Cuộc họp công bố kết quả kinh doanh quý 3/2026 của Bioventus (BVS): Biên lợi nhuận mở rộng khi dự báo doanh thu giảm
Bioventus (NASDAQ: BVS) ghi nhận doanh thu quý 3 năm 2026 đạt 142 triệu USD, tăng 3% so với cùng kỳ. EBITDA điều chỉnh tăng gần 2 triệu USD lên 28 triệu USD, với biên lợi nhuận đạt 20%. EPS pha loãng điều chỉnh tăng 13% lên 0,17 USD.
Mảng Điều trị đau tăng 6% lên 71 triệu USD, trong khi doanh thu quốc tế tăng 16% lên 18 triệu USD. Tuy nhiên, công ty hạ dự báo doanh thu cả năm xuống 590 – 595 triệu USD do kết quả kém khả quan từ mảng vật liệu thay thế ghép xương. Dòng tiền kinh doanh đạt 21 triệu USD, giúp trả bớt nợ vay.
Bioventus (NASDAQ: BVS) báo cáo doanh thu quý 3 năm 2026 tăng trưởng 3%, nhờ doanh số bán hàng quốc tế và mảng Điều trị đau khởi sắc hơn bù đắp một phần cho sự sụt giảm ở mảng vật liệu thay thế ghép xương. Khả năng sinh lời được cải thiện bất chấp chi phí đầu tư cao hơn cho các sáng kiến tăng trưởng của công ty.
Điểm tin chính
- Doanh thu tăng 3% so với cùng kỳ năm ngoái lên 142 triệu USD, trong khi EBITDA điều chỉnh tăng gần 2 triệu USD lên 28 triệu USD.
- Biên EBITDA điều chỉnh tăng 70 điểm cơ bản lên 20%. EPS pha loãng điều chỉnh tăng 13% lên 0,17 USD.
- Doanh thu mảng Điều trị đau tăng 6% lên 71 triệu USD, nhờ sự đóng góp từ danh mục HA cùng đà tăng trưởng ban đầu của huyết tương giàu tiểu cầu (PRP) và kích thích thần kinh ngoại biên (PNS).
- Doanh thu quốc tế tăng 16%, tương đương 18% theo tỷ giá cố định, lên 18 triệu USD. Ban lãnh đạo dự kiến mức tăng trưởng hơn 20% trong quý 4.
- Bioventus đã hạ dự báo doanh thu cả năm xuống 590 triệu - 595 triệu USD, chủ yếu do kết quả hoạt động kém hơn kỳ vọng của mảng vật liệu thay thế ghép xương.
- Dòng tiền từ hoạt động kinh doanh đạt 21 triệu USD. Công ty đã trả thêm 19 triệu USD nợ vay, nâng tổng số tiền trả nợ vay có kỳ hạn từ đầu năm đến nay lên 65 triệu USD và đưa nợ ròng xuống dưới 200 triệu USD.
Kết quả tài chính cốt lõi
| Chỉ số | Quý 3/2026 | Thay đổi so với cùng kỳ | Ghi chú |
|---|---|---|---|
| Doanh thu | 142 triệu USD | +3% | Sự tăng trưởng của mảng Điều trị đau và các danh mục khác bù đắp một phần cho sự sụt giảm ở mảng BGS |
| Biên lợi nhuận gộp điều chỉnh | 75% | Giảm nhẹ | Cơ cấu sản phẩm là yếu tố chính |
| EBITDA điều chỉnh | 28 triệu USD | Tăng gần 2 triệu USD | Tăng trưởng nhanh hơn doanh thu |
| Biên EBITDA điều chỉnh | 20% | +70 điểm cơ bản | Cải thiện bất chấp đầu tư tăng trưởng gia tăng |
| EPS pha loãng điều chỉnh | 0,17 USD | +13% | Tăng từ 0,15 USD |
| Dòng tiền từ hoạt động kinh doanh | 21 triệu USD | — | Hỗ trợ trả thêm nợ vay |
| Tiền mặt | 31 triệu USD | — | Số dư cuối quý |
| Dư nợ | 230 triệu USD | — | Bao gồm khoản giảm 19 triệu USD trong quý |
Kết quả kinh doanh và hoạt động
Mảng Điều trị đau đạt doanh thu 71 triệu USD, tăng 6% so với cùng kỳ năm ngoái và tăng 9% tính từ đầu năm đến nay. Doanh thu từ bộ dụng cụ dùng một lần PRP đã vượt doanh thu bán thiết bị trong quý, điều mà ban lãnh đạo coi là chỉ báo quan trọng của nhu cầu định kỳ. Bioventus cũng đã giành được quyền độc quyền từ APEX Biologix để cung cấp giải pháp PRP cho các khách hàng trong lĩnh vực y học thể thao.
