The current institutional shareholding score of Spero Therapeutics Inc is 3.00, ranking 192 out of 385 in the Biotechnology & Medical Research industry. The latest institutional shareholding proportion is 20.40%, representing a quarter-over-quarter increase of 23.43%. The largest institutional shareholder is James Simons, holding a total of 0.00 shares, representing 2.05% of shares outstanding, with 0.19% decrease in holdings.