highs as curtain closes on banner yearPrecious metals pull back as investors cash in following huge gainsU.S. dollar suffers yearly loss, weighed by rate cuts, tariffsCrude prices see biggest annual drop since 2020By Stephen Culp NEW YORK, Dec 31 (Reuters) - Wall ...
Reuters
Wed, Dec 31
CANADA STOCKS-TSX records biggest annual gain in over 15 years despite year-end retreat
By Avinash PDec 31 (Reuters) - Canada's main stock index closed down on Wednesday, as falling metal prices pressured mining stocks and pulled the benchmark lower on the final trading day of a remarkable year for Canadian equities.The S&P/TSX Composite index .GSPTSE closed down 0.4% at 31,71...
Reuters
Wed, Dec 31
ANALYSIS-AI spending, strong corporate profits, Fed rate cuts seen as key to 2026 US stock market
S&P 500 posts 3rd straight year of gains over 10%Strong, broader US earnings growth expected in 2026AI momentum, Fed, US-China among potential swing factors By Lewis Krauskopf NEW YORK, Dec 31 (Reuters) - The U.S. stock market is closing the books on a third straight year of double-digit perc...
Reuters
Wed, Dec 31
LIVE MARKETS-A soft end to a strong year
Main US indexes end red; Nasdaq weakest, down ~0.75%All major S&P sectors lower; Real Estate weakest group, off ~1%Dollar ~flat; bitcoin, gold, crude declineUS 10-Year Treasury yield rises to ~4.16%Welcome to the home for real-time coverage of markets brought to you by Reuters reporters. You can...
Reuters
Wed, Dec 31
US STOCKS-Wall Street ends year's final session lower but ends 2025 with big annual gains
All three indexes see yearly gainsNike up after CEO Hill buys stock worth $1 mlnVanda Pharma jumps after US FDA approves motion sickness drugBy Saeed Azhar, Purvi Agarwal and Nikhil Sharma NEW YORK, Dec 31 (Reuters) - Wall Street's major indexes ended lower in the final trading session of 202...
Reuters
Wed, Dec 31
EMERGING MARKETS-LatAm FX caps a banner 2025, buoyed by yield hunt and diversification
Stocks up 46.4% in 2025, currencies gain 26.6%Chile, Colombia among best performersGeopolitics and election risks persist in 2026By Niket Nishant and Pranav Kashyap Dec 31 (Reuters) - Latin American currencies firmed in thin year-end trading on Wednesday, putting the finishing touches on a b...
Reuters
Wed, Dec 31
US STOCKS-Wall Street drops on tech, set to see annual gains
Indexes down: Dow 0.19%, S&P 500 0.15%, Nasdaq 0.12%All three indexes set for yearly gainsNike up after CEO Hill buys stock worth $1 mlnVanda Pharma jumps after US FDA approves motion sickness drugBy Purvi Agarwal, Nikhil Sharma and Saeed Azhar Dec 31 (Reuters) - Wall Street's major index...
Reuters
Wed, Dec 31
Florida-focused insurers set to end 2025 on high as momentum extends
Florida-focused insurers Heritage Insurance HRTG.N, Universal Insurance UVE.N, and HCI Group HCI.N set to end 2025 on a high noteLegislative reforms introduced in 2022 have significantly improved the property insurance landscape in Florida, a market where some large national insurers have scaled bac...
Reuters
Wed, Dec 31
Raymond James raises Freeport-McMoRan PT on copper outlook, improved Grasberg operations
Raymond James raises PT on copper miner Freeport-McMoRan FCX.N to $53 from $49, a 3% upside to stock's last closeBrokerage cites updated copper‑price assumptions, improved Grasberg certainty and stronger Indonesia productionEarly September, FCX had temporarily halted mining in Indonesia's Gr...
Reuters
Wed, Dec 31
U.S. STOCKS ON THE MOVE-Boeing, GlobalFoundries, Marriott
Eikon search string for individual stock moves: STXBZThe Day Ahead newsletter: https://refini.tv/3LI4BU7The Morning News Call newsletter: https://refini.tv/3dKUyB8Wall Street's major indexes inched lower in the final trading session of 2025, but approached a positive end to a roller-coaster year...
Reuters
Wed, Dec 31
Perfume sales thrive as U.S. beauty brands struggle with sluggish demand in 2025
U.S. beauty sector remained under pressure in 2025 due to tariff-led uncertainty, while focus on prestige brands and younger shoppers revived performance of cosmetics maker Estee Lauder EL.N and retailer Ulta Beauty ULTA.OCoty COTY.N, Elf Beauty ELF.N and Bath & Body Works BBWI.N logged the big...
Reuters
Wed, Dec 31
US FDA declines to approve Corcept's drug for rare hormonal disorder
By Sneha S K and Sahil PandeyDec 31 (Reuters) - The U.S. Food and Drug Administration has declined to approve Corcept Therapeutics' CORT.O drug for the treatment of a rare hormonal disorder, the company said on Wednesday.Shares of the drugmaker were down 48% at $36.41.The company said the FDA ...
Reuters
Wed, Dec 31
GLOBAL MARKETS-US stocks languid, precious metals retreat as markets turn the page on a stellar year
World stocks hover near all-time highs as banner year draws to a closePrecious metals pull back as investors cash in following huge gainsU.S. dollar set for yearly loss, weighed by rate cuts, tariffsAverage crude prices for the year lowest since 2020By Stephen Culp NEW YORK, Dec 31 (Reuters) - Wa...
Reuters
Wed, Dec 31
Will Nvidia Stock Boom in 2026?
Key PointsDespite phenomenal growth in 2025, Nvidia's stock is still relatively affordable compared to its growth and earnings. Investors should watch the spiraling cash burn situation with some of its major data center customers.10 stocks we like better than Nvidia › It's been roughly three years s...
The Motley Fool
Wed, Dec 31
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