Việc triển khai PNS tiếp tục đạt tiến triển. Tỷ lệ chuyển đổi từ dùng thử sang cấy ghép vĩnh viễn vượt kế hoạch, khoảng thời gian giữa dùng thử và cấy ghép vĩnh viễn rút ngắn, và số lượng bác sĩ được đào tạo tăng hơn 50% so với quý trước. Ban lãnh đạo cho biết mảng kinh doanh này dự kiến sẽ mở rộng quy mô lên hơn 100 triệu USD trong những năm tới, dù chưa đưa ra dự báo cụ thể cho năm 2027.
Doanh thu mảng Giải pháp phẫu thuật tăng 1% lên 51 triệu USD. Mảng Thiết bị siêu âm đạt mức tăng trưởng hai chữ số mạnh mẽ, nhờ việc bán thiết bị, sự đón nhận của các bác sĩ phẫu thuật mới và sản lượng vật tư dùng một lần cao hơn. Ban lãnh đạo kỳ vọng đà tăng trưởng này sẽ tiếp tục trong quý 4 và hỗ trợ tăng tốc hơn nữa trong năm 2027.
Vật liệu thay thế ghép xương tiếp tục là yếu tố kìm hãm chính. Ban lãnh đạo cho biết sự sụt giảm này là do áp lực cạnh tranh ở các sản phẩm tổng hợp, số lượng ca phẫu thuật cột sống giảm bớt và sự chậm trễ tạm thời trong việc bổ sung nhà phân phối. Công ty đã triển khai các thay đổi vào cuối quý 3 và cho biết kết quả tháng 10 đang vượt kỳ vọng.
Doanh thu mảng Liệu pháp phục hồi giảm 3% xuống 21 triệu USD do vị trí tuyển dụng trống trong lực lượng bán hàng EXOGEN làm giảm sản lượng. Các vị trí đó hiện đã được lấp đầy. Ban lãnh đạo dự kiến mức tăng trưởng của EXOGEN sẽ cải thiện trong quý 4 và duy trì ở mức từ 1 chữ số thấp đến trung bình theo thời gian.
Doanh thu quốc tế tăng 16% lên 18 triệu USD, tương đương 18% theo tỷ giá cố định, nhờ tăng trưởng hai chữ số mạnh mẽ ở mảng Thiết bị siêu âm và HA. Ban lãnh đạo dự kiến doanh thu quốc tế sẽ tăng hơn 20% trong quý 4 và đạt mức tăng trưởng hai chữ số mạnh mẽ trong cả năm.
Dự báo của Ban lãnh đạo
| Chỉ số dự báo năm 2026 | Triển vọng cập nhật | Bình luận của ban lãnh đạo |
|---|---|---|
| Doanh thu | 590 triệu - 595 triệu USD | Hạ dự báo chủ yếu do mảng BGS; ngụ ý mức tăng trưởng quý 4 ở khoảng giữa một chữ số và tăng tốc so với quý trước |
| EPS pha loãng điều chỉnh | 0,75 - 0,79 USD | Tái khẳng định |
| Dòng tiền từ hoạt động kinh doanh điều chỉnh | 84 triệu - 89 triệu USD | Không bao gồm tác động đến dòng tiền từ việc đánh giá các lựa chọn chiến lược |
| Biên EBITDA điều chỉnh | Cao hơn mức năm ngoái | Được hỗ trợ nhờ kỷ luật vận hành và khả năng sinh lời của danh mục sản phẩm |
| Tỷ lệ đòn bẩy ròng | Dưới 1,5x vào cuối năm | Dự kiến sẽ giúp tiết kiệm thêm chi phí lãi vay |
Bioventus đã tăng khoản đầu tư dự kiến năm 2026 vào bốn động lực tăng trưởng—PNS, PRP, Thiết bị siêu âm và hoạt động quốc tế—từ 13 triệu USD lên gần 15 triệu USD. Hơn một nửa khoản đầu tư dành cho PNS. Ban lãnh đạo cho biết hoạt động đầu tư sẽ tiếp tục trong năm 2027, nhưng không ở mức tăng tương tự.
PRP và PNS hiện đang đóng góp thấp hơn một chút so với mục tiêu 200 điểm cơ bản về tăng trưởng bổ sung trước đó. Ban lãnh đạo cho biết kết quả quý 4 sẽ quyết định mức đóng góp cuối cùng cho cả năm.
