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Upstream Bio Inc
UPBAdd to Watchlist
6.310USD
-0.260-3.96%
Close 07-31 16:00（ET）Quotes delayed by 15 min
343.39MMarket Cap
LossP/E TTM
Shareholding Stats
Updated: Thu, May 14
Updated: Thu, May 14
Shareholders
Shareholder Types
Shareholders
Shareholders
Proportion
Fidelity Management & Research Company LLC
13.36%
OrbiMed Advisors, LLC
10.46%
Access Industries, Inc.
10.10%
Decheng Capital LLC
5.78%
Norges Bank Investment Management (NBIM)
5.30%
Other
55.01%
Shareholders
Shareholders
Proportion
Fidelity Management & Research Company LLC
13.36%
OrbiMed Advisors, LLC
10.46%
Access Industries, Inc.
10.10%
Decheng Capital LLC
5.78%
Norges Bank Investment Management (NBIM)
5.30%
Other
55.01%
Shareholder Types
Shareholders
Proportion
Investment Advisor
43.95%
Investment Advisor/Hedge Fund
17.68%
Corporation
14.62%
Venture Capital
11.88%
Private Equity
10.46%
Hedge Fund
8.62%
Sovereign Wealth Fund
5.30%
Research Firm
0.96%
Bank and Trust
0.19%
Institutional Shareholding
Updated: Wed, Apr 1
Updated: Wed, Apr 1
Reporting Period
No. of institutions
Shares Held
Proportion
Change
2026Q1
235
56.28M
103.41%
+2.57M
2025Q4
184
50.20M
92.89%
+454.99K
2025Q3
146
50.98M
94.34%
+856.75K
2025Q2
141
56.33M
104.50%
+7.82M
2025Q1
136
58.61M
109.21%
+10.01M
2024Q4
100
57.72M
107.69%
+27.36M
Shareholder Activity
Name
Shares Held
Proportion
Change
Chg %
Date
Fidelity Management & Research Company LLC
7.27M
13.36%
-564.91K
-7.21%
Dec 31, 2025
OrbiMed Advisors, LLC
5.69M
10.46%
--
--
Dec 31, 2025
Access Industries, Inc.
5.49M
10.1%
+5.49M
--
Oct 15, 2024
Decheng Capital LLC
3.14M
5.78%
-142.22K
-4.33%
Dec 31, 2025
Norges Bank Investment Management (NBIM)
2.88M
5.3%
--
--
Dec 31, 2025
Enavate Sciences GP, LLC
2.46M
4.52%
--
--
Dec 31, 2025
BlackRock Institutional Trust Company, N.A.
2.30M
4.23%
+257.40K
+12.58%
Dec 31, 2025
HBM Partners AG
2.20M
4.03%
-519.95K
-19.15%
Sep 30, 2025
Janus Henderson Investors
1.53M
2.81%
+1.53M
--
Dec 31, 2025
View more
Related ETFs
Updated: Sat, Dec 6
Updated: Sat, Dec 6
Name
Proportion
Virtus LifeSci Biotech Clinical Trials ETF
1.51%
ALPS Medical Breakthroughs ETF
0.58%
State Street SPDR S&P Biotech ETF
0.27%
Fidelity Fundamental Small-Mid Cap ETF
0.24%
iShares Health Innovation Active ETF
0.18%
Direxion Daily S&P Biotech Bull 3X Shares
0.13%
Avantis US Small Cap Equity ETF
0.1%
Fidelity Enhanced Small Cap ETF
0.07%
iShares Russell 2000 Value ETF
0.06%
ProShares Hedge Replication ETF
0.04%
View more
Virtus LifeSci Biotech Clinical Trials ETF
Proportion1.51%
ALPS Medical Breakthroughs ETF
Proportion0.58%
State Street SPDR S&P Biotech ETF
Proportion0.27%
Fidelity Fundamental Small-Mid Cap ETF
Proportion0.24%
iShares Health Innovation Active ETF
Proportion0.18%
Direxion Daily S&P Biotech Bull 3X Shares
Proportion0.13%
Avantis US Small Cap Equity ETF
Proportion0.1%
Fidelity Enhanced Small Cap ETF
Proportion0.07%
iShares Russell 2000 Value ETF
Proportion0.06%
ProShares Hedge Replication ETF
Proportion0.04%