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德琪医药(6996.HK)研发日:IO,ADC共舞,深度布局TCE

香港智远权证网2025年11月26日 00:00
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近日,德琪医药举办了研发日,首次全面披露其在ADC,TCE,IO及自免领域的深度布局.TCE作为其深度布局的领域,基于全新的2+1型AnTenGager平台,利用空间位阻,在降低CRS副作用的同时,提升疗效。

面向四大领域,德琪医药已经有多个管线深入布局,在ADC领域,靶向CLDN18.2的ATG-022一马当先,在临床中已经取得不错的疗效,后续还有靶向B7-H3/PD-L1的双抗ADC ATG-125和靶向CD24的ADC,后续两个药物是全新的IO+ADC的概念,和复宏汉霖的PD-L1-ADC相同的设计理念--IO及ADC双作用机制集于一身。在IO领域,口服小分子CD73抑制剂,实现对肿瘤微环境免疫抑制的逆转,并且在临床中也初现疗效。PD-L1/4-1BB双抗ATG-101可以实现对免疫系统的最大激动性,在设计理念上和维立志博类似。自免疾病领域,ATG-201通过靶向激活T细胞,从而对B细胞进行清除,进一步实现对B细胞相关自免疾病的治疗,而ATG-207同样是双靶向药物,可以实现对T细胞的耗竭,从而治疗T细胞引起的相关自免疾病。TCE作为德琪医药重点布局的领域,相关管线占据的其新药的半壁江山,从自免疾病,到血液瘤,再到实体瘤,覆盖了多种疾病(TCE平台后面详细介绍)

作为德琪医药的箭头产品,ATG-022靶向Claudin18.2,payload为微管抑制剂MMAE,linker为缬氨酸-瓜氨酸(VC),其在结合靶标后会被快速内吞,释放的payload同时具有较强的旁观者效应。临床前研究证明其在多种PDX模型中具有较强的抗肿瘤活性。

 

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