Rủi ro và các điểm cần theo dõi
- Kết quả kinh doanh của BGS vẫn chịu ảnh hưởng bởi cạnh tranh trên thị trường sản phẩm tổng hợp, số lượng ca phẫu thuật cột sống suy giảm và tiến độ mở rộng nhà phân phối.
- Triển vọng doanh thu cả năm đã giảm khoảng 12 triệu USD ở điểm giữa của khoảng dự báo, trong đó hơn một nửa mức giảm liên quan đến kết quả quý 3 và chủ yếu ở mảng BGS.
- Sự phục hồi trong quý 4 của EXOGEN phụ thuộc một phần vào việc hòa nhập và năng suất của các vị trí bán hàng mới được tuyển dụng.
- Mảng Điều trị đau đối mặt với mức nền so sánh cao hơn trong quý 4 sau khi HA đạt mức tăng trưởng 14%–15% trong cùng kỳ năm trước.
- Việc đánh giá chiến lược do đề xuất thâu tóm tự tìm đến và nhiều sự quan tâm khác thúc đẩy vẫn đang tiếp diễn. Ban lãnh đạo không cung cấp mốc thời gian hay chi tiết bổ sung.
Điểm nhấn phiên Hỏi & Đáp với chuyên gia phân tích
Ban lãnh đạo cho biết sự sụt giảm ở mảng BGS tập trung chủ yếu vào các sản phẩm tổng hợp, mặc dù số lượng ca phẫu thuật giảm và tiến độ của nhà phân phối cũng ảnh hưởng đến danh mục rộng hơn. Các biện pháp được thực hiện vào cuối tháng 9 đã cho thấy kết quả tích cực trong tháng 10. Công ty vẫn tự tin vào chiến lược mạng lưới cung cấp tích hợp của mình và cho biết các khách hàng lớn đang ngày càng đánh giá từng sản phẩm dựa trên giá trị lâm sàng và kinh tế.
Đối với mảng Thiết bị siêu âm, ban lãnh đạo cho biết tăng trưởng phản ánh sự kết hợp giữa sự đón nhận của các bác sĩ phẫu thuật mới, việc tăng thêm điểm đặt thiết bị và mở rộng mức sử dụng vật tư dùng một lần so với quý trước. Tỷ lệ tiếp nhận của người dùng mới đang vượt tiến độ.
Về kiểm soát chi phí, ban lãnh đạo lưu ý rằng BGS có biên lợi nhuận biến đổi thấp hơn so với một số mảng kinh doanh khác. Do đó, việc hụt doanh thu ít ảnh hưởng đáng kể đến lợi nhuận hơn, trong khi chi phí hoa hồng và các chi phí biến đổi khác thấp hơn đã giúp tài trợ cho khoản đầu tư tăng thêm mà không làm cản trở sự mở rộng biên EBITDA.
Toàn văn Biên bản Cuộc họp Kết quả Kinh doanh
Toàn văn cuộc gọi công bố kết quả kinh doanh
Phần trình bày của ban lãnh đạo
Operator
Good afternoon, and welcome to the Bioventus Third Quarter 2026 Earnings Conference Call.
[Operator Instructions]
Please note, this event is being recorded.
I would now like to turn the conference over to Dave Crawford, Vice President, Investor Relations and Treasurer. Please go ahead.
David Crawford
Thanks, Drew, and good afternoon, everyone, and thanks for joining us. It is my pleasure to welcome you to the Bioventus 2026 third quarter earnings conference call. With me this afternoon are Rob Claypoole, President and CEO; and Mark Singleton, Senior Vice President and CFO. Rob will provide an update on our 2026 priorities and the third quarter highlights, and then Mark will review the third quarter results and discuss the update to our 2026 financial guidance. We will finish the call with Q&A. A presentation for today's call is available on the Investors section of our website, bioventus.com.
Before we begin, I would like to remind everyone that our remarks today contain forward-looking statements that are based on the current expectations of management and involve inherent risks and uncertainties that could cause actual results to differ materially from those indicated, including the risks and uncertainties described in the company's filings with the Securities and Exchange Commission, including Item 1A, Risk Factors, of the company's Form 10-K for the year ended December 31, 2025. Such factors may be updated from time to time in the company's other filings made with the Securities and Exchange Commission. You are cautioned not to place undue reliance upon any forward-looking statements, which speak only as of the date made.
Although the company may voluntarily do so from time to time, it undertakes no commitment to update or revise the forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by applicable securities laws. This call will also include references to certain financial measures that are not calculated in accordance with U.S. Generally Accepted Accounting Principles, or GAAP. We generally refer to these as non-GAAP or adjusted financial measures. Important disclosures about and definitions and reconciliations of those non-GAAP financial measures to the most comparable measures calculated and presented in accordance with GAAP are available in the earnings press release on the Investors section of our website, bioventus.com.
Now, I will turn the call over to Rob.
Robert Claypoole
Thank you, Dave. Good afternoon, everyone, and thanks for joining our call today. Bioventus continued to build on its positive momentum in the third quarter, delivering a solid financial performance and encouraging leading indicators across our growth drivers. These results reinforce our conviction and our ability to create sustainable long-term value for shareholders. Before going through the details on the third quarter, I will take a moment to provide a brief update on the strategic review we disclosed on our Q2 earnings call. With the assistance of our advisers, we continue to evaluate a range of strategic options for the company. As you may recall, this review was prompted by an unsolicited acquisition proposal and multiple expressions of interest. The process is ongoing, and we will continue to take the time necessary to fully assess all options and determine the best path forward for our shareholders.
We are not able to provide further details at this time and will not be answering any questions regarding the strategic review. Turning to the third quarter, I will update you on the three priorities we outlined at the start of the year. One, accelerating long-term revenue growth with increased investment in the four growth drivers: peripheral nerve stimulation, platelet-rich plasma, Ultrasonics, and our international business. Two, increasing earnings even with a higher level of investment in these four growth drivers. And three, continuing to strengthen cash flow and enhance capital allocation optionality. Let me expand on each priority, starting with accelerating long-term revenue growth. Overall, third quarter revenue grew 3%, led by strong growth of 6% in Pain Treatments. This performance was partially offset by softness in bone graft substitutes within Surgical Solutions, which continued to face near-term headwinds.
Excluding BGS, revenue growth for the rest of the business was 6% for the quarter, reflecting strong underlying momentum within each of the growth drivers. Let me highlight a few examples of the progress we are achieving with the growth drivers, starting with platelet-rich plasma, where momentum continues to build with sequential growth in the number of capital placements. Even more encouraging is the meaningful ramp-up in disposable reorders. During the third quarter, revenue from PRP disposable kits exceeded revenue from capital placements, which is an important indicator of future growth. We are pleased to see the growing adoption of our customizable solution and its potential to displace competitive offerings. In addition, we recently secured exclusive rights from our PRP partner, APEX Biologix, to offer our solution in sports medicine accounts.
This agreement broadens the addressable market and creates an additional avenue for growth as we continue to build commercial momentum. Next, our PNS business continues to gain traction, strengthening our confidence in both the market opportunity and the vast potential for our product offering. Physician feedback is very encouraging as clinicians gain more experience with TalisMann, providing further validation of our differentiated technology and launch strategy. Key performance indicators reinforce this progress. Trial to permanent conversion rates are exceeding plan, the time from trial to permanent implant placement has shortened, and the number of physicians trained grew by more than 50% quarter-over-quarter. Collectively, these trends point to growing physician engagement and improving conversion efficiency, key drivers for continued revenue growth acceleration.
We've also strengthened PNS leadership and commercial capabilities by hiring a best-in-class marketing leader, expanding our commercial infrastructure, equipping the team with more effective competitive selling and targeting tools, and increasing our presence at key medical congresses and industry meetings. Learnings in the initial launch phase, combined with these investments, position us to accelerate market adoption and capitalize on this significant growth opportunity. Turning to Ultrasonics, we saw very strong double-digit revenue growth this quarter. Investments in marketing and surgeon training are driving increased surgeon adoption, accelerated disposables growth, and new account wins. We expect this momentum to continue into the fourth quarter, paving the way for further growth acceleration in 2027. Finally, international revenue accelerated 16% in Q3, as we begin to see the impact from talent additions and the team's successful focus on select markets.
We are encouraged by the speed of execution, the depth of the opportunity pipeline, and our customer win rates. We expect to deliver strong double-digit growth in the fourth quarter and for the full year. Turning to our second priority, increasing earnings even as we invest in future growth drivers. The third quarter again demonstrated the underlying earnings power and resilience of Bioventus' business. Despite increased investment in growth initiatives, we delivered an adjusted EBITDA margin of 20%, an improvement of 70 basis points compared to the prior year period. Looking ahead, we now expect full-year adjusted EBITDA margin to be above the prior year level, reflecting our ability to balance strategic investment with operating discipline. With strong operating performance and significant interest expense savings, we delivered adjusted EPS of $0.17 in the quarter, which advanced 13% versus the prior year.
On a year-to-date basis, adjusted EPS has increased by 18%, underscoring our continued ability to grow earnings while investing in the opportunities that will drive long-term value for shareholders. As we close out the year, we expect to see sequential acceleration in revenue growth and earnings while continuing to increase our investments to drive growth and deliver on the full-year adjusted EPS guidance we provided at the beginning of the year. This reflects the strength of our business model, supported by the earnings power generated from solid revenue growth, our stable peer-leading gross margin, and the disciplined focus on operating expense management. Turning to our third priority, accelerated cash flow, we delivered another strong quarter with cash from operations of $21 million. This strong cash generation funded the repayment of an additional $19 million of our term loan, bringing year-to-date term loan repayments to $65 million.
This enabled us to achieve an important financial milestone of lowering net debt at the end of the quarter to below $200 million. Overall, we continue to execute on our strategic priorities, driving increased conviction in our strategy and growing confidence in the strength of the portfolio and investment approach as we build Bioventus into a leading $1 billion medtech company that delivers exceptional value for customers, employees, shareholders, and all other stakeholders.
Now I'll turn the call over to Mark to walk through the quarter results in more detail.
Mark Singleton
Thank you, Rob, and good afternoon, everyone. Let me start by saying I am excited about our ability to continue to increase profitability and deliver strong cash flow as we continue to invest in our future growth drivers. Turning to headline results for the third quarter, revenue of $142 million increased 3% compared to the prior year period. Growth was driven by strength in Pain Treatments, along with strong performance in other areas of the portfolio, which was partially offset by a slowdown in BGS within Surgical Solutions. Adjusted EBITDA of $28 million increased nearly $2 million compared to the prior year period and grew faster than revenue growth. Additionally, adjusted EBITDA margin of 20% expanded 70 basis points compared to the third quarter last year.
Adjusted earnings were $0.17 per diluted share for the quarter, up 13% compared to $0.15 in the prior year period. Now let me provide some additional commentary on the quarterly revenue. In global Pain Treatments, we delivered strong growth with revenue of $71 million, representing a 6% increase compared to the prior year. Pain Treatments is up 9% year-to-date, reflecting the strength of our broad HA portfolio, the differentiation of DUROLANE, and the strong early traction we are seeing with PRP and PNS. Moving to Surgical Solutions, revenue in Q3 totaled $51 million, which was an increase of 1% compared to the prior year. In Ultrasonics, we delivered strong double-digit growth with continued progress in capital placements and continued acceleration in disposable volume as we drive new surgeon adoption.
As Rob mentioned, the momentum with our strong underlying fundamentals support very strong growth for the fourth quarter and into 2027. As it relates to BGS, revenue came in lower than expected, as strong volume from new large IDN accounts was offset by modest softness in spine procedures, temporary delays in adding new distributors, and some competitive dynamics in the synthetic market. We implemented changes late in the third quarter and are seeing positive trends to start the fourth quarter. We continue to believe that these factors are transitory, and we continue to have strong conviction in our IDN strategy, the clinical and economic value proposition, and the long-term opportunity for this business. In Restorative Therapies, revenue of $21 million declined 3%. The quarter's results were driven by an impact to volume due to higher vacancies in the EXOGEN sales force that have since been filled.
Finally, international revenue of $18 million grew 16% compared to the prior year period, or 18% on a constant currency basis, primarily due to the strong double-digit growth in the Ultrasonics and HA businesses. Our growth outlook for international continues to be very strong, and we expect to generate more than 20% growth in the fourth quarter and continued excellent growth in 2027. Moving down the income statement, adjusted gross margin of 75% was slightly lower than the prior year period, primarily due to product mix. With respect to operating expenses, we remained disciplined with our spending while appropriately investing in our growth drivers and achieved adjusted EBITDA margin of 20% in the quarter. Turning to the balance sheet and cash flow statement, we continue to generate strong cash flow.
Cash flow from operations totaled $21 million during the quarter, and we ended the period with $31 million of cash on hand and $230 million of outstanding debt. During the quarter, we reduced debt by an additional $19 million, bringing the total debt repayment for the year to $65 million. We continue to expect our net leverage ratio to be below 1.5x by the end of this year. This stronger financial position is expected to drive further interest expense savings while enhancing our ability to strategically deploy capital towards the highest value opportunities. As a result of strong earnings and outlook for the business, we are reaffirming our full-year adjusted earnings per share guidance of $0.75 to $0.79 per diluted share.
We are adjusting our previously provided cash from operations guidance of $84 million to $89 million and presenting adjusted cash from operations in the same range, which excludes the cash flow impact of the company's review of potential strategic alternatives. With lower revenue expectations, primarily in BGS, we now expect 2026 revenue of $590 million to $595 million. This guidance reflects the expectations of mid-single-digit revenue growth in Q4 and sequential acceleration. In closing, we delivered a strong performance across key strategic segments of the business. The successful investments in our growth drivers, disciplined execution, enhanced profitability, and strong cash flow position us very well to increase our momentum and build a leading medtech company that creates meaningful long-term value for our shareholders.
Operator, please open the line for questions.
Operator
[Operator Instructions] The first question comes from Caitlin Roberts with Canaccord Genuity. Please go ahead.
Phần hỏi đáp
Caitlin Cronin
Maybe just to start on BGS, would love a little bit more color on the headwinds that you noted. And just with the spine market softness you called out, any concerns that, that could potentially impact Ultrasonics going forward?
Robert Claypoole
Yes, thanks, Caitlin. This is Rob. There were two primary drivers behind the Q3 BGS performance, both of which we view as transitory. First was we addressed some of the competitive dynamics in the synthetic market late in Q3 and already seeing positive results there with October tracking ahead. Second is that what you mentioned and what Mark Singleton mentioned, that slowdown in spine procedural volume and the number of new distributors we added, which are now ramping back up. I think really important to note there that we are already seeing positive results with October after the actions we took and ahead of our expectations. Just long term, very excited about our IDN strategy in this space, which is gaining significant momentum. As it relates to the procedures, it does not really impact from an Ultrasonics standpoint.
Keep in mind, we have relatively small business there, large market. We are changing the standard of care in that space, and so our strong volume was able to overcome anything that may have been happening from a procedural standpoint in that space.
Caitlin Cronin
Understood. Just turning to EXOGEN, expectations for the recovery here with the positions filled that you noted, and how much of that potential recovery is built into the revised revenue expectations?
Robert Claypoole
Yes. Well, for EXOGEN overall, we are making really good progress in refining commercial data analytics and targeting. We talked a little bit about that last time, and our messaging to help the team continue to get more efficient and effective in growing the business. Overall, this year, we expect the growth to be low single digits, which, for your comment, is towards the lower end of the range that we targeted for the year. That is factored into Q4 as well. But going forward, we expect this business to grow in the low single digit to mid-single digit range, consistent with what we have mentioned in the past.
Operator
The next question comes from Larry Solow with CJS Securities. Please go ahead.
Lawrence Solow
Could you maybe just give us a little more color, just on the granularity on the guidance, revised revenue guidance, like $12.5 million at the midpoint? Is that all BGS, or are we hitting that kind of 2% bar you set for PRP and PNS? I know you didn't give numbers there, but has anything else changed across the P&L in terms of the top line?
Robert Claypoole
Yes, Larry, this is Rob. I will start. We are lowering the full-year guidance by, as you mentioned, by approximately $12 million at the midpoint of the guidance range. Again, more than half of that is from Q3, and that was primarily driven by BGS, as mentioned. For Q4, the remainder of the reduction is due to BGS and the timing and contribution of new reps that we are onboarding. All that said, we expect a sequential acceleration in Q4 to mid-single-digit growth, and pleased to say that we are already seeing positive traction there with the first month of the quarter.
Lawrence Solow
Okay. On the BGS, the competitive dynamics, is that pricing, I am taking it? Was that kind of the, if you had to kind of bucket those three things, is there, they kind of split evenly, or is one heavier than the other? I mean, I know you have been walking away from some business, is that discretionarily? Is that continuing still, or on at least, at some point, I mean, in some respects?
Robert Claypoole
Yes. In the third quarter, really due to the two factors that we mentioned, the competitive dynamics in the synthetic space, again, already seeing positive results after taking the actions late in the quarter. Second, that slowdown in procedural volume with the number of new distributors that we added, which are now ramping back up. Those are the two primary causes for Q3, spread across the two of them. Again, just cannot emphasize enough that we are already seeing positive results in October. We do not usually talk about the current quarter in a call, but think it is important here to mention that seeing positive results with October ahead of our expectations. Longer term, again, just excited. We're gaining a lot of momentum with the IDN strategy that we've talked about before, already seeing some nice gains there, and expect that to contribute going forward.
Operator
The next question comes from Chase Knickerbocker with Craig-Hallum. Please go ahead.
Chase Knickerbocker
Sorry for another one on BGS here, but could you maybe just, with a little bit more detail, was the weakness isolated to SIGNAFUSE specifically? Maybe just talk about how OSTEOAMP performed in the quarter, kind of relative to SIGNAFUSE. Thanks.
Robert Claypoole
Yes, Chase. Primarily, we saw the impact in the quarter to the synthetic space. Again, that is because of some of the competitive dynamics, et cetera. When we mention the second reason of the slowdown in procedural volume and the number of new distributors added, obviously, that is across the portfolio, just not in the synthetic space. The good news, again, I will repeat a little bit here, but we took the actions at the end of September, and we are already seeing really positive traction there with October tracking ahead. I think that just underscores for us that we identified the right areas to focus on, took the actions early in the fourth quarter, but we are seeing an impact from the actions that we took.
Chase Knickerbocker
If we just think about kind of what the right expectations by segment are in Q4, you kind of talked about the changes to guidance, but maybe just a little bit more specifically on how quickly you think that could bounce back from those two, specifically to surgical, from those two specific headwinds. The second piece, we have heard from some competitors that seemingly some larger customers are more willing to separate out biologics RFPs. Can you just speak to what you are seeing from a customer perspective? Are you getting more kind of inbounds on participating in those RFP processes specifically for biologics?
Mark Singleton
Chase, this is Mark. I will start with just kind of going through the revenue when you look at it from the third quarter to fourth quarter sequentially. Overall, Restorative Therapies or EXOGEN, we would expect that growth rate to improve a little bit into 4Q. Again, we have the vacancies in 3Q. We have those filled, obviously have to get them on board, but from a growth perspective, we actually expect it to improve, even though that is part of the guidance reduction. From a pain perspective, great growth in 3Q as we talked about.
We look into Q4, we will see a slightly lower growth rate, not much, but really you have to remember, when we look into last year, our growth rate was 14% and 15% overall for HA, so it was a strong quarter in Pain Treatments last year that we are comparing to, but still feel really good about the growth drivers and about our HA business within Pain Treatments. From a surgical perspective, Ultrasonics again had a really strong quarter with double-digit growth. Obviously, we talked about the struggles that we have had with BGS, and we look into fourth quarter, as we talked about, BGS will be lower than our original expectations from a guidance perspective, but we do expect the growth to accelerate into fourth quarter.
That is kind of walking through that, and as Rob also pointed out, we are seeing some early signs of traction and improvement in fourth quarter in BGS. From a biologic RFPs, I am going to let Rob take that one.
Robert Claypoole
Yes. So Chase, on that, with the RFPs, the RFQs with the large accounts, particularly with the IDNs, they are putting out new requests for proposals with set formularies, and we are seeing that across the portfolio. What I think is most important there is that they are basing the decision-making on the clinical and economic value of each of the individual products. So, we like that they are getting their hands around it, and we like that they are basing it on that combination of clinical and economic value, and I think that is why we are seeing a lot of traction there, is because of our strong combination of clinical and economic value. So, really support what is happening there, and we are gaining traction and already seeing a nice contribution to our growth within that space from the activity with those large accounts.
Chase Knickerbocker
Got it. Maybe just last from me, it is a little bit tough for us sometimes to get a sense for kind of some of the specifics around PNS, just with it being in Pain Treatments. Can you maybe just give us a sense for your expectations for kind of growth contribution from PNS next year? Thank you.
Robert Claypoole
Yes, Chase. As it relates to specifics for 2027, I'm not going to obviously give any formal guidance or get too specific there, but I will give you some context on PNS. I mean, again, really excited about what we saw in Q3, which included the expansion of the team, new customers, new trials, which led to new implants, and just very positive feedback about both our trial device and the power of our permanent implant, TalisMann. As we alluded to, the leading indicators that we have are getting more and more defined, and they're tracking ahead of our launch plan, and we're just learning a lot about how to maximize our success with this business over the coming years. I'll tell you, that's what this year is all about.
We're investing in and activating our growth drivers while also very diligently analyzing our performance to shape the future decisions and investments to maximize our success. Hey, I fully expect the learnings, investments, revenue growth to keep ramping strongly, not just in Q4, but for your question, throughout 2027 and the future years. While I won't get specific on '27, we fully expect to scale this business to over $100 million in the coming years.
Operator
The next question comes from Mike Petusky with Barrington Research. Please go ahead.
Michael Petusky
I was wondering, the $13 million in incremental investment you guys sort of charted the course for at the beginning of the year, how far into that are you, and are you going to end up sort of investing that incremental $13 million, or is it going to come in less, or can you just speak to where you are on that? Thanks.
Robert Claypoole
Sure, Yes. Great question, Mike. We've accelerated our investments actually beyond the $13 million to almost $15 million, so a couple million more this year, and similar to what we've conveyed in the past, more than half of that's going to PNS, given the tremendous opportunity there and our build-out of the business. But really across all of them, we're investing in an exciting range of commercial activities and gathering a lot of data-backed insights on just how to best unlock the full potential of the growth drivers. I'd say in general, the fact that we're accelerating the investments beyond the $13 million to $15 million in the back half here just demonstrates how much we're learning and the insights we're gaining, and how confident we are in increasing our investment given in certain areas because of the positive traction that we're seeing.
And again, as it relates back to our earnings, it's nice to be able to drive up our investment like this and still deliver strong earnings for the quarter, and we expect to continue those investments going here through the fourth quarter, and not at the same rate in 2027, but of course, we'll be investing in those growth drivers in 2027 as well.
Michael Petusky
Sure. Appreciate all the data points you gave around PRP and PNS. Just curious, though, Rob, are you guys affirming sort of the 2% lift that you were expecting at the beginning of the year on those two, or are you essentially saying that there may be some timing that maybe 2% incremental associated with those two initiatives may not come in?
Robert Claypoole
Yes. As you alluded to there, really exciting traction with both. Currently tracking a little shy of the 200 basis points, but we will see what we can do in Q4. I would say either way, I couldn't be more excited about progress that we are making with both of them and the potential to enhance our overall growth profile, not just with those two, but all of our key growth drivers. We will let you know where we land after the year.
Michael Petusky
Okay. One more quick one, and then I will get off. In terms of the Ultrasonics momentum, is it primarily getting deeper in with docs in terms of just driving better utilization with sort of the guys you have relationships with, or are you really expanding the footprint of docs that are utilizing your Ultrasonics? Thanks.
Robert Claypoole
Yes, Mike. Really all of the above. The investments are working. They are having a clear impact. The team is doing an excellent job. Just to address a couple of points, we are ahead of schedule on new users or surgeon adoption, which is a really important leading indicator for us. We are also expanding our capital placements. Then, perhaps most importantly, we are seeing very positive continuous sequential growth trends in disposables. That is what really fueled the double-digit growth in Q3, is that combination. We look at this business, and we are in the early innings with activating the real potential of Ultrasonics, and just really looking forward to the path forward with this business.
Operator
We have a follow-up from Larry Solow with CJS Securities. Please go ahead.
Lawrence Solow
Great. I appreciate the extra time. Just on the I am curious, as Mike alluded to, you said the investments expense is actually spending up a couple million or up a couple million run rate. Where have you been able to cut the costs on that SG&A line, or at least keep SG&A relatively flat, I guess, year-over-year on an adjusted basis if we take out the you had a $3.5 million strategic alternatives expense that you took out there. On an adjusted basis, if it is keeping it flat on similar revenue year-over-year, it is continuing to invest, if you could just give us a little more color on where you have been able to take some costs out of the P&L.
Mark Singleton
Yes, Larry, this is Mark. Thanks for the question. First, we talked about our largest shortfall in revenue in 3Q and for guidance from a BGS perspective. That business is our lowest variable margin business compared to other businesses that have very lucrative variable margins. So, when we miss on that, the profit that we lose isn't as material as it would be in some of the other businesses. I also think this is a testament to the powerful P&L that we do have when we're driving above-market growth, and the gross margins that we have really gives us the control over P&L. We have the commissions come out for BGS, but then there's other levers that we have from a variable spending perspective that come out as well.
I think we've done a good job as a team over the last few years of really demonstrating the discipline and management of all of our costs. Most importantly, as Rob talked about in one of the earlier questions, amongst that, prioritizing our spending and still being able to make significant investments into the business that allows us to continue the momentum and the fuel that we're putting into these growth drivers of starting out the year of investing $13 million, it's up to $15 million. So really, overall, just the power of the P&L, the fact that we missed in our least lowest variable margin business is really the dynamics that's going on in the P&L, but it really just speaks to the strength of the powerful P&L that we do have.
Lawrence Solow
I appreciate that. That makes a lot of sense. If I could squeeze one more in. I know you don't want to answer any questions on this strategic process, but thoughts just from a rough timeline, approximate basis, would you like to optimally like to have something done by year end? Is that maybe a soft goal, soft target, if you will? Is there any, just any color on potential timing would be great if you can offer anything. Thanks.
Robert Claypoole
Yes, Larry. As noted in the prepared remarks, the strategic review remains ongoing, and really not able to comment further at this time about any of the details. So, thanks for that.
Lawrence Solow
I appreciate that. I figured I would try.
Operator
This concludes our question-and-answer session. I would like to turn the conference back over to Rob Claypoole for any closing remarks.
Robert Claypoole
Yes. Thanks, everyone. We delivered another strong quarter and are excited about the underlying momentum across our growth drivers. We're confident in our ability to deliver above-market revenue growth, increase earnings, and accelerate cash flow to create significant shareholder value.
Operator
The conference has now concluded. Thank you for attending today's presentation. You may now disconnect.
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